产品名称

英文名称：Ketanserin

同义词

R-49945、SW196882-3、3-(2-(4-(4-Fluorobenzoyl)piperidinol)ethyl)-2,4(1H,3H)-quinazolinedione、R 41468、Tox21_110865_1、Ketanserine、Ketanserinum、Ketanserinum [INN-Latin]、C22H22FN3O3、Ketanserin tartrate、NCGC00024865-02、NCGC00021146-03、A838000、C07464、Serepress、3-、酮色林

产品性质

CAS编号：74050-98-9

分子式：C22H22FN3O3

分子量：395.43

EC号：281-062-8,277-680-2

MDL号：MFCD00083392

PubChem编号：3822

别名：酮色林

英文别名：R-49945|SW196882-3|3-(2-(4-(4-Fluorobenzoyl)piperidinol)ethyl)-2,4(1H,3H)-quinazolinedione|R 41468|Tox21_110865_1|Ketanserine|Ketanserinum|Ketanserinum [INN-Latin]|C22H22FN3O3|Ketanserin tartrate|NCGC00024865-02|NCGC00021146-03|A838000|C07464|Serepress|3-

规格或纯度：≥97%

英文名称：Ketanserin

生化机理：Ketanserin is reported to have a high affinity for multiple G protein-coupled receptors, such as serotonin receptors. Ketanserin is a selective serotonin 5-HT2/5-HT1C antagonist. It has been used to distinguish between 5-HT1D and 5-HT1B receptor subtypes. Additional studies have noted that Ketanserin is able to differentiate between recombinant human forms of these receptors with a higher affinity for 5-HT1Dα receptors compared to 5-HT1Dβ receptors.Potent, selective 5-HT 2A/1D receptor antagonist (K i values are 3-15 nM and 24-27 nM respectively). Orally active.

应用：A selective serotonin antagonist.

储存温度：-20°C储存

运输条件：超低温冰袋运输

备注：如果有可能，您尽量在使用的当天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，它们最多可以使用一个月。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。

产品介绍：Ketanserin 是一种特异性的5-HT2A 5-羟色胺受体拮抗剂，作用于大鼠和人5-HT2A，Ki为2.5 nM。A selective serotonin antagonist.Ketanserin is a specific 5-HT2A serotonin receptor antagonist with Ki of 2.5 nM for rat and human 5-HT2A, used as an antihypertensive drug.A selective serotonin antagonist.

PubChem SID：488179797

PubChem SID url：https//pubchem.ncbi.nlm.nih.gov/substance/488179797

IUPAC Name：3-[2-[4-(4-fluorobenzoyl)piperidin-1-yl]ethyl]-1H-quinazoline-2,4-dione

INCHI：InChI=1S/C22H22FN3O3/c23-17-7-5-15(6-8-17)20(27)16-9-11-25(12-10-16)13-14-26-21(28)18-3-1-2-4-19(18)24-22(26)29/h1-8,16H,9-14H2,(H,24,29)

InChi Key：FPCCSQOGAWCVBH-UHFFFAOYSA-N

Canonical SMILES：C1CN(CCC1C(=O)C2=CC=C(C=C2)F)CCN3C(=O)C4=CC=CC=C4NC3=O

Isomeric SMILES：C1CN(CCC1C(=O)C2=CC=C(C=C2)F)CCN3C(=O)C4=CC=CC=C4NC3=O

RTECS：VA1411190

关联CAS：74050-98-9,83846-83-7

PubChem CID：3822

NSC Number：758959

MeSH Entry Terms：3-(2-(4-(4-Fluorobenzoyl)piperidinol)ethyl)-2,4(1H,3H)-quinazolinedione;Ketanserin;R 41,468;R 41468;R-41,468;R-41468;R41,468;R41468

Reaxy-Rn：4913068

ChEBI：CHEBI6123

CAS Registry No.：74050-98-9

Wikipedia：Ketanserin

ChEMBL Ligand：CHEMBL51

DrugCentral Ligand：1524

GPCRdb Ligand：ketanserin

溶解性：Soluble in water (<1 mg/ml at 25 °C), DMSO (2 mg/ml at 25 °C), ethanol (<1 mg/ml at 25 °C), DMF (10 mg/ml), and methanol.

敏感性：对热敏感

熔点：228-232°C

象形图：

信号词：Danger

危险声明：H301 Toxic if swallowedH302 Harmful if swallowed

预防措施声明：P321,P405,P501,P264,P270,P330,P301+P316,P301+P317

Merck Index：5296

产品包装