产品名称

英文名称：Fosaprepitant dimeglumine salt

同义词

Fosaprepitant dimeglumine、265121-04-8、Fosaprepitant dimeglumine salt、Ivemend、Fosaprepitant meglumine、MK-0517、Fosaprepitant (dimeglumine)、UNII-D35FM8T64X、Fosaprepitant (as dimeglumine)、D35FM8T64X、CHEBI64311、Fosaprepitant dimeglumine [USAN]、DTXSID50181095

产品性质

CAS编号：265121-04-8

分子式：C23H22F7N4O6P·2C7H17NO5

分子量：1004.83

PubChem编号：135564864

英文别名：Fosaprepitant dimeglumine|265121-04-8|Fosaprepitant dimeglumine salt|Ivemend|Fosaprepitant meglumine|MK-0517|Fosaprepitant (dimeglumine)|UNII-D35FM8T64X|Fosaprepitant (as dimeglumine)|D35FM8T64X|CHEBI64311|Fosaprepitant dimeglumine [USAN]|DTXSID50181095|

规格或纯度：≥99%

英文名称：Fosaprepitant dimeglumine salt

储存温度：-20°C储存

运输条件：超低温冰袋运输

备注：5mg、50mg、10mg卖完停产，不再备货

产品介绍：Fosaprepitant dimeglumine salt是一种水溶性的阿瑞匹坦（aprepitant）磷酰基前体药物，是一种NK1拮抗剂。Fosaprepitant is a water-soluble phosphoryl prodrug for Aprepitant which is a NK1 antagonist.

IUPAC Name：[3-[[(2R,3S)-2-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)morpholin-4-yl]methyl]-5-oxo-4H-1,2,4-triazol-1-yl]phosphonic acid;(2R,3R,4R,5S)-6-(methylamino)hexane-1,2,3,4,5-pentol

INCHI：InChI=1S/C23H22F7N4O6P.2C7H17NO5/c1-12(14-8-15(22(25,26)27)10-16(9-14)23(28,29)30)40-20-19(13-2-4-17(24)5-3-13)33(6-7-39-20)11-18-31-21(35)34(32-18)41(36,37)38;2*1-8-2-4(10)6(12)7(13)5(11)3-9/h2-5,8-10,12,19-20H,6-7,11H2,1H3,(H,31,32,35)(H2,36,37,38);2*4-13H,2-3H2,1H3/t12-,19+,20-;2*4-,5+,6+,7+/m100/s1

InChi Key：VRQHBYGYXDWZDL-OOZCZQCLSA-N

Canonical SMILES：CC(C1=CC(=CC(=C1)C(F)(F)F)C(F)(F)F)OC2C(N(CCO2)CC3=NN(C(=O)N3)P(=O)(O)O)C4=CC=C(C=C4)F.CNCC(C(C(C(CO)O)O)O)O.CNCC(C(C(C(CO)O)O)O)O

Isomeric SMILES：C[C@H](C1=CC(=CC(=C1)C(F)(F)F)C(F)(F)F)O[C@@H]2[C@@H](N(CCO2)CC3=NN(C(=O)N3)P(=O)(O)O)C4=CC=C(C=C4)F.CNC[C@@H]([C@H]([C@@H]([C@@H](CO)O)O)O)O.CNC[C@@H]([C@H]([C@@H]([C@@H](CO)O)O)O)O

关联CAS：172673-20-0

PubChem CID：135564864

溶解性：DMSO 201 mg/mL Water 135 mg/mL Ethanol

象形图：

信号词：Danger

危险声明：H315 Causes skin irritationH319 Causes serious eye irritationH373 Causes damage to organs through prolonged or repeated exposureH302 Harmful if swallowedH318 Causes serious eye damageH410 Very toxic to aquatic life with long lasting effects

预防措施声明：P305+P351+P338,P273,P280,P302+P352,P321,P501,P264,P260,P270,P362+P364,P391,P330,P264+P265,P301+P317,P305+P354+P338,P317,P337+P317,P332+P317,P319

产品包装