产品名称

英文名称：N-Acetyl-Asp-Glu-Val-Asp p-nitroanilide

同义词

Ac-DEVD-pNA、N-乙酰基-Asp-Glu-Val-Asp p-硝基苯胺

产品性质

CAS编号：189950-66-1

分子式：C26H34N6O13

分子量：638.58

MDL号：MFCD00792707

PubChem编号：11527474

别名：Ac-DEVD-pNA|N-乙酰基-Asp-Glu-Val-Asp p-硝基苯胺

规格或纯度：≥97%(HPLC)

英文名称：N-Acetyl-Asp-Glu-Val-Asp p-nitroanilide

生化机理：Colorimetric substrate for caspase 3, a protease that is rapidly activated when cells are exposed to apoptotic conditions and that cleaves poly(ADP-ribose) polymerase.

储存温度：-20°C储存

运输条件：超低温冰袋运输

备注：25mg、100mg卖完停产，不再备货

产品介绍：NAc-Asp-Glu-Val-Asp-pNA;Ac-DEVD-pNA is a colorimetric substrate for caspase-3 (CPP32) (Km=9.7μM) and related cysteine proteases. It is also a substrate for caspase-6, caspase-7, caspase-8, and caspase-10. The sequence is based on PARP (poly(ADPribose) polymerase) cleavage site Asp216 for caspase-3. Cleavage is monitored colorimetrically at 405nm.A colorimetric substrate for caspase-3 (CPP32) and related cysteine proteasesNAc-Asp-Glu-Val-Asp-pNA;Ac-DEVD-pNA is a colorimetric substrate for caspase-3 (CPP32) (Km=9.7μM) and related cysteine proteases. It is also a substrate for caspase-6, caspase-7, caspase-8, and caspase-10. The sequence is based on PARP (poly(ADPribose) polymerase) cleavage site Asp216 for caspase-3. Cleavage is monitored colorimetrically at 405nm.A colorimetric substrate for caspase-3 (CPP32) and related cysteine proteases

IUPAC Name：(4S)-4-[[(2S)-2-acetamido-3-carboxypropanoyl]amino]-5-[[(2S)-1-[[(2S)-3-carboxy-1-(4-nitroanilino)-1-oxopropan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-5-oxopentanoic acid

INCHI：InChI=1S/C26H34N6O13/c1-12(2)22(26(43)30-18(11-21(38)39)24(41)28-14-4-6-15(7-5-14)32(44)45)31-23(40)16(8-9-19(34)35)29-25(42)17(10-20(36)37)27-13(3)33/h4-7,12,16-18,22H,8-11H2,1-3H3,(H,27,33)(H,28,41)(H,29,42)(H,30,43)(H,31,40)(H,34,35)(H,36,37)(H,38,39)/t16-,17-,18-,22-/m0/s1

InChi Key：GGXRLUDNGFFUKI-ORGXJRBJSA-N

Canonical SMILES：CC(C)C(C(=O)NC(CC(=O)O)C(=O)NC1=CC=C(C=C1)[N+](=O)[O-])NC(=O)C(CCC(=O)O)NC(=O)C(CC(=O)O)NC(=O)C

Isomeric SMILES：CC(C)[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)NC1=CC=C(C=C1)[N+](=O)[O-])NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(=O)O)NC(=O)C

PubChem CID：11527474

溶解性：Soluble in water (partly), DMSO, buffer, pH 7, and acetonitrilemethanol (11) (1 mg/ml).

产品包装