产品名称

英文名称：Mycophenolate mofetil

同义词

2-morpholinoethyl (E)-6-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1H-isobenzofuran-5-yl)-4-methyl-hex-4-enoate、AB01274794-01、NSC 724229、RS 61443、2-Morpholinoethyl 6-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydroisobenzofuran-5-yl)-4-methylhex-4-enoate、AB012747、霉酚酸酯

产品性质

CAS编号：128794-94-5

分子式：C23H31NO7

分子量：433.49

MDL号：MFCD00867568

PubChem编号：5281078

别名：霉酚酸酯

英文别名：2-morpholinoethyl (E)-6-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1H-isobenzofuran-5-yl)-4-methyl-hex-4-enoate|AB01274794-01|NSC 724229|RS 61443|2-Morpholinoethyl 6-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydroisobenzofuran-5-yl)-4-methylhex-4-enoate|AB012747

规格或纯度：98%

英文名称：Mycophenolate mofetil

生化机理：霉酚酸（MPA）的免疫抑制前药。被酯酶水解以释放MPA，MPA是肌苷单磷酸脱氢酶（IMPDH）的可逆抑制剂。用于防止移植后器官排斥。显示淋巴细胞功能的抑制活性。抑制1型胶原蛋白表达，增强MMP-1表达，并降低α-平滑肌肌动蛋白基因表达。

应用：霉酚酸酯是由非特异性酯酶在体内裂解产生母体化合物霉酚酸的前药。霉酚酸阻断肌苷单磷酸脱氢酶，是一种有效的免疫抑制剂。

运输条件：常规运输

备注：250mg卖完停产，不再备货

产品介绍：霉酚酸酯是由非特异性酯酶在体内裂解产生母体化合物霉酚酸的前药。霉酚酸阻断肌苷单磷酸脱氢酶，是一种有效的免疫抑制剂。Mycophenolate mofetil is a prodrug of mycophenolic acid that is cleaved by nonspecific esterases in vivo to produce the parent compound. Mycophenolic acid blocks inosine monophosphate dehydrogenase and is a potent immunosuppresive agent.

IUPAC Name：2-morpholin-4-ylethyl (E)-6-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1H-2-benzofuran-5-yl)-4-methylhex-4-enoate

INCHI：InChI=1S/C23H31NO7/c1-15(5-7-19(25)30-13-10-24-8-11-29-12-9-24)4-6-17-21(26)20-18(14-31-23(20)27)16(2)22(17)28-3/h4,26H,5-14H2,1-3H3/b15-4+

InChi Key：RTGDFNSFWBGLEC-SYZQJQIISA-N

Canonical SMILES：CC1=C2COC(=O)C2=C(C(=C1OC)CC=C(C)CCC(=O)OCCN3CCOCC3)O

Isomeric SMILES：CC1=C2COC(=O)C2=C(C(=C1OC)C/C=C(\C)/CCC(=O)OCCN3CCOCC3)O

WGK Germany：3

PubChem CID：5281078

DrugBank Ligand：DB00688

CAS Registry No.：128794-94-5

Wikipedia：Mycophenolate_mofetil

ChEMBL Ligand：CHEMBL1456

Immunopaedia Search：mycophenolate mofetil

DrugCentral Ligand：1859

溶解性：溶于DMSO, 最高浓度 (mg/mL) 43.35, 最高浓度(mM) 100；溶于ethanol, 最高浓度 (mg/mL) 4.33, 最高浓度(mM) 10

密度：1.222

熔点：96 °C

象形图：

信号词：Danger

危险声明：H341 Suspected of causing genetic defectsH302 Harmful if swallowedH400 Very toxic to aquatic lifeH410 Very toxic to aquatic life with long lasting effectsH372 Causes damage to organs through prolonged or repeated exposureH360 May damage fertility or the unborn child

预防措施声明：P273,P280,P405,P501,P264,P260,P281,P270,P391,P330,P203,P301+P317,P318,P319

Merck Index：6327

产品包装