产品名称

英文名称：Capsaicin

同义词

CAPSAICIN (USP-RS)、6-Nonenamide, N-((4-hydroxy-3-methoxyphenyl)methyl)-8-methyl-, (E)-、N-[(4-Hydroxy-3-methoxyphenyl)methyl]-8-methyl-6-nonenamide、NCGC00017337-02、N-(4-hydroxy-3-methoxybenzyl)-8-methylnon-6-enamide、(6E)-N-{[4-hydroxy-3-(methyloxy)phenyl]m、辣椒素

产品性质

CAS编号：404-86-4

分子式：C18H27NO3

分子量：305.41

Beilstein号：2816484

EC号：206-969-8

MDL号：MFCD00017259

PubChem编号：1548943

别名：辣椒素

英文别名：CAPSAICIN (USP-RS)|6-Nonenamide, N-((4-hydroxy-3-methoxyphenyl)methyl)-8-methyl-, (E)-|N-[(4-Hydroxy-3-methoxyphenyl)methyl]-8-methyl-6-nonenamide|NCGC00017337-02|N-(4-hydroxy-3-methoxybenzyl)-8-methylnon-6-enamide|(6E)-N-{[4-hydroxy-3-(methyloxy)phenyl]m

规格或纯度：≥95%(HPLC)

英文名称：Capsaicin

生化机理：原型香草类受体激动剂（大鼠和人类VR1受体的pEC50值分别为7.97和7.10）。激发原发传入感觉神经元的子集，具有随后的抗伤害感受和消炎作用。可逆地抑制血小板聚集。

应用：A TRPV1 receptor agonist

储存温度：2-8°C储存

运输条件：冰袋运输

产品介绍：Capsaicin acts as an agonist at the VR1 (TRPV1) receptor, a ligand-gated non-selective cation channel. It exhibits neuroprotective effects in a model of transient global cerebral ischemia and induces release of substance P from afferent nociceptive specific neurons. Capsaicin also Inhibits NFκB activation by TNF and reversibly inhibits platelet aggregation. Improper activation of NF-κB has been linked to cancer, immune and inflammatory diseases, and viral infection.A TRPV1 receptor agonistCapsaicin acts as an agonist at the VR1 (TRPV1) receptor, a ligand-gated non-selective cation channel. It exhibits neuroprotective effects in a model of transient global cerebral ischemia and induces release of substance P from afferent nociceptive specific neurons. Capsaicin also Inhibits NFκB activation by TNF and reversibly inhibits platelet aggregation. Improper activation of NF-κB has been linked to cancer, immune and inflammatory diseases, and viral infection.A TRPV1 receptor agonist

ALogP：3.6

IUPAC Name：(E)-N-[(4-hydroxy-3-methoxyphenyl)methyl]-8-methylnon-6-enamide

INCHI：InChI=1S/C18H27NO3/c1-14(2)8-6-4-5-7-9-18(21)19-13-15-10-11-16(20)17(12-15)22-3/h6,8,10-12,14,20H,4-5,7,9,13H2,1-3H3,(H,19,21)/b8-6+

InChi Key：YKPUWZUDDOIDPM-SOFGYWHQSA-N

Canonical SMILES：CC(C)C=CCCCCC(=O)NCC1=CC(=C(C=C1)O)OC

Isomeric SMILES：CC(C)/C=C/CCCCC(=O)NCC1=CC(=C(C=C1)O)OC

WGK Germany：3

RTECS：RA8530000

PubChem CID：1548943

UN Number：2811

溶解性：溶于DMSO, 最高浓度 (mg/mL) 15.27, 最高浓度(mM) 50；溶于ethanol, 最高浓度 (mg/mL) 15.27, 最高浓度(mM) 50

密度：1.041

闪点(℉)：235.4 °F

闪点(℃)：113℃

熔点：65°C

象形图：

信号词：Danger

危险声明：H315 Causes skin irritationH301 Toxic if swallowedH302 Harmful if swallowedH318 Causes serious eye damage

预防措施声明：P280,P302+P352,P321,P405,P501,P264,P270,P362+P364,P330,P264+P265,P301+P316,P301+P317,P305+P354+P338,P317,P332+P317

Merck Index：1768

个人防护装备：Eyeshields,Faceshields,Gloves,type P2 (EN 143) respirator cartridges

产品包装