产品名称

英文名称：AG-1024

同义词

65678-07-1、ag1024、Tyrphostin AG 1024、AG-1024、AG 1024、2-(3-Bromo-5-(tert-butyl)-4-hydroxybenzylidene)malononitrile、2-(3-bromo-5-tert-butyl-4-hydroxybenzylidene)malononitrile、2-[(3-bromo-5-tert-butyl-4-hydroxyphenyl)methylidene]propanedinitrile、NF4XN6A8V9、C

产品性质

CAS编号：65678-07-1

分子式：C14H13BrN2O

分子量：305.17

PubChem编号：2044

英文别名：65678-07-1|ag1024|Tyrphostin AG 1024|AG-1024|AG 1024|2-(3-Bromo-5-(tert-butyl)-4-hydroxybenzylidene)malononitrile|2-(3-bromo-5-tert-butyl-4-hydroxybenzylidene)malononitrile|2-[(3-bromo-5-tert-butyl-4-hydroxyphenyl)methylidene]propanedinitrile|NF4XN6A8V9|C

规格或纯度：≥98%

英文名称：AG-1024

生化机理：AG1024 (Tyrphostin AG 1024), one selective inhibitor of IGF-1R, was used to evaluate effects on proliferation, radiosensitivity, and radiation-induced cell apoptosis in a human breast cancer cell line MCF-7. AG1024 inhibited the mitogen-activated protein kinase/extracellular signal-regulated kinase pathway and restored pRb tumor suppressive function. Human breast cancer cell studies report AG1024 to induce apoptosis, inhibit cell proliferation, decrease bcl-2 and phospho-Akt1 expression, and elevate the expression levels of Bax, p53 and p21. Studies report AG1024 to block tyrosine kinase activity and to have a lower IC50 for IGF-1 in comparison to insulin receptors. Other studies indicate that exposure of SHR cells to AG1024 decreases Ang II-mediated NAD(P)H oxidase activation.Selective IGF-1 receptor inhibitor (IC 50 = 7 μM). Potent antiproliferative agent (IC 50 = 50 nM, melanoma cells). Decreases bcl-2 and phospho-Akt1. Increases Bax, p53 and p21. Induces apoptosis and shows antiproliferative effects.

储存温度：-20°C储存

运输条件：超低温冰袋运输

备注：如果有可能，您尽量在使用的当天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，它们最多可以使用一个月。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。

产品介绍：AG-1024 (Tyrphostin)能抑制IGF-1R自磷酸化，IC50为7 μM，而对IR的IC50则为57 μM。AG-1024 (Tyrphostin) inhibits IGF-1R autophosphorylation with IC50 of 7 μM, less potent to IR with IC50 of 57 μM.

IUPAC Name：2-[(3-bromo-5-tert-butyl-4-hydroxyphenyl)methylidene]propanedinitrile

INCHI：InChI=1S/C14H13BrN2O/c1-14(2,3)11-5-9(4-10(7-16)8-17)6-12(15)13(11)18/h4-6,18H,1-3H3

InChi Key：ABBADGFSRBWENF-UHFFFAOYSA-N

Canonical SMILES：CC(C)(C)C1=C(C(=CC(=C1)C=C(C#N)C#N)Br)O

Isomeric SMILES：CC(C)(C)C1=C(C(=CC(=C1)C=C(C#N)C#N)Br)O

PubChem CID：2044

CAS Registry No.：65678-07-1

ChEMBL Ligand：CHEMBL2218926

溶解性：DMSO 61 mg/mL Water <1 mg/mL Ethanol <1 mg/mL

产品包装