产品名称

英文名称：Irinotecan HCl Trihydrate

同义词

IRINOTECAN HYDROCHLORIDE Trihydrate、136572-09-3、Camptosar、Irinotecan Hcl Trihydrate、Campto、Onivyde、CPT 11、CPT-11、Irinotecan hydrochloride hydrate、CPT-11 Trihydrate、IRINOTECAN MONOHYDROCHLORIDE TRIHYDRATE、U-101,440E、Irinotecan (hydrochloride trihydrate)、04、三水盐酸伊立替康

产品性质

CAS编号：136572-09-3

分子式：C33H38N4O6·HCl·3H2O

分子量：677.18

MDL号：MFCD01765731

PubChem编号：60837

别名：三水盐酸伊立替康

英文别名：IRINOTECAN HYDROCHLORIDE Trihydrate|136572-09-3|Camptosar|Irinotecan Hcl Trihydrate|Campto|Onivyde|CPT 11|CPT-11|Irinotecan hydrochloride hydrate|CPT-11 Trihydrate|IRINOTECAN MONOHYDROCHLORIDE TRIHYDRATE|U-101,440E|Irinotecan (hydrochloride trihydrate)|04

规格或纯度：≥98%

英文名称：Irinotecan HCl Trihydrate

生化机理：Irinotecan hydrochloride trihydrate, Irinotecan (CPT 11), a compound within the camptothecin family, is an inhibitor of Topo I (topoisomerase I) involved in cellular DNA replication and transcription. As a Topo I inhibitor, Irinotecan inhibits the religation step of the enzyme's normal action, inducing single stranded DNA breaks. These single stranded breaks are then converted to double-stranded breaks within the course of DNA replication which is reported to induce apoptosis or repair mechanisms as a result. Irinotecan is activated by esterases to produce the activated metabolite, SN 38 and has been reported to be associated with cleavage of poly (ADP-ribose) polymerase (PARP) in colon carcinoma cells. Irinotecan's active metabolite SN 38 is additionally noted to activate p53 in the Huh7 cell line.

储存温度：2-8°C储存

运输条件：冰袋运输

产品介绍：Irinotecan HCl Trihydrate通过抑制Topoisomerase 1（拓扑异构酶1）而防止DNA解链。An inhibitor of Topo I.Irinotecan prevents DNA from unwinding by inhibition of topoisomerase 1.An inhibitor of Topo I.

IUPAC Name：[(19S)-10,19-diethyl-19-hydroxy-14,18-dioxo-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2,4(9),5,7,10,15(20)-heptaen-7-yl] 4-piperidin-1-ylpiperidine-1-carboxylate;trihydrate;hydrochloride

INCHI：InChI=1S/C33H38N4O6.ClH.3H2O/c1-3-22-23-16-21(43-32(40)36-14-10-20(11-15-36)35-12-6-5-7-13-35)8-9-27(23)34-29-24(22)18-37-28(29)17-26-25(30(37)38)19-42-31(39)33(26,41)4-2;;;;/h8-9,16-17,20,41H,3-7,10-15,18-19H2,1-2H3;1H;3*1H2/t33-;;;;/m0..../s1

InChi Key：KLEAIHJJLUAXIQ-JDRGBKBRSA-N

Canonical SMILES：CCC1=C2CN3C(=CC4=C(C3=O)COC(=O)C4(CC)O)C2=NC5=C1C=C(C=C5)OC(=O)N6CCC(CC6)N7CCCCC7.O.O.O.Cl

Isomeric SMILES：CCC1=C2CN3C(=CC4=C(C3=O)COC(=O)[C@@]4(CC)O)C2=NC5=C1C=C(C=C5)OC(=O)N6CCC(CC6)N7CCCCC7.O.O.O.Cl

RTECS：DW1060750

PubChem CID：60837

Reaxy-Rn：4838283

溶解性：DMSO 135 mg/mL Water 2 mg/mL Ethanol 7 mg/mL

敏感性：对热敏感

比旋光度：24° (C=1,MeOH)

沸点：257°C

象形图：

信号词：Danger

危险声明：H341 Suspected of causing genetic defectsH302 Harmful if swallowedH360 May damage fertility or the unborn child

预防措施声明：P280,P405,P501,P264,P281,P270,P330,P203,P301+P317,P318

Merck Index：5091

产品包装