产品名称

英文名称：Puromycin aminonucleoside

同义词

Puromycin aminonucleoside、58-60-6、Stylomycin aminonucleoside、3'-amino-3'-deoxy-n6,n6-dimethyladenosine、Aminonucleoside、3'-Amino-3'-deoxy-N,N-dimethyladenosine、6-Dimethylamino-9-(3'-ribosylamine)purine、ADENOSINE, 3'-AMINO-3'-DEOXY-N,N-DIMETHYL-、PANS、CHEBI

产品性质

CAS编号：58-60-6

分子式：C12H18N6O3

分子量：294.31

Beilstein号：93902

EC号：200-388-3

MDL号：MFCD00063462

PubChem编号：6020

英文别名：Puromycin aminonucleoside|58-60-6|Stylomycin aminonucleoside|3'-amino-3'-deoxy-n6,n6-dimethyladenosine|Aminonucleoside|3'-Amino-3'-deoxy-N,N-dimethyladenosine|6-Dimethylamino-9-(3'-ribosylamine)purine|ADENOSINE, 3'-AMINO-3'-DEOXY-N,N-DIMETHYL-|PANS|CHEBI

规格或纯度：98%

英文名称：Puromycin aminonucleoside

生化机理：Puromycin aminonucleoside is used to study human glomerular disease by inducing damage of murine glomerular podocytes1 and is used to study glomerular function and morphology.Podocyte toxin, induces ROS and oxidant-dependent DNA damage in podocytes. Puromycin analogue that does not inhibit protein synthesis or induce DNA fragmentation. Antibiotic, antineoplastic and antimetabolite agent. Active in vivo and in vitro .

应用：The aminonucleoside portion of the antibiotic puromycin.

储存温度：避光,-20°C储存

运输条件：超低温冰袋运输

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产品介绍：Puromycin Aminonucleoside (3'-Amino-3'-deoxy-N6,N6-dimethyladenosine) is the aminonucleoside portion of the antibiotic puromycin. It is a puromycin analog which does not inhibit protein synthesis or induce apoptosis. Used in the study of focal and segmental glomerulosclerosis and in the induction of nephrosis in rats. The excretion of sodium and NOx metabolites in rats with puromycin aminonucleoside-induced nephrotic syndrome has been studied. Used to probe endothelial glycosaminoglycan synthesis in cultured glomerular endothelial cells and their relation to cell permeabilityThe aminonucleoside portion of the antibiotic puromycin.Puromycin Aminonucleoside (3'-Amino-3'-deoxy-N6,N6-dimethyladenosine) is the aminonucleoside portion of the antibiotic puromycin. It is a puromycin analog which does not inhibit protein synthesis or induce apoptosis. Used in the study of focal and segmental glomerulosclerosis and in the induction of nephrosis in rats. The excretion of sodium and NOx metabolites in rats with puromycin aminonucleoside-induced nephrotic syndrome has been studied. Used to probe endothelial glycosaminoglycan synthesis in cultured glomerular endothelial cells and their relation to cell permeabilityThe aminonucleoside portion of the antibiotic puromycin.

IUPAC Name：(2R,3R,4S,5S)-4-amino-2-[6-(dimethylamino)purin-9-yl]-5-(hydroxymethyl)oxolan-3-ol

INCHI：InChI=1S/C12H18N6O3/c1-17(2)10-8-11(15-4-14-10)18(5-16-8)12-9(20)7(13)6(3-19)21-12/h4-7,9,12,19-20H,3,13H2,1-2H3/t6-,7-,9-,12-/m1/s1

InChi Key：RYSMHWILUNYBFW-GRIPGOBMSA-N

Canonical SMILES：CN(C)C1=NC=NC2=C1N=CN2C3C(C(C(O3)CO)N)O

Isomeric SMILES：CN(C)C1=NC=NC2=C1N=CN2[C@H]3[C@@H]([C@@H]([C@H](O3)CO)N)O

WGK Germany：3

PubChem CID：6020

溶解性：Soluble in water (10 mg/ml)

密度：1.7

敏感性：对光敏感

象形图：

信号词：Warning

危险声明：H373 Causes damage to organs through prolonged or repeated exposure

预防措施声明：P501,P260,P319

个人防护装备：Eyeshields,Gloves,type N95 (US),type P1 (EN143) respirator filter

产品包装