产品名称

英文名称：Ganciclovir

同义词

ganciclovir、82410-32-0、Gancyclovir、Cytovene、Vitrasert、Zirgan、RS-21592、Ganciclovirum、2-Amino-9-(((1,3-dihydroxypropan-2-yl)oxy)methyl)-1H-purin-6(9H)-one、BW-759U、Cymevene、BW 759U、Virgan、2'-Nor-2'-deoxyguanosine、2'-NDG、BW 759、9-[(1,3-Dihydroxy-2-propoxy)met、9-[[2-羟基-1-(羟甲基)乙氧基]甲基]鸟嘌呤、更息洛韦、丙氧鸟苷

产品性质

CAS编号：82410-32-0

分子式：C9H13N5O4

分子量：255.23

MDL号：MFCD00870588

PubChem编号：135398740

别名：9-[[2-羟基-1-(羟甲基)乙氧基]甲基]鸟嘌呤|更息洛韦|丙氧鸟苷

英文别名：ganciclovir|82410-32-0|Gancyclovir|Cytovene|Vitrasert|Zirgan|RS-21592|Ganciclovirum|2-Amino-9-(((1,3-dihydroxypropan-2-yl)oxy)methyl)-1H-purin-6(9H)-one|BW-759U|Cymevene|BW 759U|Virgan|2'-Nor-2'-deoxyguanosine|2'-NDG|BW 759|9-[(1,3-Dihydroxy-2-propoxy)met

规格或纯度：≥98.0%

英文名称：Ganciclovir

生化机理：Ganciclovir is a nucleoside analog structurally related to Acyclovir that acts as a prodrμg activated by phosphorylation. Ganciclovir has been used in the study of “suicide” gene therapy in cancer research, where upon expression of a viral suicide gene encoding herpes simplex virus, thymidine kinase (TK), the non-toxic prodrμg ganciclovir, is converted to an active phosphorylated analog that can be incorporated into the DNA of replicating eukaryotic cells, causing death of the malignant dividing cell. Causes an irreversible cell cycle arrest at the G2/M checkpoint. Ganciclovir has also been used to study the loss of telomeres and to evaluate sensitivity of viruses to antiviral agents.Anti-viral compound. Inhibits viral replication by competitively inhibiting incorporation of dGTP into viral DNA. Active in vivo .

应用：A nucleoside analog structurally related to Acyclovir.

储存温度：2-8°C储存

运输条件：冰袋运输

备注：如果有可能，您尽量在使用的当天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，它们最多可以使用一个月。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。

产品介绍：Ganciclovir 是一种抗病毒药，作用于猫科动物1型疱疹病毒，IC50为5.2 μM。A nucleoside analog structurally related to Acyclovir.Ganciclovir is an antiviral drug for feline herpesvirus type-1 with IC50 of 5.2 μM.A nucleoside analog structurally related to Acyclovir.

ALogP：-2.5

IUPAC Name：2-amino-9-(1,3-dihydroxypropan-2-yloxymethyl)-1H-purin-6-one

INCHI：InChI=1S/C9H13N5O4/c10-9-12-7-6(8(17)13-9)11-3-14(7)4-18-5(1-15)2-16/h3,5,15-16H,1-2,4H2,(H3,10,12,13,17)

InChi Key：IRSCQMHQWWYFCW-UHFFFAOYSA-N

Canonical SMILES：C1=NC2=C(N1COC(CO)CO)N=C(NC2=O)N

Isomeric SMILES：C1=NC2=C(N1COC(CO)CO)N=C(NC2=O)N

WGK Germany：3

RTECS：MF8407000

PubChem CID：135398740

Reaxy-Rn：3654487

溶解性：Soluble in 0.1 M HCl (10 mg/ml), DMSO (5 mg/ml), water (2 mg/ml), hot methanol, and ethanol (<1 mg/ml).

敏感性：对热敏感

熔点：250°C(dec.)(lit.)

象形图：

信号词：Danger

危险声明：H360 May damage fertility or the unborn child

预防措施声明：P280,P405,P501,P203,P318

Merck Index：4363

个人防护装备：Eyeshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges

产品包装