产品名称

英文名称：Fasudil Hydrochloride

同义词

Fasudil hydrochloride、105628-07-7、Fasudil HCl、Eril、Fasudil (HA-1077) HCl、5-((1,4-Diazepan-1-yl)sulfonyl)isoquinoline hydrochloride、Fasudil (Hydrochloride)、AT-877、Fasudil Monohydrochloride、ha-1077、SQ04N8S7BR、Fasudil, Monohydrochloride Salt、DTXSID1045615、MF、盐酸法舒地尔、5-(1-高哌嗪)磺酰基异喹啉盐酸盐、(5-异喹啉磺酰基)高哌嗪盐酸盐

产品性质

CAS编号：105628-07-7

分子式：C14H17N3O2S·HCl

分子量：327.83

MDL号：MFCD00943198

PubChem编号：163751

别名：盐酸法舒地尔|5-(1-高哌嗪)磺酰基异喹啉盐酸盐|(5-异喹啉磺酰基)高哌嗪盐酸盐

英文别名：Fasudil hydrochloride|105628-07-7|Fasudil HCl|Eril|Fasudil (HA-1077) HCl|5-((1,4-Diazepan-1-yl)sulfonyl)isoquinoline hydrochloride|Fasudil (Hydrochloride)|AT-877|Fasudil Monohydrochloride|ha-1077|SQ04N8S7BR|Fasudil, Monohydrochloride Salt|DTXSID1045615|MF

规格或纯度：98%

英文名称：Fasudil Hydrochloride

生化机理：环状核苷酸依赖性蛋白激酶抑制剂和Rho相关激酶抑制剂（IC50 =10.7μM）。在体内抑制MMP-2表达并诱导胶质母细胞瘤细胞凋亡。Ca2 +拮抗剂和血管扩张剂。还抑制血管平滑肌细胞的增殖。

应用：A selective ROCK inhibitor

储存温度：避光,-20°C储存

运输条件：超低温冰袋运输

产品介绍：Fasudil, Monohydrochloride Salt is a cell-permeable, selective ROCK inhibitor which induces neuroprotection in vitro. Studies sμggest that when acting as a ROCK inhibitor, Fasudil reduces neutrophil transendothelial migration by diminishing cytoskeletal rearrangement of endothelial cells. In addition, Fasudil significantly protects against MeHg-induced axonal degeneration and apoptotic cell death in cultured cortical neurons. Alternate studies show that Fasudil plays an important role in osteoblastic differentiation of stromal cells via increasing the mRNA expression of collagen-I, osteocalcin, and bone morphogenetic protein-2 (BMP-2). Furthermore, noggin, a BMP-2 antagonist can reverse the effects of Fasudil induced mRNA expression of collagen-I and osteocalcin. Upon inhibition of Rho-kinase, Fasudil significantly stimulates FGF-2-induced accumulation of vascular endothelial growth factor (VEGF). Fasudil, Monohydrochloride Salt is an inhibitor of cGKI, MSK1, PKA, PRK2, Rock-2, AMPK, CaMKII, Polycystin-1 and Rsk-1.A selective ROCK inhibitorFasudil, Monohydrochloride Salt is a cell-permeable, selective ROCK inhibitor which induces neuroprotection in vitro. Studies suggest that when acting as a ROCK inhibitor, Fasudil reduces neutrophil transendothelial migration by diminishing cytoskeletal rearrangement of endothelial cells. In addition, Fasudil significantly protects against MeHg-induced axonal degeneration and apoptotic cell death in cultured cortical neurons. Alternate studies show that Fasudil plays an important role in osteoblastic differentiation of stromal cells via increasing the mRNA expression of collagen-I, osteocalcin, and bone morphogenetic protein-2 (BMP-2). Furthermore, noggin, a BMP-2 antagonist can reverse the effects of Fasudil induced mRNA expression of collagen-I and osteocalcin. Upon inhibition of Rho-kinase, Fasudil significantly stimulates FGF-2-induced accumulation of vascular endothelial growth factor (VEGF). Fasudil, Monohydrochloride Salt is an inhibitor of cGKI, MSK1, PKA, PRK2, Rock-2, AMPK, CaMKII, Polycystin-1 and Rsk-1.A selective ROCK inhibitor

IUPAC Name：5-(1,4-diazepan-1-ylsulfonyl)isoquinoline;hydrochloride

INCHI：InChI=1S/C14H17N3O2S.ClH/c18-20(19,17-9-2-6-15-8-10-17)14-4-1-3-12-11-16-7-5-13(12)14;/h1,3-5,7,11,15H,2,6,8-10H2;1H

InChi Key：LFVPBERIVUNMGV-UHFFFAOYSA-N

Canonical SMILES：C1CNCCN(C1)S(=O)(=O)C2=CC=CC3=C2C=CN=C3.Cl

Isomeric SMILES：C1CNCCN(C1)S(=O)(=O)C2=CC=CC3=C2C=CN=C3.Cl

WGK Germany：1

RTECS：HM4033500

PubChem CID：163751

Reaxy-Rn：5466340

溶解性：溶于water, 最高浓度 (mg/mL) 32.78, 最高浓度(mM) 100；溶于DMSO, 最高浓度 (mg/mL) 24.59, 最高浓度(mM) 75

敏感性：对光线敏感

折光率：1.62

沸点：506.2° C

熔点：222 °C

象形图：

信号词：Warning

危险声明：H302 Harmful if swallowed

预防措施声明：P501,P264,P270,P330,P301+P317

Merck Index：3942

产品包装