产品名称

英文名称：7,8-Dihydroxyflavone Hydrate

同义词

7,8-dihydroxyflavone、38183-03-8、7,8-dihydroxy-2-phenyl-4H-chromen-4-one、7,8-DHF、7,8-Dihydroxyflavone hydrate、4H-1-Benzopyran-4-one, 7,8-dihydroxy-2-phenyl-、7,8-Dihydroxy-flavone、7,8-Dihydroxy-2-phenyl-chromen-4-one、7,8-dihydroxy-2-phenylchromen-4-one、7,8-

产品性质

CAS编号：38183-03-8

分子式：C15H10O4·xH2O

分子量：254.24 (anhydrous basis)

MDL号：MFCD00006836

PubChem编号：1880

英文别名：7,8-dihydroxyflavone|38183-03-8|7,8-dihydroxy-2-phenyl-4H-chromen-4-one|7,8-DHF|7,8-Dihydroxyflavone hydrate|4H-1-Benzopyran-4-one, 7,8-dihydroxy-2-phenyl-|7,8-Dihydroxy-flavone|7,8-Dihydroxy-2-phenyl-chromen-4-one|7,8-dihydroxy-2-phenylchromen-4-one|7,8-

规格或纯度：≥98.0%(HPLC)

英文名称：7,8-Dihydroxyflavone Hydrate

生化机理：7,8-Dihydroxyflavone is a selective tyrosine kinase receptor B (TrkB) receptor agonist. It manifests all the therapeutic effects of brain-derived neurotrophic factor (BDNF)—such as protecting neurons from apoptosis, inhibiting kainic acid-induced toxicity, decreasing infarct volumes in stroke, and neuroprotecting in an animal model of Parkinson′s disease—without the poor pharmacokinetic profile of BDNF limiting its therapeutic potential.Selective TrkB receptor agonist. Flavonoid. Enhances synaptic plasticity in vivo and in vitro. Blood-brain barrier permeable.

储存温度：2-8°C储存,充氩

运输条件：冰袋运输

备注：如果有可能，您尽量在使用的当天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，它们最多可以使用一个月。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。

产品介绍：7,8-Dihydroxyflavone hydrate is a tyrosine kinase receptor B (TrkB) agonist that binds to the extracellular domain of the receptor with a Kd value of 320 nM. It also inhibits glutamate-triggered apoptosis in hippocampal neurons in vitro.7,8-Dihydroxyflavone (7,8-DHF), a selective tyrosine kinase receptor B (neurotrophic factor/tropomyosin-receptor-kinase B; TrkB) agonist, may be used to help identify and differentiate the physiological effects and cell signaling pathways mediated by TrkB activation, such as those involving neuroprotection, memory, vasorelaxation and hypertension. 7,8-Dihydroxyflavone may be used to study its effects on scopolamine induced Alzheimer-like pathologic dysfunction.7,8-Dihydroxyflavone hydrate is a tyrosine kinase receptor B (TrkB) agonist that binds to the extracellular domain of the receptor with a Kd value of 320 nM. It also inhibits glutamate-triggered apoptosis in hippocampal neurons in vitro.7,8-Dihydroxyflavone (7,8-DHF), a selective tyrosine kinase receptor B (neurotrophic factor/tropomyosin-receptor-kinase B; TrkB) agonist, may be used to help identify and differentiate the physiological effects and cell signaling pathways mediated by TrkB activation, such as those involving neuroprotection, memory, vasorelaxation and hypertension. 7,8-Dihydroxyflavone may be used to study its effects on scopolamine induced Alzheimer-like pathologic dysfunction.

IUPAC Name：7,8-dihydroxy-2-phenylchromen-4-one

INCHI：InChI=1S/C15H10O4/c16-11-7-6-10-12(17)8-13(19-15(10)14(11)18)9-4-2-1-3-5-9/h1-8,16,18H

InChi Key：COCYGNDCWFKTMF-UHFFFAOYSA-N

Canonical SMILES：C1=CC=C(C=C1)C2=CC(=O)C3=C(O2)C(=C(C=C3)O)O

Isomeric SMILES：C1=CC=C(C=C1)C2=CC(=O)C3=C(O2)C(=C(C=C3)O)O

RTECS：DJ3004000

PubChem CID：1880

Reaxy-Rn：234350

溶解性：Soluble in water (Partly miscible), alkali hydroxide solutions, and DMSO (24 mg/ml).,

熔点：245 °C

象形图：

信号词：Warning

危险声明：H302 Harmful if swallowed

预防措施声明：P501,P264,P270,P330,P301+P317

产品包装