产品名称

英文名称：Nilotinib (AMN-107)

同义词

Nilotinib、641571-10-0、Tasigna、AMN107、AMN 107、AMN-107、nilotinibum、Nilotinib free base、Nilotinib (AMN-107)、NSC-747599、4-Methyl-3-((4-(3-pyridinyl)-2-pyrimidinyl)amino)-N-(5-(4-methyl-1H-imidazol-1-yl)-3-(trifluoromethyl)phenyl)benzamide、4-methyl-N-[3-(4-met、尼罗替尼、尼洛替尼

产品性质

CAS编号：641571-10-0

分子式：C28H22F3N7O

分子量：529.53

PubChem编号：644241

别名：尼罗替尼|尼洛替尼

英文别名：Nilotinib|641571-10-0|Tasigna|AMN107|AMN 107|AMN-107|nilotinibum|Nilotinib free base|Nilotinib (AMN-107)|NSC-747599|4-Methyl-3-((4-(3-pyridinyl)-2-pyrimidinyl)amino)-N-(5-(4-methyl-1H-imidazol-1-yl)-3-(trifluoromethyl)phenyl)benzamide|4-methyl-N-[3-(4-met

规格或纯度：≥99%

英文名称：Nilotinib (AMN-107)

生化机理：Nilotinib is a small molecule Bcr-Abl kinase inhibitor, rationally designed to bind and inhibit the c-Abl kinase active site with more affinity than the prototypic Bcr-Abl kinase inhibitor Imatinib (sc-202180). Nilotinib demonstrates a high affinity for the kinase (IC50 < 30nM) and shows efficacy against chronic myelogenous leukemias (CML) expressing the Bcr-Abl oncogene/fusion protein, both the wild type and CMLs presenting Imatinib resistance. .Potent and selective Bcr/Abl tyrosine kinase inhibitor (IC 50 = 15 nM). JAK2/STAT5 inhibitor. Inhibits MDM2 at the post-translational level by inducing MDM2 self-ubiquitination and degradation. Shows antiproliferative and antitumor effects in vivo .

储存温度：-20°C储存

运输条件：超低温冰袋运输

备注：如果有可能，您尽量在使用的当天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，它们最多可以使用一个月。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。

产品介绍：Nilotinib (尼洛替尼; AMN-107) 是Bcr-Abl抑制剂，IC50小于30 nM。A rationally designed c-Abl and Bcr-Abl kinase inhibitorNilotinib (AMN-107)是一种特异性BCR-ABL抑制剂，在小鼠骨髓祖细胞中IC50低于30 nM。Nilotinib (AMN-107)可通过激活AMPK来诱导自噬。Nilotinib (AMN-107) is a Bcr-Abl inhibitor with IC50 less than 30 nM.A rationally designed c-Abl and Bcr-Abl kinase inhibitor

IUPAC Name：4-methyl-N-[3-(4-methylimidazol-1-yl)-5-(trifluoromethyl)phenyl]-3-[(4-pyridin-3-ylpyrimidin-2-yl)amino]benzamide

INCHI：InChI=1S/C28H22F3N7O/c1-17-5-6-19(10-25(17)37-27-33-9-7-24(36-27)20-4-3-8-32-14-20)26(39)35-22-11-21(28(29,30)31)12-23(13-22)38-15-18(2)34-16-38/h3-16H,1-2H3,(H,35,39)(H,33,36,37)

InChi Key：HHZIURLSWUIHRB-UHFFFAOYSA-N

Canonical SMILES：CC1=C(C=C(C=C1)C(=O)NC2=CC(=CC(=C2)C(F)(F)F)N3C=C(N=C3)C)NC4=NC=CC(=N4)C5=CN=CC=C5

Isomeric SMILES：CC1=C(C=C(C=C1)C(=O)NC2=CC(=CC(=C2)C(F)(F)F)N3C=C(N=C3)C)NC4=NC=CC(=N4)C5=CN=CC=C5

PubChem CID：644241

CAS Registry No.：641571-10-0

DrugBank Ligand：DB04868

Wikipedia：Nilotinib

DiscoveRx TREEspot：Nilotinib|

ChEMBL Ligand：CHEMBL255863

RCSB PDB Ligand：NIL

PEP：nilotinib

Reactome Reaction：R-HSA-9669854, R-HSA-9669900, R-HSA-9669868, R-HSA-9674430, R-HSA-9674095

Reactome Drug：R-ALL-9669716

DrugCentral Ligand：1932

溶解性：DMSO ≥10mg/mL Water <1.2mg/mL Ethanol <1.2mg/mL

密度：1.36

折光率：1.65

熔点：230-242℃

象形图：

信号词：Danger

危险声明：H315 Causes skin irritationH319 Causes serious eye irritationH373 Causes damage to organs through prolonged or repeated exposureH413 May cause long lasting harmful effects to aquatic lifeH400 Very toxic to aquatic lifeH410 Very toxic to aquatic life with long lasting effectsH372 Causes damage to organs through prolonged or repeated exposureH360 May damage fertility or the unborn childH361 Suspected of damaging fertility or the unborn child

预防措施声明：P305+P351+P338,P273,P280,P302+P352,P321,P405,P501,P264,P260,P270,P362+P364,P391,P203,P264+P265,P318,P337+P317,P332+P317,P319

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