产品名称

英文名称：Riociguat

同义词

AMY4218、HMS3413M12、Methyl 4,6-diamino-2-(1-(2-fluorobenzyl)-1H-pyrazolo(3,4-b)pyridin-3-yl)-5-pyrimidinyl(methyl)carbamate、EX-A2023、MFCD19443708、FT-0760451、AKOS015900718、Riocguat-d3、RIOCIGUAT [JAN]、CS-0237056、methyl N-[4,6-diamino-2-[1-[(2-fluorophenyl)me、利奥西呱

产品性质

CAS编号：625115-55-1

分子式：C20H19FN8O2

分子量：422.42

PubChem编号：11304743

别名：利奥西呱

英文别名：AMY4218|HMS3413M12|Methyl 4,6-diamino-2-(1-(2-fluorobenzyl)-1H-pyrazolo(3,4-b)pyridin-3-yl)-5-pyrimidinyl(methyl)carbamate|EX-A2023|MFCD19443708|FT-0760451|AKOS015900718|Riocguat-d3|RIOCIGUAT [JAN]|CS-0237056|methyl N-[4,6-diamino-2-[1-[(2-fluorophenyl)me

规格或纯度：≥99%

英文名称：Riociguat

生化机理：Riociguat (BAY 63-2521; BAY 632521) is a novel drμg that is currently in clinical development by Bayer. Riociguat (BAY 63-2521; BAY 632521) is a stimulator of soluble guanylate cyclase (sGC). At the moment Phase III clinical trials investigate the use of riociguat as a new approach to treat two forms of pulmonary hypertension (PH) chronic thromboembolic pulmonary hypertension (CTEPH) and pulmonary arterial hypertension (PAH). Riociguat constitutes the first drμg of a novel class of sGC stimulators.

储存温度：-20°C储存

运输条件：超低温冰袋运输

备注：5mg、50mg、10mg卖完停产，不再备货

产品介绍：Riociguat (BAY 63-2521)是可溶的鸟苷酸环化酶刺激剂。Riociguat (BAY 63-2521) is a stimulator of soluble guanylate cyclase (sGC). IC50 value Target sGC stimulator

ALogP：1.6

IUPAC Name：methyl N-[4,6-diamino-2-[1-[(2-fluorophenyl)methyl]pyrazolo[3,4-b]pyridin-3-yl]pyrimidin-5-yl]-N-methylcarbamate

INCHI：InChI=1S/C20H19FN8O2/c1-28(20(30)31-2)15-16(22)25-18(26-17(15)23)14-12-7-5-9-24-19(12)29(27-14)10-11-6-3-4-8-13(11)21/h3-9H,10H2,1-2H3,(H4,22,23,25,26)

InChi Key：WXXSNCNJFUAIDG-UHFFFAOYSA-N

Canonical SMILES：CN(C1=C(N=C(N=C1N)C2=NN(C3=C2C=CC=N3)CC4=CC=CC=C4F)N)C(=O)OC

Isomeric SMILES：CN(C1=C(N=C(N=C1N)C2=NN(C3=C2C=CC=N3)CC4=CC=CC=C4F)N)C(=O)OC

PubChem CID：11304743

CAS Registry No.：625115-55-1

Wikipedia：Riociguat

ChEMBL Ligand：CHEMBL2107834

ChEBI：CHEBI76018

RCSB PDB Ligand：GZO

DrugCentral Ligand：4807

溶解性：DMSO

象形图：

信号词：Warning

危险声明：H302 Harmful if swallowed

预防措施声明：P501,P264,P270,P330,P301+P317

产品包装