产品名称

英文名称：Amoxapine

同义词

amoxapine、14028-44-5、Asendin、Demolox、Moxadil、Amoxan、Desmethylloxapin、Amoxapinum、Amoxapina、Amoxepine、CL-67772、CL 67772、Dibenz[b,f][1,4]oxazepine, 2-chloro-11-(1-piperazinyl)-、2-Chloro-11-(1-piperazinyl)dibenz(b,f)(1,4)oxazepine、Amoxapinum [INN-Latin]、Amoxa、阿莫沙平、2-氯-11-(1-哌嗪基)二苯并[b,f][1,4]氧氮杂卓、氯氧平、氯哌氧卓、哔氯苯氧氮卓、氯哌氧

产品性质

CAS编号：14028-44-5

分子式：C17H16ClN3O

分子量：313.78

EC号：237-867-1

MDL号：MFCD00069210

PubChem编号：2170

别名：阿莫沙平|2-氯-11-(1-哌嗪基)二苯并[b,f][1,4]氧氮杂卓|氯氧平|氯哌氧卓|哔氯苯氧氮卓|氯哌氧

英文别名：amoxapine|14028-44-5|Asendin|Demolox|Moxadil|Amoxan|Desmethylloxapin|Amoxapinum|Amoxapina|Amoxepine|CL-67772|CL 67772|Dibenz[b,f][1,4]oxazepine, 2-chloro-11-(1-piperazinyl)-|2-Chloro-11-(1-piperazinyl)dibenz(b,f)(1,4)oxazepine|Amoxapinum [INN-Latin]|Amoxa

规格或纯度：≥98%

英文名称：Amoxapine

生化机理：inhibits uptake of norepinephrine; inhibits 5-HT2 serotonergic receptors.Norepinephrine and serotonin reuptake inhibitor. D 2 and 5-HT 2 receptor antagonist. Inhibits rectifier outward K+ currents via a cAMP/PKA-dependent pathway (IC 50 = 211.36 μM). Antipsychotic and antidepressant effects in vivo. Orally active.

应用：A strong norepinephrine reuptake inhibitor and weak serotonin reuptake inhibitor

储存温度：-20°C储存

运输条件：超低温冰袋运输

备注：如果有可能，您尽量在使用的当天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，它们最多可以使用一个月。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。

产品介绍：Amoxapine is a tricyclic antidepressant known to inhibit reuptake of neuronal transmitter. The drug helps in controlling agitation and anxiety along with depression.Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.ApplicationAmoxapine may be used as a pharmaceutical reference standard for the determination of the analyte in drug dosage forms by ultraviolet-spectrophotometric method.These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

ALogP：2.6

PubChem SID：488179670

PubChem SID url：https//pubchem.ncbi.nlm.nih.gov/substance/488179670

IUPAC Name：8-chloro-6-piperazin-1-ylbenzo[b][1,4]benzoxazepine

INCHI：InChI=1S/C17H16ClN3O/c18-12-5-6-15-13(11-12)17(21-9-7-19-8-10-21)20-14-3-1-2-4-16(14)22-15/h1-6,11,19H,7-10H2

InChi Key：QWGDMFLQWFTERH-UHFFFAOYSA-N

Canonical SMILES：C1CN(CCN1)C2=NC3=CC=CC=C3OC4=C2C=C(C=C4)Cl

Isomeric SMILES：C1CN(CCN1)C2=NC3=CC=CC=C3OC4=C2C=C(C=C4)Cl

WGK Germany：3

RTECS：HQ4025500

PubChem CID：2170

DrugBank Ligand：DB00543

CAS Registry No.：14028-44-5

ChEBI：CHEBI2675

Wikipedia：Amoxapine

ChEMBL Ligand：CHEMBL1113

BindingDB Ligand：22870

PEP：amoxapine

DrugCentral Ligand：191

GPCRdb Ligand：amoxapine

溶解性：DMSO 0.1 mg/mL Water <1 mg/mL Ethanol <1 mg/mL

熔点：178.0-182.0 °C

象形图：

信号词：Warning

危险声明：H302 Harmful if swallowed

预防措施声明：P501,P264,P270,P330,P301+P317

Merck Index：576

个人防护装备：dust mask type N95 (US), Eyeshields, Faceshields, Gloves

产品包装