产品名称

英文名称：Donepezil HCl

同义词

Donepezil hydrochloride、120011-70-3、Donepezil HCl、Aricept、BNAG、110119-84-1、2-((1-Benzylpiperidin-4-yl)methyl)-5,6-dimethoxy-2,3-dihydro-1H-inden-1-one hydrochloride、Aricept ODT、E-2020、E 2020、E 2020 (pharmaceutical)、ADLARITY、E2020、Donepezil (Hydrochloride)、盐酸多奈哌齐

产品性质

CAS编号：120011-70-3

分子式：C24H29NO3·HCl

分子量：415.96

MDL号：MFCD17215939

PubChem编号：5741

别名：盐酸多奈哌齐

英文别名：Donepezil hydrochloride|120011-70-3|Donepezil HCl|Aricept|BNAG|110119-84-1|2-((1-Benzylpiperidin-4-yl)methyl)-5,6-dimethoxy-2,3-dihydro-1H-inden-1-one hydrochloride|Aricept ODT|E-2020|E 2020|E 2020 (pharmaceutical)|ADLARITY|E2020|Donepezil (Hydrochloride)

规格或纯度：≥98%

英文名称：Donepezil HCl

生化机理：Donepezil Hydrochloride is a noncompetitive acetylcholinesterase inhibitor (IC50 = 11.6 nM. It is known that Donepezil Hydrochloride is a useful tool in the study of Alzheimer's disease. Studies indicate that Donepezil Hydrochloride protects the brain against diisopropylfluorophosphate-induced effects. Studies indicate that Donepezil Hydrochloride selectively inhibits acetylcholinesterase, whereas it has little effect on butyrylcholinesterase. Alternate studies sμggest that Donepezil Hydrochloride increases the concentration of extracellular acetylcholine.Potent, selective acetylcholinesterase inhibitor (IC 50 = 5.7 nM). Displays >1250 times selectivity for AChE over butyrylcholinesterase. Centrally active. Neuroprotective activity in vitro and in vivo .

应用：A noncompetitive acetylcholinesterase (AChE) inhibitor.

储存温度：-20°C储存

运输条件：超低温冰袋运输

备注：如果有可能，您尽量在使用的当天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，它们最多可以使用一个月。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。有毒，请参阅SDS以获取更多信息。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。

产品介绍：Donepezil HCl 是一种特异性的，有效的AChE抑制剂，作用于bAChE和hAChE，IC50分别为8.12 nM和11.6 nM。A noncompetitive acetylcholinesterase (AChE) inhibitor.Donepezil is a specific and potent AChE inhibitor for bAChE and hAChE with IC50 of 8.12 nM and 11.6 nM , respectively.A noncompetitive acetylcholinesterase (AChE) inhibitor.

IUPAC Name：2-[(1-benzylpiperidin-4-yl)methyl]-5,6-dimethoxy-2,3-dihydroinden-1-one;hydrochloride

INCHI：InChI=1S/C24H29NO3.ClH/c1-27-22-14-19-13-20(24(26)21(19)15-23(22)28-2)12-17-8-10-25(11-9-17)16-18-6-4-3-5-7-18;/h3-7,14-15,17,20H,8-13,16H2,1-2H3;1H

InChi Key：XWAIAVWHZJNZQQ-UHFFFAOYSA-N

Canonical SMILES：COC1=C(C=C2C(=C1)CC(C2=O)CC3CCN(CC3)CC4=CC=CC=C4)OC.Cl

Isomeric SMILES：COC1=C(C=C2C(=C1)CC(C2=O)CC3CCN(CC3)CC4=CC=CC=C4)OC.Cl

WGK Germany：1

RTECS：NK8927885

关联CAS：110119-84-1

PubChem CID：5741

Reaxy-Rn：7062905

溶解性：Soluble in water (100 mM), DMSO (1 mg/ml), methanol, ethanol (2 mg/ml), and DMF (slightly).

敏感性：对湿度敏感

熔点：220-222°C

象形图：

信号词：Danger

危险声明：H319 Causes serious eye irritationH301 Toxic if swallowed

预防措施声明：P305+P351+P338,P280,P321,P405,P501,P264,P270,P330,P264+P265,P301+P316,P337+P317

Merck Index：3419

产品包装