产品名称

英文名称：Thymidine

同义词

thymidine、50-89-5、deoxythymidine、2'-Deoxythymidine、Thymidin、5-Methyldeoxyuridine、Beta-Thymidine、DThyd、5-Methyl-2'-deoxyuridine、Thymine-2-desoxyriboside、5-Methyldeoxyurindine、Deoxyribothymidine、Thymine-2-deoxyriboside、Thyminedeoxyriboside、Thymine deoxyribo、β-胸腺嘧啶核苷、胸苷、1-(2-脱氧-β-D-呋喃核糖)-5-甲基尿嘧啶、1-(2-脱氧-β-D-呋喃核糖)胸苷、2'-脱氧胸苷、胸腺嘧啶核苷

产品性质

CAS编号：50-89-5

分子式：C10H14N2O5

分子量：242.23

Beilstein号：89285

EC号：200-070-4

MDL号：MFCD00006537

PubChem编号：5789

别名：β-胸腺嘧啶核苷|胸苷|1-(2-脱氧-β-D-呋喃核糖)-5-甲基尿嘧啶|1-(2-脱氧-β-D-呋喃核糖)胸苷|2'-脱氧胸苷|胸腺嘧啶核苷

英文别名：thymidine|50-89-5|deoxythymidine|2'-Deoxythymidine|Thymidin|5-Methyldeoxyuridine|Beta-Thymidine|DThyd|5-Methyl-2'-deoxyuridine|Thymine-2-desoxyriboside|5-Methyldeoxyurindine|Deoxyribothymidine|Thymine-2-deoxyriboside|Thyminedeoxyriboside|Thymine deoxyribo

规格或纯度：99%

英文名称：Thymidine

生化机理：嘧啶脱氧核苷。强大的胸苷激酶底物（IC 50 = 16 nM）。与双链DNA中的脱氧腺苷配对。在体内同步S期的细胞。

储存温度：2-8°C储存,充氩

运输条件：冰袋运输

备注：如果有可能，您尽量在使用的当天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，它们最多可以使用一个月。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。

产品介绍：易溶于水、甲醇、热乙醇、热丙醇、热丙酮、热乙酸乙酯、吡啶、冰醋酸中，少量溶于热的氯仿中。水中溶解度46 g/L (20°C)。 Thymidine is also referred to as pyrimidine deoxynucleoside. Deoxythymidine is a nucleoside present in DNA. In a DNA double stranded structure, thymidine pairs with deoxyadeninosine. It is useful in cell synchronization during S-phase. In the salvage pathway of pyrimidines, pyrimidine phosphorylase reversibly converts thymine to thymidine.主要用于抗艾滋病药物（如齐多呋啶、石达呋啶）的制备 Thymidine (dT) is a pyrimidine deoxyriboside (deoxynucleoside) that upon sequential phosphorylation to deoxythymidine triphospate (dTTP) is used to synthesize DNA and the T-loop of transfer RNA. Thymidine is as substrate of Thymidine kinase EC 2.7.1.21 which phosphorylates the nucleoside with a phosphate derived from ATP. dT may be used to study the distribution, specificity and kinetics of a family of thymidine kinase(s). Thymidine has been used · as a supplement in HL5-modified medium for cell culture · to incubate cells in cell-cycle analysis · in cell synchronizationThymidine is also referred to as pyrimidine deoxynucleoside. Deoxythymidine is a nucleoside present in DNA. In a DNA double stranded structure, thymidine pairs with deoxyadeninosine. It is useful in cell synchronization during S-phase. In the salvage pathway of pyrimidines, pyrimidine phosphorylase reversibly converts thymine to thymidine.Thymidine (dT) is a pyrimidine deoxyriboside (deoxynucleoside) that upon sequential phosphorylation to deoxythymidine triphospate (dTTP) is used to synthesize DNA and the T-loop of transfer RNA. Thymidine is as substrate of Thymidine kinase EC 2.7.1.21 which phosphorylates the nucleoside with a phosphate derived from ATP. dT may be used to study the distribution, specificity and kinetics of a family of thymidine kinase(s).

PubChem SID：488179935

IUPAC Name：1-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-methylpyrimidine-2,4-dione

INCHI：InChI=1S/C10H14N2O5/c1-5-3-12(10(16)11-9(5)15)8-2-6(14)7(4-13)17-8/h3,6-8,13-14H,2,4H2,1H3,(H,11,15,16)/t6-,7+,8+/m0/s1

InChi Key：IQFYYKKMVGJFEH-XLPZGREQSA-N

Canonical SMILES：CC1=CN(C(=O)NC1=O)C2CC(C(O2)CO)O

Isomeric SMILES：CC1=CN(C(=O)NC1=O)[C@H]2C[C@@H]([C@H](O2)CO)O

WGK Germany：3

RTECS：XP2071000

PubChem CID：5789

Reaxy-Rn：89285

Wikipedia：Thymidine

CAS Registry No.：50-89-5

ChEBI：CHEBI17748

ChEMBL Ligand：CHEMBL52609

RCSB PDB Ligand：THM

溶解性：Soluble in water, methanol, hot ethanol, hot acetone, hot ethyl acetate, pyridine, glacial acetic acid and hydrochloric acid. Slightly soluble in hot chloroform .

密度：1.452

敏感性：对光敏感;易吸潮

比旋光度：33 ° (C=1, 1mol/L NaOH)

熔点：183-191°C

象形图：

信号词：Danger

危险声明：H335 May cause respiratory irritationH341 Suspected of causing genetic defectsH302 Harmful if swallowedH340 May cause genetic defects

预防措施声明：P261,P405,P501,P264,P281,P271,P270,P304+P340,P403+P233,P330,P203,P301+P317,P318,P319

Merck Index：9397

个人防护装备：Eyeshields,Gloves,type N95 (US),type P1 (EN143) respirator filter

产品包装