产品名称

英文名称：Isotretinoin

同义词

4759-48-2、Isotretinoin、13-cis-Retinoic acid、Accutane、Claravis、Neovitamin A acid、13-cis-Vitamin A acid、Amnesteem、Roaccutane、Isotrex、Sotret、13-cis retinoic acid、Teriosal、isotretinoino、Isotretinoine、Isotretinoinum、Absorica、Roaccutan、ISOTRETINON、Roacutan、Isot、异维 A 酸、保肤灵、13-顺-视黄酸、3,7-二甲基-9-(2,6,6-三甲基环己烯)-2-顺,4-反,6-反,8-反式壬四烯酸

产品性质

CAS编号：4759-48-2

分子式：C20H28O2

分子量：300.44

Beilstein号：9(4)2388

EC号：225-296-0

MDL号：MFCD00079542

PubChem编号：5282379

别名：异维 A 酸|保肤灵|13-顺-视黄酸|3,7-二甲基-9-(2,6,6-三甲基环己烯)-2-顺,4-反,6-反,8-反式壬四烯酸

英文别名：4759-48-2|Isotretinoin|13-cis-Retinoic acid|Accutane|Claravis|Neovitamin A acid|13-cis-Vitamin A acid|Amnesteem|Roaccutane|Isotrex|Sotret|13-cis retinoic acid|Teriosal|isotretinoino|Isotretinoine|Isotretinoinum|Absorica|Roaccutan|ISOTRETINON|Roacutan|Isot

规格或纯度：≥98%

英文名称：Isotretinoin

生化机理：13- 顺 -维甲酸 (RA) 具有抗炎和抗肿瘤操作。RA 的操作是通过 RAR-β 介导的和 RAR-α受体。RA 可减弱细胞因子刺激的小鼠系膜细胞 iNOS 的表达和活性。它诱导线粒体膜通透性转换，观察为肿胀和膜电位降低，并通过细胞凋亡途径刺激细胞色素 c 的释放牵连机制。这些活动被 EGTA 和环孢霉素 A 逆转。RA 也部分通过增加转录增加 MMP-1 蛋白表达。

储存温度：-20°C储存,充氩

运输条件：超低温冰袋运输

产品介绍：A vitamin A analog that inhibits cell proliferation.13-cis-Retinoic acid has been used· as a component of fresh media for LA-N-5 differentiation· to treat medulloblastoma cells for cell differentiation· to treat spheroids for generating time-lapse videos· to examine its head- deforming activity under light and dark conditions in Xenopus laevisA vitamin A analog that inhibits cell proliferation.13-cis-Retinoic acid has been used· as a component of fresh media for LA-N-5 differentiation· to treat medulloblastoma cells for cell differentiation· to treat spheroids for generating time-lapse videos· to examine its head- deforming activity under light and dark conditions in Xenopus laevis

ALogP：6.3

IUPAC Name：(2Z,4E,6E,8E)-3,7-dimethyl-9-(2,6,6-trimethylcyclohexen-1-yl)nona-2,4,6,8-tetraenoic acid

INCHI：InChI=1S/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)/b9-6+,12-11+,15-8+,16-14-

InChi Key：SHGAZHPCJJPHSC-XFYACQKRSA-N

Canonical SMILES：CC1=C(C(CCC1)(C)C)C=CC(=CC=CC(=CC(=O)O)C)C

Isomeric SMILES：CC1=C(C(CCC1)(C)C)/C=C/C(=C/C=C/C(=C\C(=O)O)/C)/C

WGK Germany：3

RTECS：VH6440000

PubChem CID：5282379

Reaxy-Rn：1885770

ChEMBL Ligand：CHEMBL547

CAS Registry No.：4759-48-2

DrugBank Ligand：DB00982

Wikipedia：Isotretinoin

NURSA Ligand：10.1621/NDJZFRT4P4

PEP：isotretinoin

DrugCentral Ligand：1508

溶解性：Soluble in chloroform (50 mg/ml), DMSO (60 mg/ml at 25 °C), water (<1 mg/ml at 25 °C), ethanol (25 mg/ml), and ether (sparingly).

敏感性：对空气敏感 ;对光线敏感 ;对热敏感

熔点：175°C

象形图：

信号词：Danger

危险声明：H315 Causes skin irritationH319 Causes serious eye irritationH335 May cause respiratory irritationH400 Very toxic to aquatic lifeH410 Very toxic to aquatic life with long lasting effectsH360 May damage fertility or the unborn child

预防措施声明：P261,P305+P351+P338,P273,P280,P302+P352,P321,P405,P501,P264,P271,P304+P340,P403+P233,P362+P364,P391,P203,P264+P265,P318,P337+P317,P332+P317,P319

Merck Index：5228

个人防护装备：Eyeshields， full-face particle respirator type N100 (US)， Gloves， respirator cartridge type N100 (US)， type P1 (EN143) respirator filter， type P3 (EN 143) respirator cartridges

产品包装