产品名称

英文名称：Panobinostat (LBH589)

同义词

BCP01816、Panobinostat(LBH589)、AM808102、GTPL7489、NSC 108217、AKOS005146046、N-Hydroxy-3-[4-[2-(2-methyl-1H-indol-3-yl)ethylaminomethyl]phenyl]-2(E)-propenamide、EX-A169、NVP-LBH 589、1-Brom-4-methansulfonylbenzen、EN300-7395075、LBH-589B、NVP-LBH589、NVP-LBH-589、(E、帕比司他

产品性质

CAS编号：404950-80-7

分子式：C21H23N3O2

分子量：349.44

PubChem编号：6918837

别名：帕比司他

英文别名：BCP01816|Panobinostat(LBH589)|AM808102|GTPL7489|NSC 108217|AKOS005146046|N-Hydroxy-3-[4-[2-(2-methyl-1H-indol-3-yl)ethylaminomethyl]phenyl]-2(E)-propenamide|EX-A169|NVP-LBH 589|1-Brom-4-methansulfonylbenzen|EN300-7395075|LBH-589B|NVP-LBH589|NVP-LBH-589|(E

规格或纯度：≥98%

英文名称：Panobinostat (LBH589)

生化机理：Panobinostat (LBH589) is a HDAC (histone deactylase) inhibitor of research interest for multiple diseases such as multiple myeloma. The deacetylation of histones is associated with transcriptional silencing. Panobinostat was reported to inhibit several human multiple myeloma cell lines with and IC50 ≥ 20nM. Panobinostat was also reported to induce expression of DNA damage response genes and induce apoptosis in Ph- acute lymphoblastic leukemia cells.

应用：An HDAC inhibitor reported to inhibit human multiple myeloma cell lines.

储存温度：-20°C储存

运输条件：超低温冰袋运输

产品介绍：Panobinostat (LBH589)是一种新型的，广谱的HDAC抑制剂，IC50为5 nM。Phase 3。An HDAC inhibitor reported to inhibit human multiple myeloma cell lines.Panobinostat (LBH589) is a novel broad-spectrum HDAC inhibitor with IC50 of 5 nM. Phase 3.An HDAC inhibitor reported to inhibit human multiple myeloma cell lines.

PubChem SID：488195886

PubChem SID url：https//pubchem.ncbi.nlm.nih.gov/substance/488195886

IUPAC Name：(E)-N-hydroxy-3-[4-[[2-(2-methyl-1H-indol-3-yl)ethylamino]methyl]phenyl]prop-2-enamide

INCHI：InChI=1S/C21H23N3O2/c1-15-18(19-4-2-3-5-20(19)23-15)12-13-22-14-17-8-6-16(7-9-17)10-11-21(25)24-26/h2-11,22-23,26H,12-14H2,1H3,(H,24,25)/b11-10+

InChi Key：FPOHNWQLNRZRFC-ZHACJKMWSA-N

Canonical SMILES：CC1=C(C2=CC=CC=C2N1)CCNCC3=CC=C(C=C3)C=CC(=O)NO

Isomeric SMILES：CC1=C(C2=CC=CC=C2N1)CCNCC3=CC=C(C=C3)/C=C/C(=O)NO

PubChem CID：6918837

ChEMBL Ligand：CHEMBL483254

Wikipedia：Panobinostat

CAS Registry No.：404950-80-7

RCSB PDB Ligand：LBH

PEP：panobinostat

Reactome Reaction：R-HSA-9679787

Reactome Drug：R-ALL-9679810

DrugCentral Ligand：4682

溶解性：Soluble in DMSO (70 mg/ml), methanol, water (<1.2 mg/ml), DMF (~50 mg/ml), and ethanol (~3.3 mg/ml).

象形图：

信号词：Danger

危险声明：H315 Causes skin irritationH301 Toxic if swallowedH331 Toxic if inhaledH373 Causes damage to organs through prolonged or repeated exposureH318 Causes serious eye damageH360 May damage fertility or the unborn childH301+H331 Toxic if swallowed or if inhaled

预防措施声明：P261,P280,P302+P352,P321,P405,P501,P264,P260,P271,P270,P304+P340,P403+P233,P362+P364,P330,P203,P264+P265,P301+P316,P305+P354+P338,P318,P317,P332+P317,P316,P319

产品包装