产品名称

英文名称：EX 527 (Selisistat)

同义词

49843-98-3、Selisistat、6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide、EX-527、EX 527、SEN0014196、SIRT1 Inhibitor III、Selisistat [INN]、EX527、EX 527 (Selisistat)、Selisistat (EX 527)、CHEMBL420311、CHEBI90369、rac-6-Chloro-2,3,4,9-tetrahydro-1H-carbazole-

产品性质

CAS编号：49843-98-3

分子式：C13H13ClN2O

分子量：248.71

MDL号：MFCD03009471

PubChem编号：5113032

英文别名：49843-98-3|Selisistat|6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide|EX-527|EX 527|SEN0014196|SIRT1 Inhibitor III|Selisistat [INN]|EX527|EX 527 (Selisistat)|Selisistat (EX 527)|CHEMBL420311|CHEBI90369|rac-6-Chloro-2,3,4,9-tetrahydro-1H-carbazole-

规格或纯度：≥98%

英文名称：EX 527 (Selisistat)

生化机理：EX 527 is a potent and selective inhibitor of the SIRT1 class III histone deacetylase enzyme, thoμght to block the release of deacetylated peptide and O-acetyl-ADP-ribose from the enzyme following the deacetylation process. EX 527 has been used a powerful tool for studying the relationship between SIRT1 and cell regulation. The deacetylation of cortactin, a protein responsible for rearrangements of the actin cytoskeleton, is associated with cell motility and possibly tumorigenesis, and blocking of this deacetylation by EX 527 correlated to a decrease in cell motility. Blocking of SIRT1 by EX 527 also demonstrated that deacetylation of the important tumor suppressor protein p53 is mediated by SIRT1 as well. EX 527 inhibits other sirtuin family deacetylases only at much higher concentrations (IC50 = 19.6 and 48.7 μM for SIRT2 and SIRT3, respectively).Selective, cell-permeable SIRT1 Inhibitor. (IC 50 = 98 nM, 19.6, 48.7 and > 100 µM for SIRT1, SIRT2, SIRT3, HDAC and NADase respectively). Shows no effect at other HDACs or SIRTs. Enhances p53 acetylation in response to DNA damaging agents.

储存温度：-20°C储存

运输条件：超低温冰袋运输

备注：如果有可能，您尽量在使用的当天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，它们最多可以使用一个月。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。

产品介绍：EX 527 (Selisistat)是一种有效的，选择性的SIRT1抑制剂，IC50为38 nM，比作用于SIRT2和SIRT3选择性高200倍以上。A selective inhibitor of SIRT1 over SIRT2 and SIRT3EX 527 is a potent and selective SIRT1 inhibitor with IC50 of 38 nM, exhibits >200-fold selectivity against SIRT2 and SIRT3.A selective inhibitor of SIRT1 over SIRT2 and SIRT3

IUPAC Name：6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide

INCHI：InChI=1S/C13H13ClN2O/c14-7-4-5-11-10(6-7)8-2-1-3-9(13(15)17)12(8)16-11/h4-6,9,16H,1-3H2,(H2,15,17)

InChi Key：FUZYTVDVLBBXDL-UHFFFAOYSA-N

Canonical SMILES：C1CC(C2=C(C1)C3=C(N2)C=CC(=C3)Cl)C(=O)N

Isomeric SMILES：C1CC(C2=C(C1)C3=C(N2)C=CC(=C3)Cl)C(=O)N

WGK Germany：3

PubChem CID：5113032

CAS Registry No.：49843-98-3

ChEMBL Ligand：CHEMBL420311

溶解性：Soluble in DMSO (10 mg/ml), ethanol (5 mg/ml), DMF (~20 mg/ml), and DMSOPBS (11 pH 7.2) (~0.5 mg/ml).

密度：1.39

敏感性：对热敏感

折光率：1.69

沸点：531.72°C/760mmHg

熔点：178°C

象形图：

信号词：Danger

危险声明：H319 Causes serious eye irritationH301 Toxic if swallowed

预防措施声明：P305+P351+P338,P280,P321,P405,P501,P264,P270,P330,P264+P265,P301+P316,P337+P317

产品包装