产品名称

英文名称：D-Penicillamine

同义词

Cuprimine (TN)、Penicillaminum (INN-Latin)、D-Valine, 3-mercapto-、KBioSS_000763、PENICILLAMINE [INN]、Spectrum2_001029、Artamine、Cupripen、Kuprenil、PENICILLAMINE (EP IMPURITY)、PENICILLAMINE [MART.]、Penicillaminum [INN-Latin]、Sufortan、3-Mercapto-D-valine、D-3-Mer、D-(-)-青霉胺

产品性质

CAS编号：52-67-5

分子式：C5H11NO2S

分子量：149.21

Beilstein号：1722375

EC号：200-148-8

MDL号：MFCD00064302

PubChem编号：5852

别名：D-(-)-青霉胺

英文别名：Cuprimine (TN)|Penicillaminum (INN-Latin)|D-Valine, 3-mercapto-|KBioSS_000763|PENICILLAMINE [INN]|Spectrum2_001029|Artamine|Cupripen|Kuprenil|PENICILLAMINE (EP IMPURITY)|PENICILLAMINE [MART.]|Penicillaminum [INN-Latin]|Sufortan|3-Mercapto-D-valine|D-3-Mer

规格或纯度：>98.0%(T)

英文名称：D-Penicillamine

生化机理：Penicillamine is a characteristic degradation product of penicillin type antibiotics. One atom of copper combines with two molecules of penicillamine. Penicillamine reduces excess cystine excretion in cystinuria. This is by disulfide interchange between penicillamine and cystine, which results in formation of a readily excreted penicillamine-cysteine disulfide. Penicillamine interferes with the formation of cross-links between tropocollagen molecules and cleaves them when newly formed. Penicillamine lowers IgM rheumatoid factor and depresses T-cell activity.Copper chelator. Structural analog of cysteine and metabolite of penicillin. Displays a variety of biological effects. Acts as an immunosuppressant and shows antirheumatic effect. Active in vivo .

储存温度：2-8°C储存

运输条件：冰袋运输

备注：如果有可能，您尽量在使用的当天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，它们最多可以使用一个月。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。

产品介绍：Penicillamine is an exogenous NOS modulator, found to inhibit urease activity.It is used as an antirheumatic and as a chelating agent in Wilson′s disease. It is used as a copper chelator to form mixed disulfides with cysteine or other sulfide media components. It is used to inactivate protein-1 DNA binding and to inhibit the growth of asynchronous cultures of rabbit articular chondrocytes.Penicillamine is an exogenous NOS modulator, found to inhibit urease activity.It is used as an antirheumatic and as a chelating agent in Wilson′s disease. It is used as a copper chelator to form mixed disulfides with cysteine or other sulfide media components. It is used to inactivate protein-1 DNA binding and to inhibit the growth of asynchronous cultures of rabbit articular chondrocytes.

ALogP：-1.8

IUPAC Name：(2S)-2-amino-3-methyl-3-sulfanylbutanoic acid

INCHI：InChI=1S/C5H11NO2S/c1-5(2,9)3(6)4(7)8/h3,9H,6H2,1-2H3,(H,7,8)/t3-/m0/s1

InChi Key：VVNCNSJFMMFHPL-VKHMYHEASA-N

Canonical SMILES：CC(C)(C(C(=O)O)N)S

Isomeric SMILES：CC(C)([C@H](C(=O)O)N)S

WGK Germany：2

RTECS：YV9425000

PubChem CID：5852

Reaxy-Rn：1722375

DrugBank Ligand：DB00859

CAS Registry No.：52-67-5

ChEMBL Ligand：CHEMBL1430

Wikipedia：Penicillamine

RCSB PDB Ligand：LEI

PEP：penicillamine

DrugCentral Ligand：2081

溶解性：Soluble in water (30 mg/ml at 25° C), ethanol (<1 mg/ml at 25° C), methanol, and DMSO (<1 mg/ml at 25° C)

密度：1.2

敏感性：对热敏感

折光率：1.53

比旋光度：-63o

沸点：251.8° C

熔点：210°C

象形图：

信号词：Warning

危险声明：H315 Causes skin irritationH319 Causes serious eye irritationH335 May cause respiratory irritation

预防措施声明：P261,P305+P351+P338,P280,P302+P352,P321,P405,P501,P264,P271,P304+P340,P403+P233,P362+P364,P264+P265,P337+P317,P332+P317,P319

Merck Index：7088

个人防护装备：dust mask type N95 (US),Eyeshields,Gloves

产品包装