产品名称

英文名称：Desmopressin

同义词

DDAVP 、 DESMOPRESSIN [MART.] 、 AC-35742 、 Desmopressine (INN-French) 、 EX-A4284 、 DESMOPRESSIN [INN] 、 Desmopressine [INN-French] 、 1-{[(4R,7S,10S,13S,16S)-7-(2-amino-2-oxoethyl)-10-(3-amino-3-oxopropyl)-13-benzyl-16-(4-hydroxybenzyl)-6,9,12,15,18-pentaox、[去氨基-Cys1, D-Arg8]-加压素 乙酸盐 水合物

产品性质

CAS编号：16679-58-6

分子式：C46H64N14O12S2·xC2H4O2·yH2O

分子量：1069.24

EC号：240-726-7

MDL号：MFCD00133962

PubChem编号：5311065

别名：[去氨基-Cys1, D-Arg8]-加压素 乙酸盐 水合物

英文别名：DDAVP | DESMOPRESSIN [MART.] | AC-35742 | Desmopressine (INN-French) | EX-A4284 | DESMOPRESSIN [INN] | Desmopressine [INN-French] | 1-{[(4R,7S,10S,13S,16S)-7-(2-amino-2-oxoethyl)-10-(3-amino-3-oxopropyl)-13-benzyl-16-(4-hydroxybenzyl)-6,9,12,15,18-pentaox

规格或纯度：≥97.0%(HPLC)

英文名称：Desmopressin

生化机理：Desmopressin acetate is the synthetic analogue of the antidiuretic hormone arginine vasopressin. The antidiuretic properties of desmopressin have led to its use in polyuric conditions including primary nocturnal enuresis, nocturia, and diabetes insipidus. Desmopressin works by limiting the amount of water that is eliminated in the urine. Desmopressin binds to V2 receptors in renal collecting ducts, increasing water reabsorption. It also stimulates release of von Willebrand factor from endothelial cells by acting on the V2 receptor.Vasopressin V2 receptor agonist. Has antidiuretic effects in vitro . A modified form of the normal human hormone arginine vasopressin.

储存温度：-20°C储存

运输条件：超低温冰袋运输

备注：如果有可能，您尽量在使用的当天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，这些产品最多可以使用一周。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。

产品介绍：Mpa-Tyr-Phe-Gln-Asn-Cys-Pro-Arg-Gly-NH2 [Disulfide Bridge 1-6]Mpa-Tyr-Phe-Gln-Asn-Cys-Pro-Arg-Gly-NH2 [Disulfide Bridge 1-6]

IUPAC Name：(2S)-N-[(2R)-1-[(2-amino-2-oxoethyl)amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]-1-[(4R,7S,10S,13S,16S)-7-(2-amino-2-oxoethyl)-10-(3-amino-3-oxopropyl)-13-benzyl-16-[(4-hydroxyphenyl)methyl]-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentazacycloicosane-4-carbonyl]pyrrolidine-2-carboxamide

INCHI：InChI=1S/C46H64N14O12S2/c47-35(62)15-14-29-40(67)58-32(22-36(48)63)43(70)59-33(45(72)60-18-5-9-34(60)44(71)56-28(8-4-17-52-46(50)51)39(66)53-23-37(49)64)24-74-73-19-16-38(65)54-30(21-26-10-12-27(61)13-11-26)41(68)57-31(42(69)55-29)20-25-6-2-1-3-7-25/h1-3,6-7,10-13,28-34,61H,4-5,8-9,14-24H2,(H2,47,62)(H2,48,63)(H2,49,64)(H,53,66)(H,54,65)(H,55,69)(H,56,71)(H,57,68)(H,58,67)(H,59,70)(H4,50,51,52)/t28-,29+,30+,31+,32+,33+,34+/m1/s1

InChi Key：NFLWUMRGJYTJIN-PNIOQBSNSA-N

Canonical SMILES：C1CC(N(C1)C(=O)C2CSSCCC(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)N2)CC(=O)N)CCC(=O)N)CC3=CC=CC=C3)CC4=CC=C(C=C4)O)C(=O)NC(CCCN=C(N)N)C(=O)NCC(=O)N

Isomeric SMILES：C1C[C@H](N(C1)C(=O)[C@@H]2CSSCCC(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N2)CC(=O)N)CCC(=O)N)CC3=CC=CC=C3)CC4=CC=C(C=C4)O)C(=O)N[C@H](CCCN=C(N)N)C(=O)NCC(=O)N

WGK Germany：3

关联CAS：16679-58-6 (free base)

PubChem CID：5311065

ChEBI：CHEBI4450

DrugBank Ligand：DB00035

CAS Registry No.：16679-58-6

Wikipedia：Desmopressin

ChEMBL Ligand：CHEMBL264448

GPCRdb Ligand：desmopressin

溶解性：20 mg/mL in H2O

象形图：

信号词：Danger

危险声明：H314 Causes severe skin burns and eye damageH317 May cause an allergic skin reactionH334 May cause allergy or asthma symptoms or breathing difficulties if inhaledH332 Harmful if inhaled

预防措施声明：P261,P280,P302+P352,P321,P405,P501,P264,P260,P284,P271,P301+P330+P331,P304+P340,P363,P272,P333+P313,P362+P364,P305+P354+P338,P317,P302+P361+P354,P316,P342+P316

个人防护装备：dust mask type N95 (US), Eyeshields, Gloves

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