产品名称

英文名称：5-Hydroxy-1,4-naphthoquinone

同义词

juglone、481-39-0、5-Hydroxy-1,4-naphthoquinone、5-Hydroxy-1,4-naphthalenedione、5-Hydroxynaphthalene-1,4-dione、Regianin、Nucin、Juglon、Akhnot、Yuglon、C.I. Natural Brown 7、8-Hydroxy-1,4-naphthoquinone、5-Hydroxynaphthoquinone、1,4-NAPHTHALENEDIONE, 5-HYDROXY-、5-Hy、胡桃醌、胡桃酮

产品性质

CAS编号：481-39-0

分子式：C10H6O3

分子量：174.16

Beilstein号：8308

MDL号：MFCD00001684

PubChem编号：3806

别名：胡桃醌|胡桃酮

英文别名：juglone|481-39-0|5-Hydroxy-1,4-naphthoquinone|5-Hydroxy-1,4-naphthalenedione|5-Hydroxynaphthalene-1,4-dione|Regianin|Nucin|Juglon|Akhnot|Yuglon|C.I. Natural Brown 7|8-Hydroxy-1,4-naphthoquinone|5-Hydroxynaphthoquinone|1,4-NAPHTHALENEDIONE, 5-HYDROXY-|5-Hy

规格或纯度：≥97.0%(GC)

英文名称：5-Hydroxy-1,4-naphthoquinone

生化机理：Jμglone inhibits the transcription of Pol II (RNA polymerase II) by changing the sulfhydryl groups and blocking the assembly of the preinitiation complex. Other studies show that Jμglone does not block T7 RNA polymerase but that it inhibits Pol II and Pol III (RNA polymerase II and III). Human Pin1, Escherichia coli parvulin, and the yeast Ess1/Ptf1 have been shown to be blocked specifically and irreversibly by Jμglone. Additionally, Jμglone is an antifibrotic compound and promotes apoptosis via the mitochondrial-dependent pathway. Jμglone is an inhibitor of Cyclophilin and Pin4.

储存温度：2-8°C储存

运输条件：冰袋运输

产品介绍：A compound that inhibits RNA polymerasesA compound that inhibits RNA polymerases

IUPAC Name：5-hydroxynaphthalene-1,4-dione

INCHI：InChI=1S/C10H6O3/c11-7-4-5-9(13)10-6(7)2-1-3-8(10)12/h1-5,12H

InChi Key：KQPYUDDGWXQXHS-UHFFFAOYSA-N

Canonical SMILES：C1=CC2=C(C(=O)C=CC2=O)C(=C1)O

Isomeric SMILES：C1=CC2=C(C(=O)C=CC2=O)C(=C1)O

WGK Germany：3

RTECS：QJ5775000

PubChem CID：3806

UN Number：2811

Packing Group：III

Reaxy-Rn：1909764

溶解性：Soluble in DMSO (10 mg/ml), ethanol (10 mg/ml), benzene (Freely soluble), chloroform (Freely soluble), ether, aqueous solution of alkalies, and hot water.

敏感性：对光线敏感

闪点(℃)：201.3ºC

沸点：385.8ºC at 760 mmHg

熔点：155°C(lit.)

象形图：

信号词：Danger

危险声明：H315 Causes skin irritationH319 Causes serious eye irritationH335 May cause respiratory irritationH301 Toxic if swallowedH400 Very toxic to aquatic life

预防措施声明：P261,P305+P351+P338,P273,P280,P302+P352,P321,P405,P501,P264,P271,P270,P304+P340,P403+P233,P362+P364,P391,P330,P264+P265,P301+P316,P337+P317,P332+P317,P319

Class：6.1

Merck Index：5269

个人防护装备：Eyeshields， Faceshields， Gloves， type P2 (EN 143) respirator cartridges

产品包装