产品名称

英文名称：Scriptaid

同义词

scriptaid、287383-59-9、Scriptide、6-(1,3-Dioxo-1H-benzo[de]isoquinolin-2(3H)-yl)-N-hydroxyhexanamide、GCK 1026、GNF-PF-2024、6-(1,3-dioxobenzo[de]isoquinolin-2-yl)-N-hydroxyhexanamide、Scriptide;GCK1026、1h-benz[de]isoquinoline-2(3h)-hexanamide, n-hydroxy-1,3-di、6-(1,3-二氧代-1H,3H-苯并[de]异喹啉-2-基)-己酸羟基酰胺

产品性质

CAS编号：287383-59-9

分子式：C18H18N2O4

分子量：326.35

PubChem编号：5186

别名：6-(1,3-二氧代-1H,3H-苯并[de]异喹啉-2-基)-己酸羟基酰胺

英文别名：scriptaid|287383-59-9|Scriptide|6-(1,3-Dioxo-1H-benzo[de]isoquinolin-2(3H)-yl)-N-hydroxyhexanamide|GCK 1026|GNF-PF-2024|6-(1,3-dioxobenzo[de]isoquinolin-2-yl)-N-hydroxyhexanamide|Scriptide;GCK1026|1h-benz[de]isoquinoline-2(3h)-hexanamide, n-hydroxy-1,3-di

规格或纯度：≥99%

英文名称：Scriptaid

生化机理：A novel HDAC inhibitor, Scriptaid, has been found to have robust activity and lower toxicity compared to trichostatin A (TSA). Althoμgh Scriptaid induced activation of both p38MAPK and JNK, it was the inhibition of JNK that attenuated Scriptaid-induced apoptosis significantly. Scriptaid also increased the expression of (i) p21 and p27 involved in cell-cycle regulation and (ii) γH2AX associated with DNA damage response in a JNK-dependent manner.Novel HDAC inhibitor, able to cause >100-fold increase in histone deacetylation. Less toxic than trichostatin A. Induces cell cycle arrest in vitro and in vivo.

储存温度：避光,-20°C储存

运输条件：超低温冰袋运输

备注：如果有可能，您尽量在使用的当天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，它们最多可以使用一个月。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。

产品介绍：产品介绍Scriptaid 是一种组蛋白去乙酰化酶 (HDAC) 抑制剂，可用于癌症研究。Scriptaid 也是一种抗病毒药的敏化剂，可用于与爱泼斯坦-巴尔病毒 (EBV) 相关的淋巴瘤的研究。ApplicationScriptaid has been used in post activation of oocytes and embryo culture.Scriptaid was used to enhance transcriptional activity in cloning procedures by somatic cell nuclear transfer.

IUPAC Name：6-(1,3-dioxobenzo[de]isoquinolin-2-yl)-N-hydroxyhexanamide

INCHI：InChI=1S/C18H18N2O4/c21-15(19-24)10-2-1-3-11-20-17(22)13-8-4-6-12-7-5-9-14(16(12)13)18(20)23/h4-9,24H,1-3,10-11H2,(H,19,21)

InChi Key：JTDYUFSDZATMKU-UHFFFAOYSA-N

Canonical SMILES：C1=CC2=C3C(=C1)C(=O)N(C(=O)C3=CC=C2)CCCCCC(=O)NO

Isomeric SMILES：C1=CC2=C3C(=C1)C(=O)N(C(=O)C3=CC=C2)CCCCCC(=O)NO

PubChem CID：5186

CAS Registry No.：287383-59-9

ChEMBL Ligand：CHEMBL96051

溶解性：DMSO 65 mg/mL Water <1 mg/mL Ethanol <1 mg/mL

敏感性：对光线敏感

产品包装