产品名称

英文名称：Palbociclib

同义词

Palbociclib、571190-30-2、PD-0332991、Ibrance、PD0332991、PD 0332991、UNII-G9ZF61LE7G、6-acetyl-8-cyclopentyl-5-methyl-2-((5-(piperazin-1-yl)pyridin-2-yl)amino)pyrido[2,3-d]pyrimidin-7(8H)-one、Palbociclib free base、G9ZF61LE7G、CHEBI85993、PD 332991、PD-332991、5711、PD0332991、6-乙酰基-8-环戊基-5-甲基-2-[[[5-(1-哌嗪基)-2-吡啶基]氨基]吡啶基[2,3-d]嘧啶-7(8H)-酮、PD991、PF 00080665、PF-00080665、PF00080665、爱博新、帕博昔利

产品性质

CAS编号：571190-30-2

分子式：C24H29N7O2

分子量：447.53

EC号：810-186-2

PubChem编号：5330286

别名：PD0332991|6-乙酰基-8-环戊基-5-甲基-2-[[[5-(1-哌嗪基)-2-吡啶基]氨基]吡啶基[2,3-d]嘧啶-7(8H)-酮|PD991|PF 00080665|PF-00080665|PF00080665|爱博新|帕博昔利

英文别名：Palbociclib|571190-30-2|PD-0332991|Ibrance|PD0332991|PD 0332991|UNII-G9ZF61LE7G|6-acetyl-8-cyclopentyl-5-methyl-2-((5-(piperazin-1-yl)pyridin-2-yl)amino)pyrido[2,3-d]pyrimidin-7(8H)-one|Palbociclib free base|G9ZF61LE7G|CHEBI85993|PD 332991|PD-332991|5711

规格或纯度：≥99%

英文名称：Palbociclib

生化机理：Palbociclib (PD-0332991) is an orally available pyridopyrimidine-derived cyclin-dependent kinase (CDK) inhibitor with potential antineoplastic activity. Palbociclib is a highly specific inhibitor of cyclindependent kinase 4 (Cdk4) (IC50, 0.011 μmol/L) and Cdk6 (IC50, 0.016 μmol/L), having no activity against a panel of 36 additional protein kinases.Potent, highly specific inhibitor of Cdk4 (IC 50 = 11 nM) and Cdk6 (IC 50 = 16 nM). Displays selectivity for Cdk4/6 over a panel of 36 additional protein kinases (IC 50 values are > 10\xa0μM).\xa0 Induces G 1 cell cycle arrest and senescence in retinoblas

储存温度：-20°C储存

运输条件：超低温冰袋运输

备注：如果有可能，您尽量在使用的当天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，它们最多可以使用一个月。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。

产品介绍：Palbociclib (PD-0332991) is an orally available pyridopyrimidine-derived cyclin-dependent kinase (CDK) inhibitor with potential antineoplastic activity.

ALogP：1.8

PubChem SID：488195370

PubChem SID url：https//pubchem.ncbi.nlm.nih.gov/substance/488195370

IUPAC Name：6-acetyl-8-cyclopentyl-5-methyl-2-[(5-piperazin-1-ylpyridin-2-yl)amino]pyrido[2,3-d]pyrimidin-7-one

INCHI：InChI=1S/C24H29N7O2/c1-15-19-14-27-24(28-20-8-7-18(13-26-20)30-11-9-25-10-12-30)29-22(19)31(17-5-3-4-6-17)23(33)21(15)16(2)32/h7-8,13-14,17,25H,3-6,9-12H2,1-2H3,(H,26,27,28,29)

InChi Key：AHJRHEGDXFFMBM-UHFFFAOYSA-N

Canonical SMILES：CC1=C(C(=O)N(C2=NC(=NC=C12)NC3=NC=C(C=C3)N4CCNCC4)C5CCCC5)C(=O)C

Isomeric SMILES：CC1=C(C(=O)N(C2=NC(=NC=C12)NC3=NC=C(C=C3)N4CCNCC4)C5CCCC5)C(=O)C

关联CAS：571190-30-2

PubChem CID：5330286

MeSH Entry Terms：6-acetyl-8-cyclopentyl-5-methyl-2-(5-piperazin-1-ylpyridin-2-ylamino)-8H-pyrido(2,3-d)pyrimidin-7-one;Ibrance;palbociclib;PD 0332991;PD-0332991;PD0332991

ChEMBL Ligand：CHEMBL189963

CAS Registry No.：571190-30-2

Wikipedia：Palbociclib

RCSB PDB Ligand：LQQ

PEP：palbociclib

DrugCentral Ligand：4941

溶解性：DMSO

象形图：

信号词：Danger

危险声明：H301 Toxic if swallowedH341 Suspected of causing genetic defectsH373 Causes damage to organs through prolonged or repeated exposureH411 Toxic to aquatic life with long lasting effectsH302 Harmful if swallowedH372 Causes damage to organs through prolonged or repeated exposureH360 May damage fertility or the unborn childH361 Suspected of damaging fertility or the unborn child

预防措施声明：P273,P280,P321,P405,P501,P264,P260,P281,P270,P391,P330,P203,P301+P316,P301+P317,P318,P319

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