产品名称

英文名称：Niclosamide

同义词

niclosamide、50-65-7、5-Chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxybenzamide、Niclocide、Bayluscid、Phenasal、Cestocid、Devermin、Devermine、Helmiantin、Mansonil、Radeverm、Tredemine、Vermitid、Atenase、Fenasal、Iomesan、Iomezan、Lintex、Nasemo、Sagimid、Sulqui、Yomesan、Mato、F、2',5-二氯-4'-硝基水杨酸酰替苯胺

产品性质

CAS编号：50-65-7

分子式：C13H8Cl2N2O4

分子量：327.12

Beilstein号：2820605

EC号：200-056-8,215-811-7

MDL号：MFCD00057597

PubChem编号：4477

别名：2',5-二氯-4'-硝基水杨酸酰替苯胺

英文别名：niclosamide|50-65-7|5-Chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxybenzamide|Niclocide|Bayluscid|Phenasal|Cestocid|Devermin|Devermine|Helmiantin|Mansonil|Radeverm|Tredemine|Vermitid|Atenase|Fenasal|Iomesan|Iomezan|Lintex|Nasemo|Sagimid|Sulqui|Yomesan|Mato|F

规格或纯度：98%

英文名称：Niclosamide

生化机理：抗蠕虫药，抗癌药和质子试剂。STAT3抑制剂（IC 50 = 0.25μM）。已显示抑制许多下游信号传导途径，包括mTORC1，Wnt /β-catinin，NF-κB，Notch和ROS。

运输条件：常规运输

备注：如果有可能，您尽量在使用的当天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，它们最多可以使用一个月。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。

产品介绍：Niclosamide is an inhibitor of the Stat3 signaling pathway. Niclosamide inhibits the activation, nuclear translocation and transactivation of Stat3. Niclosamide displays selectivity for Stat3 over Stat1, Stat5, JAK1, JAK2 and Src kinases. Niclosamide inhibits the transcription of Stat3 target genes and induces cell growth inhibition, apoptosis and cell cycle arrest of cancer cells with constitutively active Stat3. Niclosamide is also a FRAP inhibitor via reversible inhibition of mTORC1 signaling and stimulates autophagy in vitro. Niclosamide displays antineoplastic effects in acute myelogenous leukemia (AML) stem cells.An inhibitor of the Stat3 signaling pathway and also a FRAP inhibitor.Niclosamide is an inhibitor of the Stat3 signaling pathway. Niclosamide inhibits the activation, nuclear translocation and transactivation of Stat3. Niclosamide displays selectivity for Stat3 over Stat1, Stat5, JAK1, JAK2 and Src kinases. Niclosamide inhibits the transcription of Stat3 target genes and induces cell growth inhibition, apoptosis and cell cycle arrest of cancer cells with constitutively active Stat3. Niclosamide is also a FRAP inhibitor via reversible inhibition of mTORC1 signaling and stimulates autophagy in vitro. Niclosamide displays antineoplastic effects in acute myelogenous leukemia (AML) stem cells.An inhibitor of the Stat3 signaling pathway and also a FRAP inhibitor.

ALogP：4

PubChem SID：488179836

PubChem SID url：https//pubchem.ncbi.nlm.nih.gov/substance/488179836

IUPAC Name：5-chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxybenzamide

INCHI：InChI=1S/C13H8Cl2N2O4/c14-7-1-4-12(18)9(5-7)13(19)16-11-3-2-8(17(20)21)6-10(11)15/h1-6,18H,(H,16,19)

InChi Key：RJMUSRYZPJIFPJ-UHFFFAOYSA-N

Canonical SMILES：C1=CC(=C(C=C1[N+](=O)[O-])Cl)NC(=O)C2=C(C=CC(=C2)Cl)O

Isomeric SMILES：C1=CC(=C(C=C1[N+](=O)[O-])Cl)NC(=O)C2=C(C=CC(=C2)Cl)O

WGK Germany：2

RTECS：VN8400000

关联CAS：50-65-7,1420-04-8,1420-04-8 (2-aminoethanol (11))

PubChem CID：4477

NSC Number：178296

UN Number：3077

MeSH Entry Terms：Bayer 2353;Bayer 73;Bayluscide;Clonitralide;Fenasal;Niclocide;Niclosamide;Niclosamide, 2-Aminoethanol (11);Phenasal;Radewerm;Tr\u00e9d\u00e9mine;Yomesan

溶解性：Soluble in ethanol (25 mM), DMSO (10 mM), chloroform (very slightly), and methanol acetone (1 1) (50 mg/ml). Insoluble in water.

密度：1.161

熔点：225-230°C

象形图：

信号词：Warning

危险声明：H319 Causes serious eye irritationH400 Very toxic to aquatic lifeH410 Very toxic to aquatic life with long lasting effects

预防措施声明：P305+P351+P338,P273,P280,P501,P391,P264+P265,P337+P317

个人防护装备：Eyeshields,Gloves,type N95 (US),type P1 (EN143) respirator filter

产品包装