产品名称

英文名称：AZD5438

同义词

602306-29-6、AZD5438、AZD-5438、AZD 5438、4-(1-isopropyl-2-methyl-1H-imidazol-5-yl)-N-(4-(methylsulfonyl)phenyl)pyrimidin-2-amine、CHEMBL488436、MMV676604、4-(2-methyl-3-propan-2-ylimidazol-4-yl)-N-(4-methylsulfonylphenyl)pyrimidin-2-amine、276Z913G29、4-(2-methyl

产品性质

CAS编号：602306-29-6

分子式：C18H21N5O2S

分子量：371.46

PubChem编号：16747683

英文别名：602306-29-6|AZD5438|AZD-5438|AZD 5438|4-(1-isopropyl-2-methyl-1H-imidazol-5-yl)-N-(4-(methylsulfonyl)phenyl)pyrimidin-2-amine|CHEMBL488436|MMV676604|4-(2-methyl-3-propan-2-ylimidazol-4-yl)-N-(4-methylsulfonylphenyl)pyrimidin-2-amine|276Z913G29|4-(2-methyl

规格或纯度：98%

英文名称：AZD5438

生化机理：AZD-5438 is a potent inhibitor of cyclin-dependent kinase (cdk) 1, 2 and 9 (IC50 values are 16, 6 and 20 nM respectively). AZD-5438 exhibits antiproliferative activity in human tumor cell lines. AZD-5438 blocks cell cycling at G2-M, S and G1 phases; reduces the proportion of actively cycling cells in vivo.Potent inhibitor of cyclin-dependent kinases (CDKs) (IC 50 values\xa0= 16, 6 and 20 nM for CDK1, CDK2, and CDK9, respectively). Inhibits cdk4 and cdk7 in the sub micromolar range. Exhibits anti-proliferative activity in human tumor cell lines.

储存温度：-20°C储存

运输条件：超低温冰袋运输

备注：有关更多信息，请参考SDS。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。

产品介绍：产品介绍AZD-5438 是有效的 CDK1, CDK2, CDK9 抑制剂，IC50 值分别为 16 nM, 6 nM, 20 nM。AZD-5438 对 GSK3β，CDK5，CDK6 的抑制作用较弱。

ALogP：2.2

IUPAC Name：4-(2-methyl-3-propan-2-ylimidazol-4-yl)-N-(4-methylsulfonylphenyl)pyrimidin-2-amine

INCHI：InChI=1S/C18H21N5O2S/c1-12(2)23-13(3)20-11-17(23)16-9-10-19-18(22-16)21-14-5-7-15(8-6-14)26(4,24)25/h5-12H,1-4H3,(H,19,21,22)

InChi Key：WJRRGYBTGDJBFX-UHFFFAOYSA-N

Canonical SMILES：CC1=NC=C(N1C(C)C)C2=NC(=NC=C2)NC3=CC=C(C=C3)S(=O)(=O)C

Isomeric SMILES：CC1=NC=C(N1C(C)C)C2=NC(=NC=C2)NC3=CC=C(C=C3)S(=O)(=O)C

RTECS：UV6261160

PubChem CID：16747683

ChEMBL Ligand：CHEMBL488436

CAS Registry No.：602306-29-6

RCSB PDB Ligand：FB8

溶解性：DMSO 74 mg/mL Water <1 mg/mL Ethanol 74 mg/mL

产品包装