产品名称

英文名称：Prazosin Hydrochloride

同义词

Prazosin hydrochloride、19237-84-4、Prazosin HCl、Minipress、Vasoflex、Peripress、Furazosin hydrochloride、Minipress Xl、Deprazolin、Hypovase、Hypovasole、Sinetens、1-(4-Amino-6,7-dimethoxy-2-quinazolinyl)-4-(2-furanylcarbonyl)piperazine hydrochloride、CP-12299-1、NSC、盐酸哌唑嗪、脉哌斯、脲宁平、1-(4-氨基-6,7-二甲氧基-2-喹唑啉基)-4-(2-呋喃甲酰)哌嗪盐酸盐、1-(4-氨基-6,7-二甲氧基-2-喹唑啉基)-4-(2-呋喃甲酰基)哌嗪盐酸盐、脉宁平盐酸盐

产品性质

CAS编号：19237-84-4

分子式：C19H21N5O4·HCl

分子量：419.87

Beilstein号：4303560

MDL号：MFCD00058177

PubChem编号：68546

别名：盐酸哌唑嗪|脉哌斯|脲宁平|1-(4-氨基-6,7-二甲氧基-2-喹唑啉基)-4-(2-呋喃甲酰)哌嗪盐酸盐|1-(4-氨基-6,7-二甲氧基-2-喹唑啉基)-4-(2-呋喃甲酰基)哌嗪盐酸盐|脉宁平盐酸盐

英文别名：Prazosin hydrochloride|19237-84-4|Prazosin HCl|Minipress|Vasoflex|Peripress|Furazosin hydrochloride|Minipress Xl|Deprazolin|Hypovase|Hypovasole|Sinetens|1-(4-Amino-6,7-dimethoxy-2-quinazolinyl)-4-(2-furanylcarbonyl)piperazine hydrochloride|CP-12299-1|NSC

规格或纯度：≥98.0%

英文名称：Prazosin Hydrochloride

生化机理：Peripheral α1-adrenoceptor antagonist; vasodilator. Prazosin can be used to treat chronic posttraumatic stress disorder (PTSD). It plays a role in reducing blood pressure by relaxing blood vessels, hence used in the treatment of high blood pressure.Peripheral α 1 and α 2 adrenoceptor antagonist. Orally active vasodilator. Also melatonin MT 3 antagonist.外周 α1-肾上腺素能受体拮抗剂；血管扩张剂。哌唑嗪可用于治疗慢性创伤后应激障碍（PTSD）。它通过舒张血管起降血压作用，因此可用于治疗高血压。

应用：Prazosin hydrochloride has been used · to block the α1adrenergic receptors that mediate sympathetic vasoconstriction in mice. · as an α1-adrenoceptor blocker,administered intragastrically in rats. · as a vasodilator,administered together with inuslin into the left ventricle of mice for the assessment of its effects on renal functions.

储存温度：-20°C储存

运输条件：超低温冰袋运输

备注：如果有可能，您尽量在使用的当天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，它们最多可以使用一个月。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。

产品介绍：Prazosin hydrochloride (盐酸哌唑嗪)是α肾上腺素阻断剂，可作用于高血压、焦虑和恐慌症等哌唑嗪是一种α-肾上腺素能阻滞剂。它被视为一种周围血管舒张抗高血压药物。哌唑嗪是喹唑啉的衍生物。应用盐酸哌唑嗪已用于• 阻断介导小鼠交感血管收缩的 α1 肾上腺素能受体• 作为 α1-肾上腺素受体阻滞剂，大鼠灌胃给药• 作为血管扩张剂，与胰岛素一起注入小鼠左心室，评价其对肾功能的影响Prazosin is an alpha-adrenergic blocker and is a sympatholytic drug used to treat high blood pressure and anxiety, PTSD, and panic disorder.razosin hydrochloride has been used• to block the α1adrenergic receptors that mediate sympathetic vasoconstriction in mice.• as an α1-adrenoceptor blocker,administered intragastrically in rats.• as a vasodilator,administered together with inuslin into the left ventricle of mice for the assessment of its effects on renal functions.

IUPAC Name：[4-(4-amino-6,7-dimethoxyquinazolin-2-yl)piperazin-1-yl]-(furan-2-yl)methanone;hydrochloride

INCHI：InChI=1S/C19H21N5O4.ClH/c1-26-15-10-12-13(11-16(15)27-2)21-19(22-17(12)20)24-7-5-23(6-8-24)18(25)14-4-3-9-28-14;/h3-4,9-11H,5-8H2,1-2H3,(H2,20,21,22);1H

InChi Key：WFXFYZULCQKPIP-UHFFFAOYSA-N

Canonical SMILES：COC1=C(C=C2C(=C1)C(=NC(=N2)N3CCN(CC3)C(=O)C4=CC=CO4)N)OC.Cl

Isomeric SMILES：COC1=C(C=C2C(=C1)C(=NC(=N2)N3CCN(CC3)C(=O)C4=CC=CO4)N)OC.Cl

WGK Germany：3

RTECS：VA1350000

PubChem CID：68546

Reaxy-Rn：4303561

溶解性：H2O 0.5 mg/mL，methanol 6 mg/mL，dilute aqueous acid insoluble.

敏感性：对光敏感

熔点：285°C(lit.)

象形图：

信号词：Warning

危险声明：H315 Causes skin irritationH319 Causes serious eye irritationH335 May cause respiratory irritationH373 Causes damage to organs through prolonged or repeated exposureH302 Harmful if swallowedH361 Suspected of damaging fertility or the unborn child

预防措施声明：P261,P305+P351+P338,P280,P302+P352,P321,P405,P501,P264,P260,P271,P270,P304+P340,P403+P233,P362+P364,P330,P203,P264+P265,P301+P317,P318,P337+P317,P332+P317,P319

Merck Index：7717

个人防护装备：dust mask type N95 (US)， Eyeshields， Gloves

产品包装