产品名称

英文名称：Anacetrapib

同义词

Anacetrapib - MK-0859、s2748、KBio3_001100、MLS006010190、A24886、BDBM50348228、STL554443、Anacetrapib (JAN/USAN)、Anacetrapib [USAN]、SCHEMBL570008、AS-19552、(4S,5R)-5-[3,5-bis(trifluoromethyl)phenyl]-3-{[4'-fluoro-5'isopropyl-2'-methoxy-4-(trifluoromethyl)bipheny、安塞曲匹

产品性质

CAS编号：875446-37-0

分子式：C30H25F10NO3

分子量：637.51

PubChem编号：11556427

别名：安塞曲匹

英文别名：Anacetrapib - MK-0859|s2748|KBio3_001100|MLS006010190|A24886|BDBM50348228|STL554443|Anacetrapib (JAN/USAN)|Anacetrapib [USAN]|SCHEMBL570008|AS-19552|(4S,5R)-5-[3,5-bis(trifluoromethyl)phenyl]-3-{[4'-fluoro-5'isopropyl-2'-methoxy-4-(trifluoromethyl)bipheny

规格或纯度：≥98%

英文名称：Anacetrapib

生化机理：Anacetrapib is a potent and selective CETP inhibitor for rhCETP and C13S CETP mutants with IC50 of 7.9 nM and 11.8 nM, respectively.

储存温度：-20°C储存

运输条件：超低温冰袋运输

产品介绍：Anacetrapib (MK-0859)是一种有效的，选择性，可逆的rhCETP和突变CETP(C13S)抑制剂，IC50分别为7.9 nM和11.8 nM，提高HDL-C，降低LDL-C，不提高醛固酮和血压。Phase 3。A potent and selective CETP inhibitor.Anacetrapib (MK0859) is a potent, selective, reversible rhCETP and mutant CETP(C13S) inhibitor with IC50 of 7.9 nM and 11.8 nM, increases HDL-C and decreases LDL-C, does not increase aldosterone or blood pressure. Phase 3.A potent and selective CETP inhibitor.

ALogP：8.8

IUPAC Name：(4S,5R)-5-[3,5-bis(trifluoromethyl)phenyl]-3-[[2-(4-fluoro-2-methoxy-5-propan-2-ylphenyl)-5-(trifluoromethyl)phenyl]methyl]-4-methyl-1,3-oxazolidin-2-one

INCHI：InChI=1S/C30H25F10NO3/c1-14(2)22-11-23(25(43-4)12-24(22)31)21-6-5-18(28(32,33)34)9-17(21)13-41-15(3)26(44-27(41)42)16-7-19(29(35,36)37)10-20(8-16)30(38,39)40/h5-12,14-15,26H,13H2,1-4H3/t15-,26-/m0/s1

InChi Key：MZZLGJHLQGUVPN-HAWMADMCSA-N

Canonical SMILES：CC1C(OC(=O)N1CC2=C(C=CC(=C2)C(F)(F)F)C3=CC(=C(C=C3OC)F)C(C)C)C4=CC(=CC(=C4)C(F)(F)F)C(F)(F)F

Isomeric SMILES：C[C@H]1[C@H](OC(=O)N1CC2=C(C=CC(=C2)C(F)(F)F)C3=CC(=C(C=C3OC)F)C(C)C)C4=CC(=CC(=C4)C(F)(F)F)C(F)(F)F

PubChem CID：11556427

ChEMBL Ligand：CHEMBL1800807

CAS Registry No.：875446-37-0

Wikipedia：Anacetrapib

溶解性：127 mg/mL in DMSO <1 mg/mL in Water 127 mg/mL in Ethanol.

产品包装