产品名称

英文名称：Raltegravir (MK-0518)

同义词

GTPL11571、SCHEMBL996804、3-oxo-estra-4,9,11-triene-17b-ol、CS-0144768、FT-0649660、hydropyrimidine-4-carboxamide、4-chloro-7-nitro-2,1,3-benzooxadiazole、Raltegravir- Bio-X、HYDROXYZINE PAMOATE [VANDF]、J05AX08、NCGC00274066-05、AKOS015902444、N-(2-(4-(4-FLUOROBENZY、雷特格韦

产品性质

CAS编号：518048-05-0

分子式：C20H21FN6O5

分子量：444.42

PubChem编号：54671008

别名：雷特格韦

英文别名：GTPL11571|SCHEMBL996804|3-oxo-estra-4,9,11-triene-17b-ol|CS-0144768|FT-0649660|hydropyrimidine-4-carboxamide|4-chloro-7-nitro-2,1,3-benzooxadiazole|Raltegravir- Bio-X|HYDROXYZINE PAMOATE [VANDF]|J05AX08|NCGC00274066-05|AKOS015902444|N-(2-(4-(4-FLUOROBENZY

规格或纯度：≥97%

英文名称：Raltegravir (MK-0518)

生化机理：Raltegravir is a potent HIV-1 integrase inhibitor. Raltegravir sensitizes S217Q PFV IN to the same extent as the WT enzyme. Raltegravir is potently active against HIV-1 in vitro. Raltegravir is also active against HIV-2 in CEMx174 cells. Raltegravir weakly inhibits hepatic cytochrome P450 activity. Raltegravir effectively attenuates viral replication. Raltegravir efficiently inhibits SIVmac251 replication in acutely infected human lymphoid CD4+ T-cell lines MT-4 and CEMx174.Raltegravir is a potent HIV-1 integrase inhibitor. It inhibits both\xa0wild-type and S217Q PFV integrase with IC 50 of 90 nM and 40 nM in cell-free assays, respectively. It is far less potent against the S217H PFV integrase mutant (IC 50 = 900 nM).

储存温度：-20°C储存

运输条件：超低温冰袋运输

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产品介绍：Raltegravir (MK-0518)是一种有效的整合酶链转移抑制剂，作用于WT和S217Q原型泡沫病毒(PFV)整合酶，IC50分别为90 nM和40 nM。A potent integrase strand transfer inhibitor for (PFV) IN.Raltegravir (MK-0518) is a potent integrase (IN) inhibitor for WT and S217Q PFV IN with IC50 of 90 nM and 40 nM, respectively.A potent integrase strand transfer inhibitor for (PFV) IN.

IUPAC Name：N-[2-[4-[(4-fluorophenyl)methylcarbamoyl]-5-hydroxy-1-methyl-6-oxopyrimidin-2-yl]propan-2-yl]-5-methyl-1,3,4-oxadiazole-2-carboxamide

INCHI：InChI=1S/C20H21FN6O5/c1-10-25-26-17(32-10)16(30)24-20(2,3)19-23-13(14(28)18(31)27(19)4)15(29)22-9-11-5-7-12(21)8-6-11/h5-8,28H,9H2,1-4H3,(H,22,29)(H,24,30)

InChi Key：CZFFBEXEKNGXKS-UHFFFAOYSA-N

Canonical SMILES：CC1=NN=C(O1)C(=O)NC(C)(C)C2=NC(=C(C(=O)N2C)O)C(=O)NCC3=CC=C(C=C3)F

Isomeric SMILES：CC1=NN=C(O1)C(=O)NC(C)(C)C2=NC(=C(C(=O)N2C)O)C(=O)NCC3=CC=C(C=C3)F

PubChem CID：54671008

CAS Registry No.：518048-05-0

ChEMBL Ligand：CHEMBL254316

BindingDB Ligand：25351

DrugBank Ligand：DB06817

RCSB PDB Ligand：RLT

溶解性：DMSO 89 mg/mL Water Ethanol

产品包装