产品名称

英文名称：Manidipine 2HCl

同义词

Manidipine dihydrochloride、89226-75-5、manidipine hydrochloride、Manidipine 2HCl、CV-4093、Manidipine HCl、Calslot、ManidipineHcl、Franidipine hydrochloride、Manidipine (dihydrochloride)、Manidipine.2HCl、126229-12-7、3-(2-(4-Benzhydrylpiperazin-1-yl)ethyl) 5-methyl、盐酸美尼地平、1,4-二氢-2,6-二甲基-4-(3-硝基苯基)-3,5-吡啶二羧酸-2-[4-(二苯基甲基)-1-哌嗪基]乙基甲基酯二盐酸盐、2-[4-(二苯基甲基)-1-哌嗪基]乙基甲基-1,4-二氢-2,6-二甲基-4-(3-硝基苯基)-3,5-吡啶二甲酸酯二盐酸盐、马尼地平二盐酸盐

产品性质

CAS编号：89226-75-5

分子式：C35H38N4O6·2HCl

分子量：683.62

MDL号：MFCD00896434

PubChem编号：150762

别名：盐酸美尼地平|1,4-二氢-2,6-二甲基-4-(3-硝基苯基)-3,5-吡啶二羧酸-2-[4-(二苯基甲基)-1-哌嗪基]乙基甲基酯二盐酸盐|2-[4-(二苯基甲基)-1-哌嗪基]乙基甲基-1,4-二氢-2,6-二甲基-4-(3-硝基苯基)-3,5-吡啶二甲酸酯二盐酸盐|马尼地平二盐酸盐

英文别名：Manidipine dihydrochloride|89226-75-5|manidipine hydrochloride|Manidipine 2HCl|CV-4093|Manidipine HCl|Calslot|ManidipineHcl|Franidipine hydrochloride|Manidipine (dihydrochloride)|Manidipine.2HCl|126229-12-7|3-(2-(4-Benzhydrylpiperazin-1-yl)ethyl) 5-methyl

规格或纯度：≥99%

英文名称：Manidipine 2HCl

生化机理：Manidipine dihydrochloride is a dihydropyridine compound and a calcium channel blocker for Ca2+ current with IC50 of 2.6 nM. Manidipine is described to block T-type Ca2+ channels specifically and is also described to have a high selectivity for the vasculature, presenting negligible cardiodepression as compared to other Ca2+ channel antagonists. Manidipine is also described to not significantly affect norepinephrine levels, sμggesting a lack of sympathetic activation with this compound. Manidipine reduces pro-inflammatory cytokines secretion in human endothelial cells and macrophages. Manidipine, unlike other third-generation dihydropyridine derived drμgs, blocks T-type calcium channels present in the efferent glomerular arterioles, reducing intraglomerular pressure and microalbuminuria.Potent calcium channel blocker (IC 50 = 2.6 nM). Suppresses proliferation and stimulates glycosaminoglycan synthesis in vitro . Antihypertensive agent. Orally active. Active in vitro and in vivo .

储存温度：-20°C储存

运输条件：超低温冰袋运输

备注：如果有可能，您尽量在使用的当天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，它们最多可以使用一个月。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。有毒，请参阅SDS以获取更多信息。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。

产品介绍：产品介绍Manidipine dihydrochloride (CV-4093) 是钙离子通道阻断剂，能抑制钙流，IC50为2.6 nM。

IUPAC Name：5-O-[2-(4-benzhydrylpiperazin-1-yl)ethyl] 3-O-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate;dihydrochloride

INCHI：InChI=1S/C35H38N4O6.2ClH/c1-24-30(34(40)44-3)32(28-15-10-16-29(23-28)39(42)43)31(25(2)36-24)35(41)45-22-21-37-17-19-38(20-18-37)33(26-11-6-4-7-12-26)27-13-8-5-9-14-27;;/h4-16,23,32-33,36H,17-22H2,1-3H3;2*1H

InChi Key：JINNGBXKBDUGQT-UHFFFAOYSA-N

Canonical SMILES：CC1=C(C(C(=C(N1)C)C(=O)OCCN2CCN(CC2)C(C3=CC=CC=C3)C4=CC=CC=C4)C5=CC(=CC=C5)[N+](=O)[O-])C(=O)OC.Cl.Cl

Isomeric SMILES：CC1=C(C(C(=C(N1)C)C(=O)OCCN2CCN(CC2)C(C3=CC=CC=C3)C4=CC=CC=C4)C5=CC(=CC=C5)[N+](=O)[O-])C(=O)OC.Cl.Cl

RTECS：US7975300

PubChem CID：150762

Reaxy-Rn：5710369

溶解性：DMSO 21 mg/mL Water <1 mg/mL Ethanol <1 mg/mL

熔点：211 °C(dec.)

象形图：

信号词：Danger

危险声明：H335 May cause respiratory irritationH301 Toxic if swallowedH311 Toxic in contact with skinH331 Toxic if inhaledH373 Causes damage to organs through prolonged or repeated exposureH361 Suspected of damaging fertility or the unborn childH301+H311+H331 Toxic if swallowed, in contact with skin or if inhaled

预防措施声明：P261,P280,P302+P352,P321,P405,P501,P264,P260,P271,P270,P304+P340,P403+P233,P330,P361+P364,P203,P301+P316,P318,P316,P319

Merck Index：5743

产品包装