产品名称

英文名称：Rebamipide

同义词

rebamipide、90098-04-7、Proamipide、Mucosta、111911-87-6、OPC-12759、Rebamipide hydrate、139344-42-6、Pramipide、Rebator、2-(4-Chlorobenzoylamino)-3-(1,2-dihydro-2-oxo-4-quinolyl)propionic acid、2-[(4-chlorobenzoyl)amino]-3-(2-oxo-1H-quinolin-4-yl)propanoic acid、NSC、瑞巴派特、2-(4-氯苯甲酰胺基)-3-[2(1H)-喹啉酮-4-基]丙酸

产品性质

CAS编号：90098-04-7

分子式：C19H15ClN2O4.xH2O

分子量：370.79

MDL号：MFCD11114396

PubChem编号：5042

别名：瑞巴派特|2-(4-氯苯甲酰胺基)-3-[2(1H)-喹啉酮-4-基]丙酸

英文别名：rebamipide|90098-04-7|Proamipide|Mucosta|111911-87-6|OPC-12759|Rebamipide hydrate|139344-42-6|Pramipide|Rebator|2-(4-Chlorobenzoylamino)-3-(1,2-dihydro-2-oxo-4-quinolyl)propionic acid|2-[(4-chlorobenzoyl)amino]-3-(2-oxo-1H-quinolin-4-yl)propanoic acid|NSC

规格或纯度：≥98%

英文名称：Rebamipide

生化机理：Rebamipide enhances mucosal resistance, increases prostaglandin in gastric mucosa, and also scavenges oxygen-derived free radicals and inhibits their production.Derivative of 2-(1 H )-quinolinone with multiple biological activities. Stimulates prostaglandin and mucus glycoprotein synthesis. Inhibits ROS and inflammatory cytokine release. Also, increases COX-2 and HSP70 expression.

应用：An inducer of endogenous prostaglandin and a oxygen-derived free radical scavenger.

运输条件：常规运输

备注：如果有可能，您尽量在使用的当天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，它们最多可以使用一个月。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。

产品介绍：Rebamipide 是胆囊收缩素-1(CCK1)受体抑制剂，抑制[125I]BH-CCK-8S，IC50为37.7 μM。产品介绍Rebamipide 是一种粘膜保护剂。Rebamipide 诱导 COX-2 表达，增加 PGE2 水平，且以 COX-2 依赖性方式增强胃粘膜防御。Rebamipide is a cholecystokinin type 1 (CCK1) receptor inhibitor for inhibiting [125I]BH-CCK-8S with IC50 of 37.7 μM.An inducer of endogenous prostaglandin and a oxygen-derived free radical scavenger.product descriptionRebamipide is a mucoprotective agent. Rebamipide induces COX-2 expression, increases PGE2 levels, and enhances gastric mucosal defense in a COX-2-dependent manner；

PubChem SID：488179871

PubChem SID url：https//pubchem.ncbi.nlm.nih.gov/substance/488179871

IUPAC Name：2-[(4-chlorobenzoyl)amino]-3-(2-oxo-1H-quinolin-4-yl)propanoic acid

INCHI：InChI=1S/C19H15ClN2O4/c20-13-7-5-11(6-8-13)18(24)22-16(19(25)26)9-12-10-17(23)21-15-4-2-1-3-14(12)15/h1-8,10,16H,9H2,(H,21,23)(H,22,24)(H,25,26)

InChi Key：ALLWOAVDORUJLA-UHFFFAOYSA-N

Canonical SMILES：C1=CC=C2C(=C1)C(=CC(=O)N2)CC(C(=O)O)NC(=O)C3=CC=C(C=C3)Cl

Isomeric SMILES：C1=CC=C2C(=C1)C(=CC(=O)N2)CC(C(=O)O)NC(=O)C3=CC=C(C=C3)Cl

RTECS：VC2518500

PubChem CID：5042

Reaxy-Rn：5384689

Wikipedia：Rebamipide

CAS Registry No.：90098-04-7

ChEMBL Ligand：CHEMBL1697771

DrugCentral Ligand：2360

GPCRdb Ligand：rebamipide

溶解性：Soluble in DMSO (74 mg/mL at 25 °C), methanol (Heat), water (<1 mg/mL at 25 °C), and ethanol (<1 mg/mL at 25 °C).

熔点：290°C(dec.)(lit.)

象形图：

信号词：Danger

危险声明：H301 Toxic if swallowed

预防措施声明：P321,P405,P501,P264,P270,P330,P301+P316

Merck Index：8124

产品包装