产品名称

英文名称：Pentoxifylline

同义词

pentoxifylline、Trental、6493-05-6、Oxpentifylline、Pentoxifyllin、Pentoxyphylline、Torental、Pentoxiphyllium、Vazofirin、Dimethyloxohexylxanthine、3,7-Dimethyl-1-(5-oxohexyl)xanthine、Pentoxiphyllin、Pentoxiphylline、Pentoxyfylline、1-(5-Oxohexyl)theobromine、Rentylin、3,7-二甲基-1-(5-氧代己基)黄嘌呤、3,7-二氢-3,7-二甲基-1-(5-氧代己基)-1H-嘌呤-2,6-二酮、1-(5-氧代己基)可可碱

产品性质

CAS编号：6493-05-6

分子式：C13H18N4O3

分子量：278.31

MDL号：MFCD00063379

PubChem编号：4740

别名：3,7-二甲基-1-(5-氧代己基)黄嘌呤|3,7-二氢-3,7-二甲基-1-(5-氧代己基)-1H-嘌呤-2,6-二酮|1-(5-氧代己基)可可碱

英文别名：pentoxifylline|Trental|6493-05-6|Oxpentifylline|Pentoxifyllin|Pentoxyphylline|Torental|Pentoxiphyllium|Vazofirin|Dimethyloxohexylxanthine|3,7-Dimethyl-1-(5-oxohexyl)xanthine|Pentoxiphyllin|Pentoxiphylline|Pentoxyfylline|1-(5-Oxohexyl)theobromine|Rentylin|

规格或纯度：>98.0%

英文名称：Pentoxifylline

生化机理：磷酸二酯酶抑制剂。抑制TNF-α的合成。广谱细胞因子抑制剂。显示出抗炎和镇痛特性。

储存温度：-20°C储存

运输条件：超低温冰袋运输

备注：如果有可能，您尽量在使用的当天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，它们最多可以使用一个月。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。

产品介绍：Pentoxifylline is a competitive nonselective phosphodiesterase inhibitor. Target PDE Pentoxifylline is a competitive nonselective phosphodiesterase inhibitor which raises intracellular cAMP, activates PKA, inhibits TNF and leukotriene synthesis, and reduces inflammation and innate immunity. In addition, pentoxifylline improves red blood cell deformability, reduces blood viscosity and decreases the potential for platelet aggregation and thrombus formation. Pentoxifylline is also an antagonist at adenosine 2 receptors . Pentoxifylline is generally well tolerated. Based on the totality of the available evidence, it is possible that pentoxifylline could have a place in the treatment of IC as a means of improving walking distance and as a complimentary treatment assuming all other essential measures such as lifestyle change, exercise and treatment for secondary prevention have been taken into account . Pentoxifylline reduce AST and ALT levels and may improve liver histological scores in patients with NALFD/NASH, but did not appear to affect cytokines. Large, prospective, and well-designed randomized, controlled studies are needed to address this issue .Pentoxifylline是竞争性非选择性磷酸二酯酶（PDE）抑制剂Pentoxifylline is a competitive nonselective phosphodiesterase inhibitor. Target PDE Pentoxifylline is a competitive nonselective phosphodiesterase inhibitor which raises intracellular cAMP, activates PKA, inhibits TNF and leukotriene synthesis, and reduces inflammation and innate immunity. In addition, pentoxifylline improves red blood cell deformability, reduces blood viscosity and decreases the potential for platelet aggregation and thrombus formation. Pentoxifylline is also an antagonist at adenosine 2 receptors . Pentoxifylline is generally well tolerated. Based on the totality of the available evidence, it is possible that pentoxifylline could have a place in the treatment of IC as a means of improving walking distance and as a complimentary treatment assuming all other essential measures such as lifestyle change, exercise and treatment for secondary prevention have been taken into account . Pentoxifylline reduce AST and ALT levels and may improve liver histological scores in patients with NALFD/NASH, but did not appear to affect cytokines. Large, prospective, and well-designed randomized, controlled studies are needed to address this issue .

ALogP：0.3

IUPAC Name：3,7-dimethyl-1-(5-oxohexyl)purine-2,6-dione

INCHI：InChI=1S/C13H18N4O3/c1-9(18)6-4-5-7-17-12(19)10-11(14-8-15(10)2)16(3)13(17)20/h8H,4-7H2,1-3H3

InChi Key：BYPFEZZEUUWMEJ-UHFFFAOYSA-N

Canonical SMILES：CC(=O)CCCCN1C(=O)C2=C(N=CN2C)N(C1=O)C

Isomeric SMILES：CC(=O)CCCCN1C(=O)C2=C(N=CN2C)N(C1=O)C

RTECS：XH2475000

PubChem CID：4740

Reaxy-Rn：558929

DrugBank Ligand：DB00806

CAS Registry No.：6493-05-6

ChEMBL Ligand：CHEMBL628

Wikipedia：Pentoxifylline

RCSB PDB Ligand：PNX

PEP：pentoxifylline

DrugCentral Ligand：2099

GPCRdb Ligand：pentoxifylline

熔点：105 °C

象形图：

信号词：Warning

危险声明：H302 Harmful if swallowed

预防措施声明：P501,P264,P270,P330,P301+P317

Merck Index：7136

产品包装