产品名称

英文名称：Loratadine

同义词

loratadine、79794-75-5、Claritin、Alavert、Loratidine、Clarityn、Lisino、Clarityne、Loracert、Loradex、Bonalerg、Claritine、Fristamin、Histaloran、Lertamine、Lorastine、Loratyne、Civeran、Loranox、Versal、Aerotina、Alerpriv、Allertidin、Anhissen、Claratyne、Lorantis、Loritine、Lowa、克敏能、氯雷他定、4-(8-氯-5,6-二氢-11H-苯并[5,6]环庚基[1,2-b]并吡啶-11-烯)-1-哌啶羧酸乙脂、4-(8-氯-5,6-二氢-11H-苯并[5,6]环庚[1,2-b]吡啶-11-亚基-1-哌啶羧酸乙酯

产品性质

CAS编号：79794-75-5

分子式：C22H23ClN2O2

分子量：382.88

MDL号：MFCD00672869

PubChem编号：3957

别名：克敏能|氯雷他定|4-(8-氯-5,6-二氢-11H-苯并[5,6]环庚基[1,2-b]并吡啶-11-烯)-1-哌啶羧酸乙脂|4-(8-氯-5,6-二氢-11H-苯并[5,6]环庚[1,2-b]吡啶-11-亚基-1-哌啶羧酸乙酯

英文别名：loratadine|79794-75-5|Claritin|Alavert|Loratidine|Clarityn|Lisino|Clarityne|Loracert|Loradex|Bonalerg|Claritine|Fristamin|Histaloran|Lertamine|Lorastine|Loratyne|Civeran|Loranox|Versal|Aerotina|Alerpriv|Allertidin|Anhissen|Claratyne|Lorantis|Loritine|Lowa

规格或纯度：≥98%

英文名称：Loratadine

生化机理：Loratadine is a non-sedative antihistamine that inhibits histamine-induced activities of IL-6 and IL-8 secretion in endothelial cells. Loratadine is a selective inverse peripheral histamine H1-receptor agonist (IC50 > 32 μM).H 1 receptor antagonist (K i values are 16 nM for H 1 and 2-10 μM for M 1-5 receptors). Antiallergenic activities.

储存温度：2-8°C储存

运输条件：冰袋运输

备注：500mg卖完停产，不再备货，如果有可能，您尽量在使用的当天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，它们最多可以使用一个月。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。

产品介绍：Loratadine是一种选择性的，逆向外周组胺H1受体激动剂，IC50大于32 μM。A peripheral histamine H1 receptor agonist.Loratadine is a selective inverse peripheral histamine H1-receptor agonist with an IC50 of >32 μM.A peripheral histamine H1 receptor agonist.

ALogP：5.2

IUPAC Name：ethyl 4-(13-chloro-4-azatricyclo[9.4.0.03,8]pentadeca-1(11),3(8),4,6,12,14-hexaen-2-ylidene)piperidine-1-carboxylate

INCHI：InChI=1S/C22H23ClN2O2/c1-2-27-22(26)25-12-9-15(10-13-25)20-19-8-7-18(23)14-17(19)6-5-16-4-3-11-24-21(16)20/h3-4,7-8,11,14H,2,5-6,9-10,12-13H2,1H3

InChi Key：JCCNYMKQOSZNPW-UHFFFAOYSA-N

Canonical SMILES：CCOC(=O)N1CCC(=C2C3=C(CCC4=C2N=CC=C4)C=C(C=C3)Cl)CC1

Isomeric SMILES：CCOC(=O)N1CCC(=C2C3=C(CCC4=C2N=CC=C4)C=C(C=C3)Cl)CC1

WGK Germany：2

RTECS：TM6129200

PubChem CID：3957

Reaxy-Rn：4273483

溶解性：Soluble in DMSO (50 mg/ml), ethanol (77 mg/ml at 25 °C), water (<1 mg/ml at 25 °C), chloroform, and methanol.

熔点：137°C

象形图：

信号词：Danger

危险声明：H315 Causes skin irritationH319 Causes serious eye irritationH335 May cause respiratory irritationH351 Suspected of causing cancerH400 Very toxic to aquatic lifeH410 Very toxic to aquatic life with long lasting effectsH360 May damage fertility or the unborn childH361 Suspected of damaging fertility or the unborn childH362 May cause harm to breast-fed children

预防措施声明：P261,P305+P351+P338,P273,P280,P302+P352,P321,P405,P501,P264,P260,P271,P270,P304+P340,P403+P233,P362+P364,P391,P263,P203,P264+P265,P318,P337+P317,P332+P317,P319

Merck Index：5578

个人防护装备：Eyeshields， Gloves， type N95 (US)， type P1 (EN143) respirator filter

产品包装