产品名称

英文名称：Atomoxetine HCl

同义词

Atomoxetine hydrochloride、Atomoxetine HCL、82248-59-7、TOMOXETINE HYDROCHLORIDE、Strattera、(R)-Tomoxetine hydrochloride、(R)-N-Methyl-3-phenyl-3-(o-tolyloxy)propan-1-amine hydrochloride、(R)-(-)-Tomoxetine hydrochloride、Atomoxetine hydrochloride [USAN]、LY 1396、盐酸托莫西汀、盐酸托莫西汀、盐酸阿托莫西汀、(R)-N-甲基-3-(2-甲基苯氧基)-3-苯丙基胺盐酸盐

产品性质

CAS编号：82248-59-7

分子式：C17H21NO·HCl

分子量：291.82

EC号：200-659-6

MDL号：MFCD06410992

PubChem编号：54840

别名：盐酸托莫西汀|盐酸托莫西汀|盐酸阿托莫西汀|(R)-N-甲基-3-(2-甲基苯氧基)-3-苯丙基胺盐酸盐

英文别名：Atomoxetine hydrochloride|Atomoxetine HCL|82248-59-7|TOMOXETINE HYDROCHLORIDE|Strattera|(R)-Tomoxetine hydrochloride|(R)-N-Methyl-3-phenyl-3-(o-tolyloxy)propan-1-amine hydrochloride|(R)-(-)-Tomoxetine hydrochloride|Atomoxetine hydrochloride [USAN]|LY 1396

规格或纯度：≥98%

英文名称：Atomoxetine HCl

生化机理：Tomoxetine hydrochloride (Atomoxetine, LY 139603) is a competitive and specific inhibitor of SLC6A2 while demonstrating weak ST and DAT inhibition as studied in synaptosomes of rat hypothalamus. Additionally, studies indicate that this (-) optical isomer is more effective than the (+) isomer, LY139602 (ent S-(+)-Atomoxetine Hydrochloride;). In the prefrontal cortex of rats, Tomoxetine was reported to not cause an increase in dopamine within the striatum or nucleus accumbens which may be useful in additional research studies investigating the reward pathways of the brain. Tomoxetine hydrochloride is an inhibitor of NMDA.Potent and selective norepinephrine reuptake inhibitor. K i values are 5, 77 and 1451 nM for inhibitors NET, DAT and SERT, respectively. Increases extraneuronal norepinephrine and dopamine levels within brain regions associated with Attention Deficit Hype

应用：A selective SLC6A2 inhibitor.

储存温度：-20°C储存

运输条件：超低温冰袋运输

备注：如果有可能，您尽量在使用的当天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，它们最多可以使用一个月。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。有毒，请参阅SDS以获取更多信息。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。

产品介绍：Atomoxetine HCl是一种选择性的去甲肾上腺素(NE)转运体抑制剂，Ki为5 nM，作用于人体5-HT和DA转运体亲和力比其低15和290倍。A selective SLC6A2 inhibitor.Atomoxetine is a selective norepinephrine (NE) transporter inhibitor with Ki of 5 nM, with 15- and 290-fold lower affinity for human 5-HT and DA transporters.A selective SLC6A2 inhibitor.

IUPAC Name：(3R)-N-methyl-3-(2-methylphenoxy)-3-phenylpropan-1-amine;hydrochloride

INCHI：InChI=1S/C17H21NO.ClH/c1-14-8-6-7-11-16(14)19-17(12-13-18-2)15-9-4-3-5-10-15;/h3-11,17-18H,12-13H2,1-2H3;1H/t17-;/m1./s1

InChi Key：LUCXVPAZUDVVBT-UNTBIKODSA-N

Canonical SMILES：CC1=CC=CC=C1OC(CCNC)C2=CC=CC=C2.Cl

Isomeric SMILES：CC1=CC=CC=C1O[C@H](CCNC)C2=CC=CC=C2.Cl

WGK Germany：1

关联CAS：83015-26-3

PubChem CID：54840

Reaxy-Rn：5318974

溶解性：DMSO 58 mg/mL Water 2 mg/mL Ethanol 37 mg/mL

敏感性：对热和湿度敏感

比旋光度：-42° (C=1,MeOH)

熔点：167.0 - 171.0 °C

象形图：

信号词：Danger

危险声明：H319 Causes serious eye irritationH301 Toxic if swallowedH311 Toxic in contact with skinH331 Toxic if inhaledH373 Causes damage to organs through prolonged or repeated exposureH411 Toxic to aquatic life with long lasting effectsH302 Harmful if swallowedH318 Causes serious eye damageH336 May cause drowsiness or dizzinessH400 Very toxic to aquatic lifeH410 Very toxic to aquatic life with long lasting effectsH330 Fatal if inhaledH361 Suspected of damaging fertility or the unborn child

预防措施声明：P261,P305+P351+P338,P273,P280,P302+P352,P321,P405,P501,P264,P260,P284,P271,P270,P304+P340,P403+P233,P391,P330,P320,P361+P364,P203,P264+P265,P301+P316,P301+P317,P305+P354+P338,P318,P317,P337+P317,P316,P319

Merck Index：863

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