产品名称

英文名称：Reversine

同义词

Reversine、656820-32-5、2-(4-Morpholinoanilino)-6-cyclohexylaminopurine、CHEMBL188343、CHEBI70723、N6-cyclohexyl-N2-(4-morpholinophenyl)-7H-purine-2,6-diamine、N6-cyclohexyl-N2-(4-morpholinophenyl)-9H-purine-2,6-diamine、Z499CLJ023、N~6~-Cyclohexyl-N~2~-(4-Morph

产品性质

CAS编号：656820-32-5

分子式：C21H27N7O

分子量：393.49

MDL号：MFCD07784513

PubChem编号：210332

英文别名：Reversine|656820-32-5|2-(4-Morpholinoanilino)-6-cyclohexylaminopurine|CHEMBL188343|CHEBI70723|N6-cyclohexyl-N2-(4-morpholinophenyl)-7H-purine-2,6-diamine|N6-cyclohexyl-N2-(4-morpholinophenyl)-9H-purine-2,6-diamine|Z499CLJ023|N~6~-Cyclohexyl-N~2~-(4-Morph

规格或纯度：≥97%(HPLC)

英文名称：Reversine

生化机理：Reversine is a cell-permeable, 2,6-disubstituted purine analog that acts as a dedifferentiation-inducing agent. Reversine is shown to induce mouse C2C12 myoblast cells to become multipotent mesenchymal progenitor cells in the concentration range of 1-10 μM. Reversine is also the first organic molecule that has been demonstrated to reverse the cellular differentiation process. The compound acts as a selective A3 adenosine receptor antagonist (Ki= 660 nM, >10 μM, and >10 μM for hA3, hA1, and hA2A, respectively. Reversine functions as a dual inhibitor of MEK1 and nonmuscle myosin II heavy chain (IC50 = 8 and 10 nM, respectively). The compound also acts as an ATP-competitive, reversible and selective inhibitor of ARK-1, ARK-2, and ARK-3 (IC50 = 400, 500 and 400 nM, respectively) in a 26-kinase panel.

储存温度：2-8°C储存

运输条件：冰袋运输

备注：如果有可能，您尽量在使用的当天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，它们最多可以使用一个月。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。

产品介绍：Reversine是合成的嘌呤类似物，能抑制Aurora A/B/C，IC50为150到500 nM。Reversine, a small synthetic purine analogue (2,6-disubstituted purine), is a potent inhibitior of Aurora A/B/C with IC50s of 150-500 nM.

IUPAC Name：6-N-cyclohexyl-2-N-(4-morpholin-4-ylphenyl)-7H-purine-2,6-diamine

INCHI：InChI=1S/C21H27N7O/c1-2-4-15(5-3-1)24-20-18-19(23-14-22-18)26-21(27-20)25-16-6-8-17(9-7-16)28-10-12-29-13-11-28/h6-9,14-15H,1-5,10-13H2,(H3,22,23,24,25,26,27)

InChi Key：ZFLJHSQHILSNCM-UHFFFAOYSA-N

Canonical SMILES：C1CCC(CC1)NC2=NC(=NC3=C2NC=N3)NC4=CC=C(C=C4)N5CCOCC5

Isomeric SMILES：C1CCC(CC1)NC2=NC(=NC3=C2NC=N3)NC4=CC=C(C=C4)N5CCOCC5

WGK Germany：3

PubChem CID：210332

溶解性：DMSO soluble7 mg/mL;H2O insoluble

象形图：

信号词：Warning

危险声明：H302 Harmful if swallowed

预防措施声明：P501,P264,P270,P330,P301+P317

个人防护装备：dust mask type N95 (US), Eyeshields, Gloves

产品包装