产品名称

英文名称：CI-994

同义词

Tacedinaline、112522-64-2、ci-994、4-acetamido-N-(2-aminophenyl)benzamide、Acetyldinaline、CI 994、4-acetylamino-N-(2'-aminophenyl)benzamide、CI994 (Tacedinaline)、Tacedinalina、N-acetyldinaline、Goe 5549、Goe-5549、PD-123654、PD 123654、4-(Acetylamino)-N-(2-aminopheny、乙酰地那林、PD-123654

产品性质

CAS编号：112522-64-2

分子式：C15H15N3O2

分子量：269.3

MDL号：MFCD00866266

PubChem编号：2746

别名：乙酰地那林|PD-123654

英文别名：Tacedinaline|112522-64-2|ci-994|4-acetamido-N-(2-aminophenyl)benzamide|Acetyldinaline|CI 994|4-acetylamino-N-(2'-aminophenyl)benzamide|CI994 (Tacedinaline)|Tacedinalina|N-acetyldinaline|Goe 5549|Goe-5549|PD-123654|PD 123654|4-(Acetylamino)-N-(2-aminopheny

规格或纯度：≥98%

英文名称：CI-994

生化机理：Description IC50 Value 0.57 uM (For HDAC1,MTT assay) CI-994 (N-acetyldinaline) is a novel oral compound with a wide spectrum of antitumor activity in preclinical models, in vitro and in vivo. The mechanism of action may involve inhibition of histone deacetylation and cell cycle arrest[1]. in vitro Different CI-994 concentrations were tested, ranging from 0.01 to 160 microM at 24, 48, and 72 h of treatment inA-549 (adenocarcinoma) and LX-1 (squamous cell carcinoma) ,with MTT assay. A concentration-dependent cell survival inhibition was observed, with an IC50 at 80 microM. The effect of CI-994, as demonstrated by recovery experiments, was cytostatic and seemed to be superimposable in both cell lines. Cytofluorimetric analysis to assess cell cycle perturbation and apoptosis was performed after 24 h of treatment, indicating a cell block with concomitant increase at G0/G1 phase, a reduction at S phase level at 20, 40, 80, and 160 microM, and apoptosis at the higher conce.Potent, selective HDAC inhibitor (K i values are 0.41 (HDAC1), 0.75 (HDAC3), 100 (HDAC6), and 100 (HDAC8) μM respectively). Induces histone H3 hyperacetylation, cell differentiation and apoptosis.

应用：An HDAC1, HDAC3, HDAC6, and HDAC8 inhibitor

储存温度：-20°C储存

运输条件：超低温冰袋运输

备注：如果有可能，您尽量在使用的当天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，它们最多可以使用一个月。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。

产品介绍：CI-994 (Tacedinaline)是抗癌化合物，能抑制HDAC1，IC50为0.57 μM，能促使细胞周期停滞于G1期。An HDAC1, HDAC3, HDAC6, and HDAC8 inhibitorCI-994 (Tacedinaline) is an anti-cancer drug which inhibits HDAC1 with IC50 of 0.57 μM and causes G1 cell cycle arrest.An HDAC1, HDAC3, HDAC6, and HDAC8 inhibitor

ALogP：1.3

IUPAC Name：4-acetamido-N-(2-aminophenyl)benzamide

INCHI：InChI=1S/C15H15N3O2/c1-10(19)17-12-8-6-11(7-9-12)15(20)18-14-5-3-2-4-13(14)16/h2-9H,16H2,1H3,(H,17,19)(H,18,20)

InChi Key：VAZAPHZUAVEOMC-UHFFFAOYSA-N

Canonical SMILES：CC(=O)NC1=CC=C(C=C1)C(=O)NC2=CC=CC=C2N

Isomeric SMILES：CC(=O)NC1=CC=C(C=C1)C(=O)NC2=CC=CC=C2N

WGK Germany：3

RTECS：CU8702023

PubChem CID：2746

CAS Registry No.：112522-64-2

ChEMBL Ligand：CHEMBL235191

溶解性：DMSO 54 mg/mL Water <1 mg/mL Ethanol <1 mg/mL

敏感性：对热敏感

熔点：242 °C(dec.)

象形图：

信号词：Warning

危险声明：H319 Causes serious eye irritation

预防措施声明：P305+P351+P338,P280,P264+P265,P337+P317

个人防护装备：dust mask type N95 (US), Eyeshields, Gloves

产品包装