产品名称

英文名称：Acivicin

同义词

acivicin、42228-92-2、Antibiotic AT 125、AT-125、Acivicine、AT 125、Acivicino、Acivicinum、NSC-163501、ACIA、NSC 163501、U 42126、U-42,126、NSC163501、(2S)-2-Amino-2-[(5S)-3-chloro-4,5-dihydro-1,2-oxazol-5-yl]acetic acid、U-42126、(alphaS,5S)-alpha-Amino-3-chloro-2-isoxa

产品性质

CAS编号：42228-92-2

分子式：C5H7ClN2O3

分子量：178.57

MDL号：MFCD00866432

PubChem编号：294641

英文别名：acivicin|42228-92-2|Antibiotic AT 125|AT-125|Acivicine|AT 125|Acivicino|Acivicinum|NSC-163501|ACIA|NSC 163501|U 42126|U-42,126|NSC163501|(2S)-2-Amino-2-[(5S)-3-chloro-4,5-dihydro-1,2-oxazol-5-yl]acetic acid|U-42126|(alphaS,5S)-alpha-Amino-3-chloro-2-isoxa

规格或纯度：97%

英文名称：Acivicin

生化机理：Acivicin is an antibiotic that inhibits g-glutamyl transpeptidase and transmembrane glutathione transport. Acivicin is a potent antitumor agent that induces apoptosis in human lymphoblastoid cells.Potent, irreversible inhibitor of γ-glutamyl transpeptidase (GGT). Anticancer and antitumor activity in vivo. Prevents melanoma metastasis in vitro .

应用：Acivicin is an antineoplastic antibiotic believed to act by interfering with glutamine metabolism which has been administered for research in a variety of solid tumors. Bone marrow depression and central neurotoxicity has been observed to suggest that it may be dose-limiting. Acivicin is an irreversible inhibitor of GGT (γ-glutamyl transpeptidase) ID50 = 0.54 mM. Additionally, it inhibits the enzymatic conversion of leukotriene C4 to leukotriene D4 and the bioactivation and release of nitric oxide from GSNO6. Also, the product displays anti tumor and anti-metastatic activity and blocks H. Pylori GGT-induced T-cell inhibition.

储存温度：-20°C储存

运输条件：超低温冰袋运输

备注：如果有可能，您尽量在使用的当天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，它们最多可以使用一个月。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。

产品介绍：An inhibitor of GGT used for solid tumor researchAcivicin is an antineoplastic antibiotic believed to act by interfering with glutamine metabolism which has been administered for research in a variety of solid tumors. Bone marrow depression and central neurotoxicity has been observed to sμggest that it may be dose-limiting. Acivicin is an irreversible inhibitor of GGT (γ-glutamyl transpeptidase) ID50 = 0.54 mM. Additionally, it inhibits the enzymatic conversion of leukotriene C4 to leukotriene D4 and the bioactivation and release of nitric oxide from GSNO6. Also, the product displays anti tumor and anti-metastatic activity and blocks H. Pylori GGT-induced T-cell inhibition.An inhibitor of GGT used for solid tumor researchAcivicin is an antineoplastic antibiotic believed to act by interfering with glutamine metabolism which has been administered for research in a variety of solid tumors. Bone marrow depression and central neurotoxicity has been observed to suggest that it may be dose-limiting. Acivicin is an irreversible inhibitor of GGT (γ-glutamyl transpeptidase) ID50 = 0.54 mM. Additionally, it inhibits the enzymatic conversion of leukotriene C4 to leukotriene D4 and the bioactivation and release of nitric oxide from GSNO6. Also, the product displays anti tumor and anti-metastatic activity and blocks H. Pylori GGT-induced T-cell inhibition.

IUPAC Name：(2S)-2-amino-2-[(5S)-3-chloro-4,5-dihydro-1,2-oxazol-5-yl]acetic acid

INCHI：InChI=1S/C5H7ClN2O3/c6-3-1-2(11-8-3)4(7)5(9)10/h2,4H,1,7H2,(H,9,10)/t2-,4-/m0/s1

InChi Key：QAWIHIJWNYOLBE-OKKQSCSOSA-N

Canonical SMILES：C1C(ON=C1Cl)C(C(=O)O)N

Isomeric SMILES：C1[C@H](ON=C1Cl)[C@@H](C(=O)O)N

WGK Germany：3

PubChem CID：294641

ChEMBL Ligand：CHEMBL1231101

CAS Registry No.：42228-92-2

RCSB PDB Ligand：AVN

溶解性：Soluble in water (18 mg/mL, max), and 1 N HCl (50 mg/mL, with heat as needed)

敏感性：对热敏感

产品包装