产品名称

英文名称：Tigecycline

同义词

Tigecycline、220620-09-7、Tygacil、WAY-GAR-936、GAR-936、TBG-MINO、GAR 936、CHEBI149836、Tigecycline hydrate、(4S,4aS,5aR,12aS)-9-(2-(tert-butylamino)acetamido)-4,7-bis(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,10,12,12a-tetrahydroxy-1,11-dioxo-2-naphthacen、9-叔丁基甘氨酰氨基米诺环素,替加环素

产品性质

CAS编号：220620-09-7

分子式：C29H39N5O8

分子量：585.65

MDL号：MFCD00935753

PubChem编号：54686904

别名：9-叔丁基甘氨酰氨基米诺环素,替加环素

英文别名：Tigecycline|220620-09-7|Tygacil|WAY-GAR-936|GAR-936|TBG-MINO|GAR 936|CHEBI149836|Tigecycline hydrate|(4S,4aS,5aR,12aS)-9-(2-(tert-butylamino)acetamido)-4,7-bis(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,10,12,12a-tetrahydroxy-1,11-dioxo-2-naphthacen

规格或纯度：≥96%

英文名称：Tigecycline

生化机理：Tigecycline is bacteriostatic and is a protein synthesis inhibitor by binding to the 30S ribosomal subunit of bacteria and thereby blocking entry of Aminoacyl-tRNA into the A site of the ribosome during prokaryotic translation.Glycylcycline antibiotic. Active against Gram-negative and Gram-positive bacteria. Active in vivo. Active against multi-drug resistant pathogens.

储存温度：-20°C储存

运输条件：超低温冰袋运输

备注：如果有可能，您尽量在使用的当天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，它们最多可以使用一个月。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。

产品介绍：Tigecycline is a broad spectrum glycylcycline antibiotic. Tigecycline is bacteriostatic. It inhibits protein synthesis throμgh the binding of the 30S ribosomal subunit of bacteria. This blocks entry of Aminoacyl-tRNA into the A site of the ribosome during translation. Tigecycline is active against resistant strains of gram-positive and gram-negative bacteria, avoiding the two most common mechanisms of resistance to the tetracycline antimicrobials tetracycline efflux pump proteins and ribosomal protection proteins.Tigecycline 是一种广谱的甘氨酰环素抗生素,对 E. coli (MG1655 菌株) 的平均抑制浓度 (MIC) 约为 125 ng/ mL。对 Acinetobacter baumannii (A. baumannii) 的 MIC50 和 MIC90 分别为 1 和 2 mg/L。Tigecycline is a broad spectrum glycylcycline antibiotic. Tigecycline is bacteriostatic. It inhibits protein synthesis through the binding of the 30S ribosomal subunit of bacteria. This blocks entry of Aminoacyl-tRNA into the A site of the ribosome during translation. Tigecycline is active against resistant strains of gram-positive and gram-negative bacteria, avoiding the two most common mechanisms of resistance to the tetracycline antimicrobials tetracycline efflux pump proteins and ribosomal protection proteins.A broad spectrum glycylcycline antibiotic

ALogP：1.1

IUPAC Name：(4S,4aS,5aR,12aR)-9-[[2-(tert-butylamino)acetyl]amino]-4,7-bis(dimethylamino)-1,10,11,12a-tetrahydroxy-3,12-dioxo-4a,5,5a,6-tetrahydro-4H-tetracene-2-carboxamide

INCHI：InChI=1S/C29H39N5O8/c1-28(2,3)31-11-17(35)32-15-10-16(33(4)5)13-8-12-9-14-21(34(6)7)24(38)20(27(30)41)26(40)29(14,42)25(39)18(12)23(37)19(13)22(15)36/h10,12,14,21,31,36-37,40,42H,8-9,11H2,1-7H3,(H2,30,41)(H,32,35)/t12-,14-,21-,29-/m0/s1

InChi Key：SOVUOXKZCCAWOJ-HJYUBDRYSA-N

Canonical SMILES：CC(C)(C)NCC(=O)NC1=CC(=C2CC3CC4C(C(=O)C(=C(C4(C(=O)C3=C(C2=C1O)O)O)O)C(=O)N)N(C)C)N(C)C

Isomeric SMILES：CC(C)(C)NCC(=O)NC1=CC(=C2C[C@H]3C[C@H]4[C@@H](C(=O)C(=C([C@]4(C(=O)C3=C(C2=C1O)O)O)O)C(=O)N)N(C)C)N(C)C

PubChem CID：54686904

CAS Registry No.：220620-09-7

BindingDB Ligand：50247905

DrugBank Ligand：DB00560

ChEMBL Ligand：CHEMBL376140

Antibiotic DB：2012

溶解性：DMSO 100 mg/mL Water 100 mg/mL Ethanol <1 mg/mL

敏感性：对热敏感

比旋光度：-199° (C=0.15,CH3OH)

熔点：185 °C(dec.)

象形图：

信号词：Danger

危险声明：H319 Causes serious eye irritationH411 Toxic to aquatic life with long lasting effectsH360 May damage fertility or the unborn child

预防措施声明：P305+P351+P338,P273,P280,P405,P501,P391,P203,P264+P265,P318,P337+P317

Merck Index：9432

产品包装