产品名称

英文名称：Captopril

同义词

captopril、62571-86-2、Capoten、L-Captopril、Captopryl、Lopirin、Cesplon、Garranil、Acepress、Captolane、Captoril、Tensoprel、Dilabar、Hypertil、Tenosbon、Alopresin、Captoprilum、Acepril、Apopril、Lopril、Acediur、Aceplus、Asisten、Farcopril、Hypopress、Isopresol、Tensiomin、Tensob、卡托普利、巯甲丙脯酸、(S)-1-(3-巯基-2-甲基-1-氧代丙基)-L-脯氨酸、S)-(-)-1-(3-巯基-2-甲基丙酰基)-L-脯氨酸

产品性质

CAS编号：62571-86-2

分子式：C9H15NO3S

分子量：217.29

Beilstein号：477887

EC号：263-607-1

MDL号：MFCD00168073

PubChem编号：44093

别名：卡托普利|巯甲丙脯酸|(S)-1-(3-巯基-2-甲基-1-氧代丙基)-L-脯氨酸|S)-(-)-1-(3-巯基-2-甲基丙酰基)-L-脯氨酸

英文别名：captopril|62571-86-2|Capoten|L-Captopril|Captopryl|Lopirin|Cesplon|Garranil|Acepress|Captolane|Captoril|Tensoprel|Dilabar|Hypertil|Tenosbon|Alopresin|Captoprilum|Acepril|Apopril|Lopril|Acediur|Aceplus|Asisten|Farcopril|Hypopress|Isopresol|Tensiomin|Tensob

规格或纯度：≥98%

英文名称：Captopril

生化机理：血管紧张素转换酶抑制剂。抑制血管紧张素 II 的形成，血管紧张素 II 是生物活性多肽，可促进血管生成并增加微血管密度。有效的ACE抑制剂（IC 50 = 21 nM）。可逆和竞争性白三烯A 4水解酶抑制剂（K i = 6μM，白三烯B4形成）。体内血管舒张和抗高血压作用。口服具有活性

应用：Captopril是一种血管紧张素转换酶（ACE）抑制剂，IC50为6 nM。

储存温度：-20°C储存,充氩

运输条件：超低温冰袋运输

备注：不稳定重新制作解决方案并立即使用。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。

产品介绍：Captopril is a reversible and competitive inhibitor of leukotriene A4 hydrolase (LTA4H; IC50 = 11μM). Captopril has been shown to be an inhibitor of angiotensin converting enzyme-1 (ACE1), but not ACE2 (IC50 = 22 nM). Captopril demonstrates noncompetitive inhibition of tyrosinase monophenolase activity and competitive inhibition of diphenolase activity. Captopril has also been shown to inhibit the formation of angiotensin II, a bioactive peptide that stimulates angiogenesis and increases microvessel density.Captopril是一种血管紧张素转换酶（ACE）抑制剂，IC50为6 nM。Captopril is a reversible and competitive inhibitor of leukotriene A4 hydrolase (LTA4H; IC50 = 11μM). Captopril has been shown to be an inhibitor of angiotensin converting enzyme-1 (ACE1), but not ACE2 (IC50 = 22 nM). Captopril demonstrates noncompetitive inhibition of tyrosinase monophenolase activity and competitive inhibition of diphenolase activity. Captopril has also been shown to inhibit the formation of angiotensin II, a bioactive peptide that stimulates angiogenesis and increases microvessel density.Captopril is an angiotensin-converting enzyme (ACE) inhibitor with IC50 of 6 nM.

ALogP：0.3

IUPAC Name：(2S)-1-[(2S)-2-methyl-3-sulfanylpropanoyl]pyrrolidine-2-carboxylic acid

INCHI：InChI=1S/C9H15NO3S/c1-6(5-14)8(11)10-4-2-3-7(10)9(12)13/h6-7,14H,2-5H2,1H3,(H,12,13)/t6-,7+/m1/s1

InChi Key：FAKRSMQSSFJEIM-RQJHMYQMSA-N

Canonical SMILES：CC(CS)C(=O)N1CCCC1C(=O)O

Isomeric SMILES：C[C@H](CS)C(=O)N1CCC[C@H]1C(=O)O

WGK Germany：3

RTECS：UY0550000

PubChem CID：44093

Reaxy-Rn：477887

CAS Registry No.：62571-86-2

DrugBank Ligand：DB01197

Wikipedia：Captopril

ChEBI：CHEBI3380

ChEMBL Ligand：CHEMBL1560

RCSB PDB Ligand：X8Z

PEP：captopril

Reactome Reaction：R-HSA-9614933

Reactome Drug：R-ALL-9614832

DrugCentral Ligand：484

溶解性：Soluble in water (160 mg/ml) at 25 °C, sesame and corn oils (100 mg/ml), ethanol (>100 mg/ml), isopropanol (>100 mg/ml), chloroform (>100 mg/ml), and dichloromethane (>100 mg/ml).

敏感性：对空气敏感

比旋光度：-127.5°

熔点：106°C

象形图：

信号词：Danger

危险声明：H318 Causes serious eye damageH317 May cause an allergic skin reactionH360 May damage fertility or the unborn childH361 Suspected of damaging fertility or the unborn child

预防措施声明：P261,P280,P302+P352,P321,P405,P501,P272,P333+P313,P362+P364,P203,P264+P265,P305+P354+P338,P318,P317

Merck Index：1774

个人防护装备：Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges

产品包装