产品名称

英文名称：Saxagliptin

同义词

Saxagliptin、Onglyza、361442-04-8、BMS-477118、Saxagliptin [INN]、BMS 477118、OPC-262、Saxagliptin anhydrous、8I7IO46IVQ、CHEMBL385517、DTXSID7048580、CHEBI71272、BMS477118、(1S,3S,5S)-2-((2S)-2-Amino-2-(3-hydroxyadamantan-1-yl)acetyl)-2-azabicyclo[3.1.0]hexane-3-car、沙克列汀、沙格列汀、(1S,3S,5S)-2-[(2S)-2-氨基-2-(3-羟基三环[3.3.1.1(3,7)]癸烷-1-基)乙酰基]-2-氮杂双环[3.1.0]己烷-3-腈

产品性质

CAS编号：361442-04-8

分子式：C18H25N3O2

分子量：315.41

PubChem编号：11243969

别名：沙克列汀|沙格列汀|(1S,3S,5S)-2-[(2S)-2-氨基-2-(3-羟基三环[3.3.1.1(3,7)]癸烷-1-基)乙酰基]-2-氮杂双环[3.1.0]己烷-3-腈|

英文别名：Saxagliptin|Onglyza|361442-04-8|BMS-477118|Saxagliptin [INN]|BMS 477118|OPC-262|Saxagliptin anhydrous|8I7IO46IVQ|CHEMBL385517|DTXSID7048580|CHEBI71272|BMS477118|(1S,3S,5S)-2-((2S)-2-Amino-2-(3-hydroxyadamantan-1-yl)acetyl)-2-azabicyclo[3.1.0]hexane-3-car

规格或纯度：98%

英文名称：Saxagliptin

生化机理：Saxagliptin is a drμg which was developed for the treatment of respiratory disorders such as asthma and Chronic Obstructive Pulmonary Disease (COPD). It is orally active and acts as a selective Phosphodiesterase-4 inhibitor.

储存温度：避光,-20°C储存,充氩

运输条件：超低温冰袋运输

产品介绍：Saxagliptin(BMS477118)是选择性可逆的DPP4抑制剂，IC50和Ki分别为26 nM和1.3 nM。Saxagliptin(BMS477118) is a selective and reversible DPP4 inhibitor with IC50 of 26 nM and Ki of 1.3 nM.

IUPAC Name：(1S,3S,5S)-2-[(2S)-2-amino-2-(3-hydroxy-1-adamantyl)acetyl]-2-azabicyclo[3.1.0]hexane-3-carbonitrile

INCHI：InChI=1S/C18H25N3O2/c19-8-13-2-12-3-14(12)21(13)16(22)15(20)17-4-10-1-11(5-17)7-18(23,6-10)9-17/h10-15,23H,1-7,9,20H2/t10?,11?,12-,13+,14+,15-,17?,18?/m1/s1

InChi Key：QGJUIPDUBHWZPV-SGTAVMJGSA-N

Canonical SMILES：C1C2CC2N(C1C#N)C(=O)C(C34CC5CC(C3)CC(C5)(C4)O)N

Isomeric SMILES：C1[C@@H]2C[C@@H]2N([C@@H]1C#N)C(=O)[C@H](C34CC5CC(C3)CC(C5)(C4)O)N

PubChem CID：11243969

ChEMBL Ligand：CHEMBL385517

DrugBank Ligand：DB06335

CAS Registry No.：361442-04-8

Wikipedia：Saxagliptin

ChEBI：CHEBI71272

PEP：saxagliptin

DrugCentral Ligand：4114

溶解性：DMSO 63 mg/mL Water 63 mg/mL Ethanol 24 mg/mL

敏感性：对光敏感

象形图：

信号词：Danger

危险声明：H317 May cause an allergic skin reactionH334 May cause allergy or asthma symptoms or breathing difficulties if inhaledH372 Causes damage to organs through prolonged or repeated exposureH361 Suspected of damaging fertility or the unborn child

预防措施声明：P261,P280,P302+P352,P321,P405,P501,P264,P260,P284,P270,P304+P340,P272,P333+P313,P362+P364,P203,P318,P319,P342+P316

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