产品名称

英文名称：Gimeracil

同义词

Gimeracil、103766-25-2、gimestat、5-Chloro-2,4-dihydroxypyridine、5-chloropyridine-2,4-diol、5-Chloro-4-hydroxy-2(1H)-pyridone、5-Chloro-4-hydroxy-2(1H)-pyridinone、Gimeracil [INN]、5-Chloro-4-hydroxy-1H-pyridin-2-one、5-Chloro-2,4-pyridinediol、5-CHLORO-4-HYDROXYP、吉美拉西、吉美嘧啶、吉莫斯特、5-氯-2,4-二羟基吡啶、5-氯-2,4-吡啶醇、5-氯-4-羟基-2(1H)-吡啶酮

产品性质

CAS编号：103766-25-2

分子式：C5H4ClNO2

分子量：145.54

Beilstein号：21(4)2059

MDL号：MFCD08458352

PubChem编号：54679224

别名：吉美拉西|吉美嘧啶|吉莫斯特|5-氯-2,4-二羟基吡啶|5-氯-2,4-吡啶醇|5-氯-4-羟基-2(1H)-吡啶酮

英文别名：Gimeracil|103766-25-2|gimestat|5-Chloro-2,4-dihydroxypyridine|5-chloropyridine-2,4-diol|5-Chloro-4-hydroxy-2(1H)-pyridone|5-Chloro-4-hydroxy-2(1H)-pyridinone|Gimeracil [INN]|5-Chloro-4-hydroxy-1H-pyridin-2-one|5-Chloro-2,4-pyridinediol|5-CHLORO-4-HYDROXYP

规格或纯度：≥98%

英文名称：Gimeracil

生化机理：Gimeracil is an antitumor agent and a potent inhibitor of dihydropyrimidine dehydrogenase (DPD).

储存温度：-20°C储存

运输条件：超低温冰袋运输

备注：250mg售完停产，不再备货

产品介绍：Gimeracil是一种二氢脱氢酶的抑制剂，在双链断裂修复中，抑制早期同源重组。A potent inhibitor of dihydropyrimidine dehydrogenase (DPD).Gimeracil is an inhibitor of dihydropyrimidine dehydrogenase, which inhibits the early step in homologous recombination for double strand breaks repair.A potent inhibitor of dihydropyrimidine dehydrogenase (DPD).

ALogP：-0.1

IUPAC Name：5-chloro-4-hydroxy-1H-pyridin-2-one

INCHI：InChI=1S/C5H4ClNO2/c6-3-2-7-5(9)1-4(3)8/h1-2H,(H2,7,8,9)

InChi Key：ZPLQIPFOCGIIHV-UHFFFAOYSA-N

Canonical SMILES：C1=C(C(=CNC1=O)Cl)O

Isomeric SMILES：C1=C(C(=CNC1=O)Cl)O

PubChem CID：54679224

Reaxy-Rn：119489

溶解性：Soluble in DMSO (29 mg/ml at 25 °C), water (<1 mg/ml at 25 °C), and ethanol (<1 mg/ml at 25 °C).

熔点：274°C(dec.)(lit.)

象形图：

信号词：Warning

危险声明：H315 Causes skin irritationH319 Causes serious eye irritationH335 May cause respiratory irritationH302 Harmful if swallowed

预防措施声明：P261,P305+P351+P338,P280,P302+P352,P321,P405,P501,P264,P271,P270,P304+P340,P403+P233,P362+P364,P330,P264+P265,P301+P317,P337+P317,P332+P317,P319

产品包装