产品名称

英文名称：1-(2,3-Di(thiophen-2-yl)quinoxalin-6-yl)-3-(2-methoxyethyl)urea

同义词

Ac-CoA Synthase Inhibitor - CAS 508186-14-9 - Calbiochem, 1-(2,3-di(Thiophen-2-yl)quinoxalin-6-yl)-3-(2-methoxyethyl)urea, N-(2,3-di-2-Thienyl-6-quinoxalinyl)-Nʹ-(2-methoxyethyl)urea, Acyl-CoA Synthetase 2 short-chain Inhibitor; short-chain Acetyl-CoA Syn

产品性质

CAS编号：508186-14-9

分子式：C20H18N4O2S2

分子量：410.51

PubChem编号：2300455

英文别名：Ac-CoA Synthase Inhibitor - CAS 508186-14-9 - Calbiochem, 1-(2,3-di(Thiophen-2-yl)quinoxalin-6-yl)-3-(2-methoxyethyl)urea, N-(2,3-di-2-Thienyl-6-quinoxalinyl)-Nʹ-(2-methoxyethyl)urea, Acyl-CoA Synthetase 2 short-chain Inhibitor; short-chain Acetyl-CoA Syn

规格或纯度：98%

英文名称：1-(2,3-Di(thiophen-2-yl)quinoxalin-6-yl)-3-(2-methoxyethyl)urea

生化机理：Primary Target ACSS2 Reversible yes

储存温度：避光,-20°C储存

运输条件：超低温冰袋运输

产品介绍：ACSS2 inhibitor 是有效的、特异性的乙酰辅酶A合成酶2 (ACSS2)抑制剂。ACSS2 inhibitor 还可抑制呼吸道合胞体病毒(RSV)。A cell-permeable quinoxaline based compound that acts as a potent, reversible inhibitor of acetyl CoA synthetase (ACSS2; IC50 ~ 600 nM in a luciferase based assay). Exhibits selectivity over ACSF2 and ACSL5 acyl-CoA synthetases. Efficiently blocks the uptake of 14C tracer carbons from acetate into lipids (IC50 = 6.8 µM) and for histone acetylation (IC50 = 5.5 µM) in HepG2 cells. A cell-permeable quinoxaline based compound that acts as a potent, reversible inhibitor of acetyl CoA synthetase (ACSS2; IC50 ~ 600 nM in a luciferase based assay). Exhibits selectivity over ACSF2 and ACSL5 acyl-CoA synthetases. Efficiently blocks the uptake of 14C tracer carbons from acetate into lipids (IC50 = 6.8 µM) and for histone acetylation (IC50 = 5.5 µM) in HepG2 cells. Please note that the molecular weight for this compound is batch-specific due to variable water content. Please refer to the vial label or the certificate of analysis for the batch-specific molecular weight. The molecular weight provided represents the baseline molecular weight without water.

IUPAC Name：1-(2,3-dithiophen-2-ylquinoxalin-6-yl)-3-(2-methoxyethyl)urea

INCHI：InChI=1S/C20H18N4O2S2/c1-26-9-8-21-20(25)22-13-6-7-14-15(12-13)24-19(17-5-3-11-28-17)18(23-14)16-4-2-10-27-16/h2-7,10-12H,8-9H2,1H3,(H2,21,22,25)

InChi Key：CTPVNWVUAGMHEJ-UHFFFAOYSA-N

Canonical SMILES：COCCNC(=O)NC1=CC2=C(C=C1)N=C(C(=N2)C3=CC=CS3)C4=CC=CS4

Isomeric SMILES：COCCNC(=O)NC1=CC2=C(C=C1)N=C(C(=N2)C3=CC=CS3)C4=CC=CS4

PubChem CID：2300455

敏感性：对光线敏感

产品包装