产品名称

英文名称：AS-604850

同义词

AS-604850、648449-76-7、5-(2,2-Difluoro-benzo[1,3]dioxol-5-ylmethylene)-thiazolidine-2,4-dione、CHEMBL2216899、AS604850、5-(2,2-difluorobenzo(1,3)dioxol-5-ylmethylene)thiazolidine-2,4-dione、(5E)-5-[(2,2-DIFLUORO-1,3-BENZODIOXOL-5-YL)METHYLIDENE]-1,3-THIAZOLIDI

产品性质

CAS编号：648449-76-7

分子式：C11H5F2NO4S

分子量：285.22

MDL号：MFCD19705528

PubChem编号：11492951

英文别名：AS-604850|648449-76-7|5-(2,2-Difluoro-benzo[1,3]dioxol-5-ylmethylene)-thiazolidine-2,4-dione|CHEMBL2216899|AS604850|5-(2,2-difluorobenzo(1,3)dioxol-5-ylmethylene)thiazolidine-2,4-dione|(5E)-5-[(2,2-DIFLUORO-1,3-BENZODIOXOL-5-YL)METHYLIDENE]-1,3-THIAZOLIDI

规格或纯度：≥98%

英文名称：AS-604850

生化机理：AS-604850 is a potent, cell permeable and ATP-competitive inhibitor of PI 3-kinase γ (PI(3)Kγ). AS-604850 also exhibits selectivity over other PI 3-kinase isoforms. AS-604850 is an inhibitor of PI 3-kinase and PI 3-kinase p55 γ, PI 3-kinase p110 α and PI 3-kinase p85 α.Selective, ATP-competitive PI3Kγ inhibitor (IC 50 values are 0.25 (PI3Kγ), >20 (PI3Kδ and PI3Kβ), and 4.5 µM (PI3Kα)). Pharmacologically active in vivo .

储存温度：2-8°C储存

运输条件：冰袋运输

备注：如果有可能，您尽量在使用的当天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，它们最多可以使用一个月。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。

产品介绍：AS-604850是一种选择性的，ATP竞争性的PI3Kγ抑制剂，IC50为250 nM，作用于PI3Kγ比作用于PI3Kδ/β选择性高80倍以上，作用于PI3Kγ比作用于PI3Kα选择性高18倍。An ATP-competitive inhibitor of PI 3-kinase γ.AS-604850 is a selective, ATP-competitive PI3Kγ inhibitor with IC50 of 250 nM, over 80-fold selectivity for PI3Kγ than PI3Kδ/β, and 18-fold more selective for PI3Kγ than PI3Kα.An ATP-competitive inhibitor of PI 3-kinase γ.

IUPAC Name：(5E)-5-[(2,2-difluoro-1,3-benzodioxol-5-yl)methylidene]-1,3-thiazolidine-2,4-dione

INCHI：InChI=1S/C11H5F2NO4S/c12-11(13)17-6-2-1-5(3-7(6)18-11)4-8-9(15)14-10(16)19-8/h1-4H,(H,14,15,16)/b8-4+

InChi Key：SRLVNYDXMUGOFI-XBXARRHUSA-N

Canonical SMILES：C1=CC2=C(C=C1C=C3C(=O)NC(=O)S3)OC(O2)(F)F

Isomeric SMILES：C1=CC2=C(C=C1/C=C/3\C(=O)NC(=O)S3)OC(O2)(F)F

WGK Germany：3

PubChem CID：11492951

CAS Registry No.：648449-76-7

ChEMBL Ligand：CHEMBL1231533

RCSB PDB Ligand：BYM

溶解性：Soluble in DMSO (>10 mg/ml), water (<2 mg/ml), acetonitrile (6 mg/ml), methanol (9 mg/ml), and 100% ethanol.

象形图：

信号词：Warning

危险声明：H317 May cause an allergic skin reaction

预防措施声明：P261,P280,P302+P352,P321,P501,P272,P333+P313,P362+P364

个人防护装备：dust mask type N95 (US), Eyeshields, Faceshields, Gloves

产品包装