产品名称

英文名称：Tipifarnib

同义词

Tipifarnib、192185-72-1、Zarnestra、R115777、R-115777、Tipifarnib (Zarnestra)、(R)-6-(Amino(4-chlorophenyl)(1-methyl-1H-imidazol-5-yl)methyl)-4-(3-chlorophenyl)-1-methyl-2(1H)-quinolinone、IND 58359、6-[(R)-amino(4-chlorophenyl)(1-methyl-1H-imidazol-5-yl)methyl]-、6-[(R)-氨基(4-氯苯基)(1-甲基-1H-咪唑-5-基)甲基] -4-(3-氯苯基)-1-甲基-2(1H)-喹啉酮, (R)-(+)-R 115777、替吡法尼

产品性质

CAS编号：192185-72-1

分子式：C27H22Cl2N4O

分子量：489.4

PubChem编号：159324

别名：6-[(R)-氨基(4-氯苯基)(1-甲基-1H-咪唑-5-基)甲基] -4-(3-氯苯基)-1-甲基-2(1H)-喹啉酮, (R)-(+)-R 115777|替吡法尼

英文别名：Tipifarnib|192185-72-1|Zarnestra|R115777|R-115777|Tipifarnib (Zarnestra)|(R)-6-(Amino(4-chlorophenyl)(1-methyl-1H-imidazol-5-yl)methyl)-4-(3-chlorophenyl)-1-methyl-2(1H)-quinolinone|IND 58359|6-[(R)-amino(4-chlorophenyl)(1-methyl-1H-imidazol-5-yl)methyl]-

规格或纯度：98%

英文名称：Tipifarnib

生化机理：Tipifarnib is an orally active and potent farnesyltransferase (FTase) inhibitor that exhibits potent anti-tumorigenic effects. Tipifarnib mechanism of action is not fully understand. 有效的法呢基转移酶抑制剂。抑制lamin B和K-RasB肽底物的法呢基化（IC50值分别为0.86和7.9 nM）。体内外抑制肿瘤生长。

储存温度：-20°C储存

运输条件：超低温冰袋运输

产品介绍：Pre-clinical studies show that tipifarnib has antiproliferative effects on pancreatic cancer cell lines at clinically relevant concentrations (concentration that inhibits 50% growth [IC50] from 9.5 to 500 nmol/L). It also exhibits marked growth retardation and antiangiogenic effects in a pancreatic cancer xenograft model.

IUPAC Name：6-[(R)-amino-(4-chlorophenyl)-(3-methylimidazol-4-yl)methyl]-4-(3-chlorophenyl)-1-methylquinolin-2-one

INCHI：InChI=1S/C27H22Cl2N4O/c1-32-16-31-15-25(32)27(30,18-6-9-20(28)10-7-18)19-8-11-24-23(13-19)22(14-26(34)33(24)2)17-4-3-5-21(29)12-17/h3-16H,30H2,1-2H3/t27-/m1/s1

InChi Key：PLHJCIYEEKOWNM-HHHXNRCGSA-N

Canonical SMILES：CN1C=NC=C1C(C2=CC=C(C=C2)Cl)(C3=CC4=C(C=C3)N(C(=O)C=C4C5=CC(=CC=C5)Cl)C)N

Isomeric SMILES：CN1C=NC=C1[C@@](C2=CC=C(C=C2)Cl)(C3=CC4=C(C=C3)N(C(=O)C=C4C5=CC(=CC=C5)Cl)C)N

PubChem CID：159324

CAS Registry No.：192185-72-1

ChEMBL Ligand：CHEMBL289228

Wikipedia：Tipifarnib

RCSB PDB Ligand：JAN

Reactome Reaction：R-HSA-9647987

Reactome Drug：R-ALL-9647938

溶解性：溶于DMSO, 最高浓度 (mg/mL) 48.94, 最高浓度(mM) 100；溶于ethanol, 最高浓度 (mg/mL) 9.79, 最高浓度(mM) 20

象形图：

信号词：Warning

危险声明：H315 Causes skin irritationH319 Causes serious eye irritationH335 May cause respiratory irritationH302 Harmful if swallowed

预防措施声明：P261,P305+P351+P338,P280,P302+P352,P321,P405,P501,P264,P271,P270,P304+P340,P403+P233,P362+P364,P330,P264+P265,P301+P317,P337+P317,P332+P317,P319

产品包装