产品名称

英文名称：Genistein

同义词

cid_5280961、GTPL2826、BRN 0263823、DH2M523P0H、MolMap_000022、GENISTEIN (USP-RS)、Differenol A、GENISTEIN [MI]、Genistein, analytical standard、Lopac0_000520、Oprea1_437815、5-18-04-00594 (Beilstein Handbook Reference)、Genistein (Standard)、Genisterin、KBio2_000800、K、染料木素

产品性质

CAS编号：446-72-0

分子式：C15H10O5

分子量：270.24

Beilstein号：263823

EC号：207-174-9

MDL号：MFCD00016952

PubChem编号：5280961

别名：染料木素

英文别名：cid_5280961|GTPL2826|BRN 0263823|DH2M523P0H|MolMap_000022|GENISTEIN (USP-RS)|Differenol A|GENISTEIN [MI]|Genistein, analytical standard|Lopac0_000520|Oprea1_437815|5-18-04-00594 (Beilstein Handbook Reference)|Genistein (Standard)|Genisterin|KBio2_000800|K

规格或纯度：分析标准品,≥98%

英文名称：Genistein

生化机理：DescriptionIC50 Value 37.5 uM( Topo II) [3]Genistein, a phytoestrogen found in soy products, is a highly specific inhibitor of protein tyrosine kinase (PTK) which blocks the mitogenic effect mediated by EGF on NIH-3T3 cells with IC50 of 12μM or by insulin with IC50 of 19 μM. It has been shown that genistein inhibits many type of cancers including prostate cancer (PCa) by regulating several cell signaling pathways and microRNAs (miRNAs).in vitro GEN effectively reversed estrogenicity of BPA by reversing mRNA and protein expressions of ERα, IGF-1R, pIRS-1, and pAkt induced by BPA in cellular model and also significantly decreased tumor growth and in vivo expressions of ERα, pIRS-1, and pAkt in xenografted mouse model [1]. Interestingly, genistein and its analogs induced caspase 3-activation supporting apoptotic mechanism of cell death but SPG-G supported caspase 3-independent apoptosis [2]. Of the compounds tested, only genistein selectively inhibited human topo II activity and had an IC50 value of 37.5 ?M [3]in vivo Genistein significantly decreased the blood levels of total cholesterol, triglycerides, homocysteine and visfatin compared with placebo, while blood adiponectin levels were increased [4]. Leucine and genistein significantly (p<0.05) reduced the number of fights and increased latency to fights in foot shock-induced aggression; it also decreased apomorphine (5mg/kg, i.p.) induced stereotyped behavior and apomorphine induced (10mg/kg, s.c.) locomotor activity when compared with the positive control group [5].Clinical trial Cholecalciferol and Genistein Before Surgery in Treating Patients With Early Stage Prostate Cancer. Phase 2

应用：1、具有雌性激素及抗雌激素性质 2、在体内能抑制结肠癌、乳腺癌、皮肤癌、前列腺癌等 3、对多种肿瘤细胞株有抑制作用 4、具有抗氧化作用 5、可以抑制酪氨酸蛋白激酶（PTK）的活性 6、可以抑制拓扑异购酶Ⅱ的活性 7、可以预防绝经后骨质疏松 8、具有诱发细胞程序性死亡、提高抗癌药效、抑制血管生成等作用，是一种很有潜力的癌症化学预防剂，其抗癌作用及机制具有广泛的应用前景。

储存温度：-20°C储存

运输条件：超低温冰袋运输

产品介绍：溶于乙醇和DMSO， 干冷处保存。

IUPAC Name：5,7-dihydroxy-3-(4-hydroxyphenyl)chromen-4-one

INCHI：InChI=1S/C15H10O5/c16-9-3-1-8(2-4-9)11-7-20-13-6-10(17)5-12(18)14(13)15(11)19/h1-7,16-18H

InChi Key：TZBJGXHYKVUXJN-UHFFFAOYSA-N

Canonical SMILES：C1=CC(=CC=C1C2=COC3=CC(=CC(=C3C2=O)O)O)O

Isomeric SMILES：C1=CC(=CC=C1C2=COC3=CC(=CC(=C3C2=O)O)O)O

WGK Germany：3

RTECS：NR2392000

PubChem CID：5280961

Reaxy-Rn：263823

DrugBank Ligand：DB01645

BindingDB Ligand：19459

Wikipedia：Genistein

CAS Registry No.：446-72-0

ChEMBL Ligand：CHEMBL44

BitterDB Ligand：800

NURSA Ligand：10.1621/EAZK6CL65I

RCSB PDB Ligand：GEN

密度：1.548

熔点：297-298°C

象形图：

信号词：Warning

危险声明：H315 Causes skin irritationH319 Causes serious eye irritationH335 May cause respiratory irritationH302 Harmful if swallowedH400 Very toxic to aquatic lifeH410 Very toxic to aquatic life with long lasting effects

预防措施声明：P261,P305+P351+P338,P273,P280,P302+P352,P321,P405,P501,P264,P271,P270,P304+P340,P403+P233,P362+P364,P391,P330,P264+P265,P301+P317,P337+P317,P332+P317,P319

Merck Index：4391

个人防护装备：Eyeshields,Faceshields,Gloves,type N95 (US),type P1 (EN143) respirator filter

产品包装