产品名称

英文名称：Imperatorin

同义词

IMPERATORIN、482-44-0、Ammidin、Marmelosin、Pentosalen、8-Isoamylenoxypsoralen、8-Isopentenyloxypsoralene、Marmelide、NSC 402949、9-(3-methylbut-2-enoxy)furo[3,2-g]chromen-7-one、CCRIS 4346、HSDB 3497、9-(3-Methylbut-2-enyloxy)furo(3,2-g)chromen-7-one、EINECS 207-581-、前胡内酯、白芷乙素、前胡素、8-(3-甲基-2-丁烯氧基)补骨脂素、8-异戊烯氧基补骨脂素、白茅苷、9-[(3-甲基-2-丁烯-1-基)氧]-7H-呋喃并[3,2-g]色满-7-酮

产品性质

CAS编号：482-44-0

分子式：C16H14O4

分子量：270.28

EC号：207-581-1

MDL号：MFCD00016881

PubChem编号：10212

别名：前胡内酯|白芷乙素|前胡素|8-(3-甲基-2-丁烯氧基)补骨脂素|8-异戊烯氧基补骨脂素|白茅苷|9-[(3-甲基-2-丁烯-1-基)氧]-7H-呋喃并[3,2-g]色满-7-酮

英文别名：IMPERATORIN|482-44-0|Ammidin|Marmelosin|Pentosalen|8-Isoamylenoxypsoralen|8-Isopentenyloxypsoralene|Marmelide|NSC 402949|9-(3-methylbut-2-enoxy)furo[3,2-g]chromen-7-one|CCRIS 4346|HSDB 3497|9-(3-Methylbut-2-enyloxy)furo(3,2-g)chromen-7-one|EINECS 207-581-

规格或纯度：≥98% (HPLC)

英文名称：Imperatorin

生化机理：欧前胡素是p38、ERK路径的调控因子。欧前胡素增加BMP-2的表达(mRNA) ,体外研究证实欧前胡素增加体内骨质密度/体积和矿物化。细胞周期蛋白D1抑制剂。诱导细胞周期停滞在G1。激活胱天蛋白酶9并诱导凋亡。抑制HIV-1复制。TRPV1激动剂弱（EC 50 = 13μM）。显示出抗增殖作用。在体内显示镇痛作用。

储存温度：-20°C储存

运输条件：超低温冰袋运输

备注：10mg卖完停产，不再备货；如果有可能，您尽量在使用的当天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，它们最多可以使用一个月。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。

产品介绍：属呋喃香豆素类化合物。为棱柱状结晶（由乙醚）、长细针晶（由热水），易溶于氯仿，可溶于苯、乙醇、乙醚和苛性碱溶液，不溶于冷水。 Imperatorin is a furocoumarin present in citrus fruits, which is used in HIV-1 research. Studies indicate that the transcription factor Sp1 is essential in the inhibitory functions of Imperatorin. In addition, Imperatorin inhibits cyclin D1 expression and stops the cell cycle at G1. These studies also sμggest that Imperatorin suppresses HIV-1 replication in primary T lymphocytes and transformed cell lines. Furthermore, it has been sμggested that the inhibitory effects of Imperatorin on HIV-1 at the transcriptional level can be monitored effectively in HeLa cells. Imperatorin can also cause apoptosis in human promyelocytic leukaemia, HL-60 via the cytochrome c/caspase-9 pathway.Imperatorin is a furocoumarin present in citrus fruits, which is used in HIV-1 research. Studies indicate that the transcription factor Sp1 is essential in the inhibitory functions of Imperatorin. In addition, Imperatorin inhibits cyclin D1 expression and stops the cell cycle at G1. These studies also suggest that Imperatorin suppresses HIV-1 replication in primary T lymphocytes and transformed cell lines. Furthermore, it has been suggested that the inhibitory effects of Imperatorin on HIV-1 at the transcriptional level can be monitored effectively in HeLa cells. Imperatorin can also cause apoptosis in human promyelocytic leukaemia, HL-60 via the cytochrome c/caspase-9 pathway.

IUPAC Name：9-(3-methylbut-2-enoxy)furo[3,2-g]chromen-7-one

INCHI：InChI=1S/C16H14O4/c1-10(2)5-7-19-16-14-12(6-8-18-14)9-11-3-4-13(17)20-15(11)16/h3-6,8-9H,7H2,1-2H3

InChi Key：OLOOJGVNMBJLLR-UHFFFAOYSA-N

Canonical SMILES：CC(=CCOC1=C2C(=CC3=C1OC=C3)C=CC(=O)O2)C

Isomeric SMILES：CC(=CCOC1=C2C(=CC3=C1OC=C3)C=CC(=O)O2)C

WGK Germany：3

PubChem CID：10212

溶解性：Soluble in DMSO (≥5 mg/ml), methanol, DMF, and water (slightly). Insoluble in ethanol.

密度：1.242

敏感性：对热敏感

熔点：97.0 to 101.0 °C

象形图：

信号词：Warning

危险声明：H315 Causes skin irritationH319 Causes serious eye irritationH335 May cause respiratory irritationH302 Harmful if swallowedH317 May cause an allergic skin reaction

预防措施声明：P261,P305+P351+P338,P280,P302+P352,P321,P405,P501,P264,P271,P270,P304+P340,P403+P233,P272,P333+P313,P362+P364,P330,P264+P265,P301+P317,P337+P317,P332+P317,P319

Merck Index：4925

个人防护装备：Eyeshields,Gloves,type N95 (US),type P1 (EN143) respirator filter

产品包装