产品名称

英文名称：Adefovir Dipivoxil

同义词

9-[2-[Bis(pivaloyloxymethoxy)phosphorylmethoxy]ethyl]adenine 、 9-(2[bis(Pivaloyloxymethoxy)phosphorylmethoxy]ethyl)adenine、阿德伏韦酯 、 阿德幅韦二脂 、 9-[2-[双(新戊酰氧基甲氧基)磷酰甲氧基]乙基]腺嘌呤

产品性质

CAS编号：142340-99-6

分子式：C20H32N5O8P

分子量：501.47

MDL号：MFCD00869897

PubChem编号：60871

别名：阿德伏韦酯 | 阿德幅韦二脂 | 9-[2-[双(新戊酰氧基甲氧基)磷酰甲氧基]乙基]腺嘌呤

英文别名：9-[2-[Bis(pivaloyloxymethoxy)phosphorylmethoxy]ethyl]adenine | 9-(2[bis(Pivaloyloxymethoxy)phosphorylmethoxy]ethyl)adenine

规格或纯度：≥99%

英文名称：Adefovir Dipivoxil

生化机理：强大的，选择性的核苷酸类似物逆转录酶抑制剂。抑制病毒DNA合成（IC 50 = 0.2-2.5μM，HBV转染的人肝癌细胞系）。在体内显示抗病毒作用。

储存温度：-20°C储存

运输条件：超低温冰袋运输

备注：如果有可能，您尽量在使用的当天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，它们最多可以使用一个月。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。

产品介绍：Adefovir Dipivoxil works by blocking reverse transcriptase, an enzyme that is crucial for the hepatitis B virus (HBV) to reproduce in the body. Target NRTIs; HBV Adefovir Dipivoxil works by blocking reverse transcriptase, an enzyme that is crucial for the hepatitis B virus (HBV) to reproduce in the body. Adefovir Dipivoxil is used for treatment of hepatitis B and herpes simplex virus infection [1-3]. Adefovir Dipivoxil is approved for the treatment of chronic hepatitis B in adults with evidence of active viral replication and either evidence of persistent elevations in serum aminotransferases (primarily ALT) or histologically active disease. Adefovir Dipivoxil is a failed treatment for HIV[3, 4].产品介绍Adefovir dipivoxil 是一种腺苷类似物，是核苷逆转录酶 (nucleoside reverse transcriptase) 抑制剂 Adefovir 的口服前体。Adefovir dipivoxil 对 Lamivudine 耐药株和野生型菌株均有抑制作用。Adefovir dipivoxil 具有抗正痘病毒活性。Adefovir Dipivoxil works by blocking reverse transcriptase, an enzyme that is crucial for the hepatitis B virus (HBV) to reproduce in the body. Target NRTIs; HBV Adefovir Dipivoxil works by blocking reverse transcriptase, an enzyme that is crucial for the hepatitis B virus (HBV) to reproduce in the body. Adefovir Dipivoxil is used for treatment of hepatitis B and herpes simplex virus infection [1-3]. Adefovir Dipivoxil is approved for the treatment of chronic hepatitis B in adults with evidence of active viral replication and either evidence of persistent elevations in serum aminotransferases (primarily ALT) or histologically active disease. Adefovir Dipivoxil is a failed treatment for HIV[3, 4]. Catalyst employed in the Sharpless Asymmetric Dihyroxylation of (E,E)- or (E,Z)-1,3-dienoates.1 Also used in the preparation of ?-hydroxy-γ-lactones from ?,γ-unsaturated esters.2Product IntroductionAdefovir dipivoxil, an adenosine analogue, is an oral proagent of the nucleoside reverse transcriptase inhibitor Adefovir. Adefovir dipivoxil inhibits both the wild type and HBV Lamivudine-resistant strains. Adefovir dipivoxil shows anti-orthopoxvirus activity.

ALogP：1.8

PubChem SID：488183410

IUPAC Name：[2-(6-aminopurin-9-yl)ethoxymethyl-(2,2-dimethylpropanoyloxymethoxy)phosphoryl]oxymethyl 2,2-dimethylpropanoate

INCHI：InChI=1S/C20H32N5O8P/c1-19(2,3)17(26)30-11-32-34(28,33-12-31-18(27)20(4,5)6)13-29-8-7-25-10-24-14-15(21)22-9-23-16(14)25/h9-10H,7-8,11-13H2,1-6H3,(H2,21,22,23)

InChi Key：WOZSCQDILHKSGG-UHFFFAOYSA-N

Canonical SMILES：CC(C)(C)C(=O)OCOP(=O)(COCCN1C=NC2=C(N=CN=C21)N)OCOC(=O)C(C)(C)C

Isomeric SMILES：CC(C)(C)C(=O)OCOP(=O)(COCCN1C=NC2=C(N=CN=C21)N)OCOC(=O)C(C)(C)C

WGK Germany：3

RTECS：UA2459362

PubChem CID：60871

Reaxy-Rn：7060608

溶解性：DMSO ≥ 100 mg/mL (199.41 mM) H2O 0.67 mg/mL (1.34 mM; Need ultrasonic)

敏感性：对热敏感

熔点：101 °C

象形图：

信号词：Warning

危险声明：H302 Harmful if swallowedH312 Harmful in contact with skinH332 Harmful if inhaled

预防措施声明：P261,P280,P302+P352,P321,P501,P264,P271,P270,P304+P340,P362+P364,P330,P301+P317,P317

Merck Index：151

产品包装