产品名称

英文名称：LDN-57444

同义词

LDN-57444、668467-91-2、CID 16760696、CHEMBL3407553、(Z)-3-(acetoxyimino)-5-chloro-1-(2,5-dichlorobenzyl)indolin-2-one、LDN 57444、[(Z)-[5-chloro-1-[(2,5-dichlorophenyl)methyl]-2-oxoindol-3-ylidene]amino] acetate、LDN57444、5-Chloro-1-[(2,5-dichlorophenyl)methyl]

产品性质

CAS编号：668467-91-2

分子式：C17H11Cl3N2O3

分子量：397.64

MDL号：MFCD09037562

PubChem编号：16760696

英文别名：LDN-57444|668467-91-2|CID 16760696|CHEMBL3407553|(Z)-3-(acetoxyimino)-5-chloro-1-(2,5-dichlorobenzyl)indolin-2-one|LDN 57444|[(Z)-[5-chloro-1-[(2,5-dichlorophenyl)methyl]-2-oxoindol-3-ylidene]amino] acetate|LDN57444|5-Chloro-1-[(2,5-dichlorophenyl)methyl]

规格或纯度：≥98% (HPLC)

英文名称：LDN-57444

生化机理：UCH-L1 Inhibitor is an isatin O-acyl oxime compound reported to act as a potent, reversible, competitive, and active site-directed inhibitor of UCH-L1 with greater selectivity over UCH-L3. Additionally, UCH-L1 Inhibitor has been shown to increase proliferation of UCH-L1 expressing tumor cell line SH-SY5Y. Potentially useful for studying the roles of UCH-L1 in cancer, Parkinson’s disease, and other neurological disorders. Permeability may vary from cell type to cell type.Reversible, competitive ubiquitin C-terminal hydrolase-L1 (UCH-L1) inhibitor (K i = 0.4 μM. Increases ubiquitinated protein levels and decreases proteasome activity. Also induces apoptosis.

储存温度：2-8°C储存

运输条件：冰袋运输

备注：如果有可能，您尽量在使用的当天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，它们最多可以使用一个月。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。

产品介绍：LDN-57444是一种可逆的竞争性的蛋白酶体抑制剂，，抑制UCch-L1时，IC50为0.88 μM，比作用于亚型Uch-L3选择性高30倍。A potent, reversible, active site-directed UCH-L1 inhibitorLDN-57444 is a reversible, competitive proteasome inhibitor for Uch-L1 with IC50 of 0.88 μM, 28-fold selectivity over isoform Uch-L3.A potent, reversible, active site-directed UCH-L1 inhibitor

IUPAC Name：[(Z)-[5-chloro-1-[(2,5-dichlorophenyl)methyl]-2-oxoindol-3-ylidene]amino] acetate

INCHI：InChI=1S/C17H11Cl3N2O3/c1-9(23)25-21-16-13-7-12(19)3-5-15(13)22(17(16)24)8-10-6-11(18)2-4-14(10)20/h2-7H,8H2,1H3/b21-16-

InChi Key：OPQRFPHLZZPCCH-PGMHBOJBSA-N

Canonical SMILES：CC(=O)ON=C1C2=C(C=CC(=C2)Cl)N(C1=O)CC3=C(C=CC(=C3)Cl)Cl

Isomeric SMILES：CC(=O)O/N=C\1/C2=C(C=CC(=C2)Cl)N(C1=O)CC3=C(C=CC(=C3)Cl)Cl

WGK Germany：3

PubChem CID：16760696

溶解性：Soluble in DMSO (20 mg/ml).

象形图：

信号词：Warning

危险声明：H400 Very toxic to aquatic lifeH410 Very toxic to aquatic life with long lasting effects

预防措施声明：P273,P501,P391

产品包装