产品名称

英文名称：Ziprasidone

同义词

Ziprasidone、146939-27-7、Geodon、Zeldox、Zipradon、ziprasidona、ziprasidonum、UNII-6UKA5VEJ6X、6UKA5VEJ6X、CP 88059、Ziprasidone (INN)、DTXSID4023753、CHEBI10119、HSDB 7745、CP-88059、5-[2-[4-(1,2-benzothiazol-3-yl)piperazin-1-yl]ethyl]-6-chloro-1,3-dihydroindol-2-one、齐拉西酮、齐哌西酮

产品性质

CAS编号：146939-27-7

分子式：C21H21ClN4OS

分子量：412.94

MDL号：MFCD00866661

PubChem编号：60854

别名：齐拉西酮|齐哌西酮

英文别名：Ziprasidone|146939-27-7|Geodon|Zeldox|Zipradon|ziprasidona|ziprasidonum|UNII-6UKA5VEJ6X|6UKA5VEJ6X|CP 88059|Ziprasidone (INN)|DTXSID4023753|CHEBI10119|HSDB 7745|CP-88059|5-[2-[4-(1,2-benzothiazol-3-yl)piperazin-1-yl]ethyl]-6-chloro-1,3-dihydroindol-2-one

规格或纯度：≥98.0%

英文名称：Ziprasidone

生化机理：Ziprasidone is a combined 5-HT (serotonin) and dopamine receptor antagonist which exhibits potent effects in preclinical assays predictive of antipsychotic activity. Whereas Ziprasidone is a dopamine antagonist in vitro and in vivo, its most potent action is antagonism of 5-HT2A receptors, where its affinity is an order of magnitude greater than that observed for dopamine D2 sites. Additionally, Ziprasidone inhibits neuronal uptake of 5-HT and norepinephrine comparable to the antidepressant imipramine. Ziprasidone differs from other atypical antipsychotic drμgs in several clinically important ways, althoμgh further experience is necessary to clarify the significance of these differences.

储存温度：-20°C储存

运输条件：超低温冰袋运输

产品介绍：Ziprasidone(CP88059)是5-HT和多巴胺受体拮抗剂，具有抗精神病活性。Ziprasidone(CP88059) is a combined 5-HT (serotonin) and dopamine receptor antagonist which exhibits potent effects of antipsychotic activity.

IUPAC Name：5-[2-[4-(1,2-benzothiazol-3-yl)piperazin-1-yl]ethyl]-6-chloro-1,3-dihydroindol-2-one

INCHI：InChI=1S/C21H21ClN4OS/c22-17-13-18-15(12-20(27)23-18)11-14(17)5-6-25-7-9-26(10-8-25)21-16-3-1-2-4-19(16)28-24-21/h1-4,11,13H,5-10,12H2,(H,23,27)

InChi Key：MVWVFYHBGMAFLY-UHFFFAOYSA-N

Canonical SMILES：C1CN(CCN1CCC2=C(C=C3C(=C2)CC(=O)N3)Cl)C4=NSC5=CC=CC=C54

Isomeric SMILES：C1CN(CCN1CCC2=C(C=C3C(=C2)CC(=O)N3)Cl)C4=NSC5=CC=CC=C54

RTECS：NM3241000

PubChem CID：60854

Reaxy-Rn：6669199

DrugBank Ligand：DB00246

CAS Registry No.：146939-27-7

ChEBI：CHEBI10119

Wikipedia：Ziprasidone

ChEMBL Ligand：CHEMBL708

BindingDB Ligand：50048803

PEP：ziprasidone

DrugCentral Ligand：2865

GPCRdb Ligand：ziprasidone

溶解性：DMSO

熔点：222 °C

象形图：

信号词：Warning

危险声明：H341 Suspected of causing genetic defectsH336 May cause drowsiness or dizziness

预防措施声明：P261,P405,P501,P281,P271,P304+P340,P403+P233,P203,P318,P319

Merck Index：10171

产品包装