产品名称

英文名称：AM630

同义词

164178-33-0、AM630、(6-iodo-2-methyl-1-(2-morpholinoethyl)-1H-indol-3-yl)(4-methoxyphenyl)methanone、AM-630、6-iodopravadoline、iodopravadoline、AM 630、Iodopravadoline (AM630)、[6-iodo-2-methyl-1-(2-morpholin-4-ylethyl)indol-3-yl]-(4-methoxyphenyl)methanone、U1LN

产品性质

CAS编号：164178-33-0

分子式：C23H25IN2O3

分子量：504.36

EC号：803-134-5

MDL号：MFCD01861183

PubChem编号：4302963

英文别名：164178-33-0|AM630|(6-iodo-2-methyl-1-(2-morpholinoethyl)-1H-indol-3-yl)(4-methoxyphenyl)methanone|AM-630|6-iodopravadoline|iodopravadoline|AM 630|Iodopravadoline (AM630)|[6-iodo-2-methyl-1-(2-morpholin-4-ylethyl)indol-3-yl]-(4-methoxyphenyl)methanone|U1LN

规格或纯度：≥97%

英文名称：AM630

生化机理：AM630 is a selectivity CB2 antagonist with Ki of 31.2 nM; > 150 fold selectivity over CB1 receptor. AM630 is a selective CB2 receptor antagonist that binds to CB1 and CB2 receptors with Ki values of 5.2 uM and 31.2 nM, respectively. AM630 has been shown to display 165-fold selectivity over CB1 receptors and behave as a weak partial/inverse agonist at CB1 receptors. AM630 acts as a cannabinoid receptor antagonist in mouse brain, vas deferens and guinea pig brain, but acts as an agonist in guinea pig leum. AM630 acts as an inverse agonist on cloned human CB1 receptors.

储存温度：2-8°C储存

运输条件：冰袋运输

产品介绍：AM630是CB2拮抗剂，Ki为31.2 nM，比对CB1受体的抑制性高150倍以上。A selective CB2 receptor antagonist that binds to CB1 and CB2 receptorsAM-630 is a selective CB2 receptor antagonist that binds to CB1 and CB2 receptors with Ki values of 5.2 μM and 31.2 nM, respectively. AM630 has been shown to display 165-fold selectivity over CB1 receptors and behave as a weak partial/inverse agonist at CB1 receptors. AM-630 acts as an inverse agonist on cloned human CB1 receptors.A selective CB2 receptor antagonist that binds to CB1 and CB2 receptors

IUPAC Name：[6-iodo-2-methyl-1-(2-morpholin-4-ylethyl)indol-3-yl]-(4-methoxyphenyl)methanone

INCHI：InChI=1S/C23H25IN2O3/c1-16-22(23(27)17-3-6-19(28-2)7-4-17)20-8-5-18(24)15-21(20)26(16)10-9-25-11-13-29-14-12-25/h3-8,15H,9-14H2,1-2H3

InChi Key：JHOTYHDSLIUKCJ-UHFFFAOYSA-N

Canonical SMILES：CC1=C(C2=C(N1CCN3CCOCC3)C=C(C=C2)I)C(=O)C4=CC=C(C=C4)OC

Isomeric SMILES：CC1=C(C2=C(N1CCN3CCOCC3)C=C(C=C2)I)C(=O)C4=CC=C(C=C4)OC

WGK Germany：3

关联CAS：164178-33-0

PubChem CID：4302963

MeSH Entry Terms：1-(2-(morpholin-4-yl)ethyl)-2-methyl-3-(4-methoxybenzoyl)-6-iodoindole;2-methyl-3-(4-methoxybenzoyl)-6-iodo-1-(2-morpholinoethyl)-1H-indole;6-iodopravadoline;AM 630;AM-630;AM630;iodopravadoline;methanone, (6-iodo-2-methyl-1-(2-(4-morpholinyl)ethyl)-1H-ind

溶解性：Soluble in DMSO, DMF, ethanol, water (0.2 mg/ml) at 25 °C, and 14 DMFPBS(pH 7.2) (0.2 mg/ml).

密度：1.5

折光率：1.65

沸点：605.93 °C at 760 mmHg

象形图：

信号词：Warning

危险声明：H400 Very toxic to aquatic lifeH410 Very toxic to aquatic life with long lasting effects

预防措施声明：P273,P501,P391

产品包装